Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase von Angst, Daniela, Gessier, François, Janser, Philipp, Vulpetti, Anna, Wälchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred, Funhoff, Enrico G, Pulz, Robert, Cenni, Bruno

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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors von Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois

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Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages von Preuss, Inga, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Bassilana, Frederic, Gessier, Francois, Seuwen, Klaus, Sailer, Andreas W.

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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode von Gessier, François, Kallen, Joerg, Jacoby, Edgar, Chène, Patrick, Stachyra-Valat, Thérèse, Ruetz, Stephan, Jeay, Sébastien, Holzer, Philipp, Masuya, Keiichi, Furet, Pascal

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Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes von Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal

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Stereoselective Preparation of 3-Amino-2-fluoro Carboxylic Acid Derivatives, and Their Incorporation in Tetrahydropyrimidin-4(1H)-ones, and in Open-Chain and Cyclic β-Peptides von Yoshinari, Tomohiro, Gessier, François, Noti, Christian, Beck, Albert K., Seebach, Dieter

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A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV von Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Jörg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Garry, Beswick, Mandy, Baeschlin, Daniel K.

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RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α von Wang, Xiaoliang, Gessier, Francois, Perozzo, Remo, Stojkov, Darko, Hosseini, Aref, Amirshahrokhi, Keyvan, Kuchen, Stefan, Yousefi, Shida, Lötscher, Pius, Simon, Hans-Uwe

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EBI2 regulates intracellular signaling and migration in human astrocyte von Rutkowska, Aleksandra, Preuss, Inga, Gessier, Francois, Sailer, Andreas W., Dev, Kumlesh K.

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Oxysterols direct immune cell migration via EBI2 von Hannedouche, Sébastien, Zhang, Juan, Yi, Tangsheng, Shen, Weijun, Nguyen, Deborah, Pereira, João P., Guerini, Danilo, Baumgarten, Birgit U., Roggo, Silvio, Wen, Ben, Knochenmuss, Richard, Noël, Sophie, Gessier, Francois, Kelly, Lisa M., Vanek, Mirka, Laurent, Stephane, Preuss, Inga, Miault, Charlotte, Christen, Isabelle, Karuna, Ratna, Li, Wei, Koo, Dong-In, Suply, Thomas, Schmedt, Christian, Peters, Eric C., Falchetto, Rocco, Katopodis, Andreas, Spanka, Carsten, Roy, Marie-Odile, Detheux, Michel, Chen, Yu Alice, Schultz, Peter G., Cho, Charles Y., Seuwen, Klaus, Cyster, Jason G., Sailer, Andreas W.

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Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation von Pulz, Robert, Angst, Daniela, Dawson, Janet, Gessier, Francois, Gutmann, Sascha, Hersperger, Rene, Hinniger, Alexandra, Janser, Philipp, Koch, Guido, Revesz, Laszlo, Vulpetti, Anna, Waelchli, Rudolf, Zimmerlin, Alfred, Cenni, Bruno

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Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor von Gessier, Francois, Preuss, Inga, Yin, Hong, Rosenkilde, Mette M, Laurent, Stephane, Endres, Ralf, Chen, Yu A, Marsilje, Thomas H, Seuwen, Klaus, Nguyen, Deborah G, Sailer, Andreas W

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Carbohydrate transition state mimics: synthesis of imidazolo-Pyrrolidinoses as potential nectrisine surrogates von Tschamber, Théophile, Gessier, François, Dubost, Estelle, Newsome, Jeffery, Tarnus, Céline, Kohler, Josiane, Neuburger, Markus, Streith, Jacques

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Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019) von Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal

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(R)‑2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors von Choi, Ha-Soon, Rucker, Paul V, Wang, Zhicheng, Fan, Yi, Albaugh, Pamela, Chopiuk, Greg, Gessier, Francois, Sun, Fangxian, Adrian, Francisco, Liu, Guoxun, Hood, Tami, Li, Nanxin, Jia, Yong, Che, Jianwei, McCormack, Susan, Li, Allen, Li, Jie, Steffy, Auzon, Culazzo, AnneMarie, Tompkins, Celine, Phung, Van, Kreusch, Andreas, Lu, Min, Hu, Bin, Chaudhary, Apurva, Prashad, Mahavir, Tuntland, Tove, Liu, Bo, Harris, Jennifer, Seidel, H. Martin, Loren, Jon, Molteni, Valentina

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Abstract DDT01-01: Discovery of CGM097 as a novel Mdm2 inhibitor von Masuya, Keiichi, Furet, Pascal, Stutz, Stefan, Holzer, Philipp, Pissot-Soldmann, Carole, Buschmann, Nicole, Valat, Thérèse, Ferretti, Stéphane, Ruetz, Stephan, Rynn, Caroline, Berghausen, Joerg, Jacoby, Edgar, Lang, Marc, Gabriel, Tobias, Hofmann, Francesco, Kallen, Joerg, Jeay, Sébastien, Gessier, Francois

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Probing the Proteolytic Stability of β-Peptides Containing α-Fluoro- and α-Hydroxy-β-Amino Acids von Hook, David F, Gessier, François, Noti, Christian, Kast, Peter, Seebach, Dieter

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Oxysterols direct immune cell migration through EBI2 von Hannedouche, Sébastien, Zhang, Juan, Yi, Tangsheng, Shen, Weijun, Nguyen, Deborah, Pereira, João P., Guerini, Danilo, Baumgarten, Birgit U., Roggo, Silvio, Wen, Ben, Knochenmuss, Richard, Noël, Sophie, Gessier, Francois, Kelly, Lisa M., Vanek, Mirka, Laurent, Stephane, Preuss, Inga, Miault, Charlotte, Christen, Isabelle, Karuna, Ratna, Li, Wei, Koo, Dong-In, Suply, Thomas, Schmedt, Christian, Peters, Eric C., Falchetto, Rocco, Katopodis, Andreas, Spanka, Carsten, Roy, Marie-Odile, Detheux, Michel, Chen, Yu Alice, Schultz, Peter G., Cho, Charles Y., Seuwen, Klaus, Cyster, Jason G., Sailer, Andreas W.

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