Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions von Yu, Miao, Lou, Sha, Gonzalez-Bobes, Francisco

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One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent von Shi, Qing, Greenwood, Nathaniel S, Meehan, Mariah C, Park, Hyunsoo, Galella, Michael, Sandhu, Bhupinder, Khandelwal, Purnima, Coombs, John R, Gallagher, William P, Guerrero, Carlos A, Hynes, John, Dhar, T. G. Murali, Gonzalez Bobes, Francisco, Marcoux, David

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Development of a Mild and Efficient Process for Ir-Catalyzed N‑Alkylation of 4‑Bromopyridin-2-amine with a Primary Alcohol via Borrowing Hydrogen von Nimmagadda, Sri Krishna, Kalidindi, Srinivas, Bondigela, Siva Sankar, Korapati, Satish, Dasgupta, Debottam, Malik, Noormohamed Abdul, Rao, Prakasa, Maity, Prantik, Coombs, John R., Hay, Michael, Simmons, Eric M., Mukherjee, Sabuj, Vaidyanathan, Rajappa, Eastgate, Martin D., González-Bobes, Francisco

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Scalable Asymmetric Synthesis of the All Cis Triamino Cyclohexane Core of BMS-813160 von La Cruz, Thomas E, González-Bobes, Francisco, Eastgate, Martin D, Sfouggatakis, Chris, Zheng, Bin, Kopp, Nathaniel, Xiao, Yi, Fan, Yu, Galindo, Kay A, Pathirana, Charles, Galella, Michael A, Deerberg, Joerg

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Development of a Scalable Synthetic Route to BMS-986251, Part 2: Synthesis of the Tricyclic Core and the API von Kalidindi, Srinivas, Gangu, Aravind S, Kuppusamy, Sankar, Sathasivam, Shunmugaraj, Shekarappa, Vijaykumar, Murugan, Saravanan, Bondigela, Sivasankar, Kandasamy, Moorthy, Ghanta, Kishore, Vinodini, Arun, Shrikant, Abhishek, Ramachandran, Ravikumar, Gallagher, William P, Kopp, Nathaniel, González-Bobes, Francisco, Eastgate, Martin D, Vaidyanathan, Rajappa

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Syn-Selective Synthesis of β‑Branched α‑Amino Acids by Alkylation of Glycine-Derived Imines with Secondary Sulfonates von Lou, Sha, McKenna, Grace M, Tymonko, Steven A, Ramirez, Antonio, Benkovics, Tamas, Conlon, David A, González-Bobes, Francisco

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Scale-up of Azide Chemistry: A Case Study von González-Bobes, Francisco, Kopp, Nathaniel, Li, Li, Deerberg, Joerg, Sharma, Praveen, Leung, Simon, Davies, Merrill, Bush, Joseph, Hamm, Jason, Hrytsak, Michael

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Preparation of the HIV Attachment Inhibitor BMS-663068. Part 5. Selective C‑7 Bromination of the 6‑Azaindole Core von González-Bobes, Francisco, Hickey, Matthew R, Cohen, Benjamin, Bultman, Michael, Chen, Ke, Fanfair, Dayne, Rosso, Victor W, Strotman, Neil A, Mudryk, Boguslaw, Murugesan, Saravanababu, Schild, Richard L, Ivy, Sabrina, Eastgate, Martin D, Sweeney, Jason T, Conlon, David A

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Rhodium-Catalyzed Cyclopropanation of Alkenes with Dimethyl Diazomalonate von González-Bobes, Francisco, Fenster, Michaël D. B., Kiau, Susanne, Kolla, Laxma, Kolotuchin, Sergei, Soumeillant, Maxime

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A Radical Addition Approach to a Heptafluoroisopropyl Substituted Arene, Combined with a Highly Diastereoselective Annulation Reaction To Synthesize the Tricyclic Core of BMS-98625... von Gallagher, William P., Coombs, John R., Guerrero, Carlos A., Simmons, Eric M., González-Bobes, Francisco

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Development and Execution of an Ni(II)-Catalyzed Reductive Cross-Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate von Nimmagadda, Sri Krishna, Korapati, Satish, Dasgupta, Debottam, Malik, Noormohamed Abdul, Vinodini, Arun, Gangu, Aravind S., Kalidindi, Srinivas, Maity, Prantik, Bondigela, Siva Sankar, Venu, Alla, Gallagher, William P., Aytar, Selin, González-Bobes, Francisco, Vaidyanathan, Rajappa

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Enantioselective Synthesis of a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 5 (mGluR5) Receptor via Dynamic Kinetic Resolution of α-Amino Ketones von González-Bobes, Francisco, Hanson, Ronald, Strotman, Neil, Guo, Zhiwei, Goswami, Animesh

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Asymmetric Synthesis of the Cyclohexyl Fragment in RORγt Inhibitor (BMS-986251) Enabled by a Dynamic Kinetic Resolution of Hageman’s Ester von Gallagher, William P., Coombs, John R., Guerrero, Carlos A., Mudryk, Boguslaw M., Katipally, Kishta, Joe, Candice L., Rupasinghe, Sanjeewa, Zhu, Jason, González-Bobes, Francisco

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Bis(pyridine)iodonium Tetrafluoroborate (IPy2BF4): A Versatile Oxidizing Reagent von Barluenga, José, González-Bobes, Francisco, Murguía, Marcelo C., Ananthoju, Sreenivasa R., González, José M.

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Enzymatic reduction of α-substituted ketones with concomitant dynamic kinetic resolution von Hanson, Ronald L., Guo, Zhiwei, González-Bobes, Francisco, Fenster, Michaël D.B., Goswami, Animesh

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New Iodination Reactions of Saturated Hydrocarbons von Barluenga, José, Campos-Gómez, Esther, Rodríguez, David, González-Bobes, Francisco, González, José M.

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Radical Perfluoroalkylation of Arenes via Carbanion Intermediates von Hernandez, Lucas W, Gallagher, William P, Guerrero, Carlos A, Gonzalez-Bobes, Francisco, Coombs, John R

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Enantioselective Synthesis of a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 5 (mGluR5) Receptor via Dynamic Kinetic Resolution of [alpha]-Amino Ketones von Gonzalez-Bobes, Francisco, Hanson, Ronald, Strotman, Neil, Guo, Zhiwei, Goswami, Animesh

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Activation of Alkanes upon Reaction with PhI(OAc)2-I2 von Barluenga, José, González-Bobes, Francisco, González, José M.

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Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores von McDaniel, Jade, Farley, Christopher A, Ramirez, Antonio, Sandhu, Bhupinder, Sarjeant, Amy, Shi, Qing, Han, Arthur, Gallagher, William P, Hynes, John, Dhar, T. G. Murali, Gonzalez-Bobes, Francisco, Coombs, John R, Marcoux, David

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