Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers von Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine

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Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease von Irwin, Ronald W, Solinsky, Christine M, Loya, Carlos M, Salituro, Francesco G, Rodgers, Kathleen E, Bauer, Gerhard, Rogawski, Michael A, Brinton, Roberta Diaz

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Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities von Han, Bingsong, Salituro, Francesco G, Blanco, Maria-Jesus

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Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs von Verhein, Kirsten C, Salituro, Francesco G, Ledeboer, Mark W, Fryer, Allison D, Jacoby, David B

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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations von Yen, Katharine, Travins, Jeremy, Wang, Fang, David, Muriel D, Artin, Erin, Straley, Kimberly, Padyana, Anil, Gross, Stefan, DeLaBarre, Byron, Tobin, Erica, Chen, Yue, Nagaraja, Raj, Choe, Sung, Jin, Lei, Konteatis, Zenon, Cianchetta, Giovanni, Saunders, Jeffrey O, Salituro, Francesco G, Quivoron, Cyril, Opolon, Paule, Bawa, Olivia, Saada, Véronique, Paci, Angelo, Broutin, Sophie, Bernard, Olivier A, de Botton, Stéphane, Marteyn, Benoît S, Pilichowska, Monika, Xu, YingXia, Fang, Cheng, Jiang, Fan, Wei, Wentao, Jin, Shengfang, Silverman, Lee, Liu, Wei, Yang, Hua, Dang, Lenny, Dorsch, Marion, Penard-Lacronique, Virginie, Biller, Scott A, Su, Shin-San Michael

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator von Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA(A) receptor positive allosteric modulator von Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.

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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric... von Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Blanco, Maria-Jesus, Belfort, Gabriel M, Dai, Jing, Loya, Carlos M, Ackley, Michael A, Althaus, Alison L, Grossman, Scott J, Hoffmann, Ethan, Doherty, James J, Robichaud, Albert J

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VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease von Mahajan, Sudipta, Hogan, James K, Shlyakhter, Dina, Oh, Luke, Salituro, Francesco G, Farmer, Luc, Hoock, Thomas C

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis von Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G

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SAGE-718: A First-in-Class N‑Methyl‑d‑Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment von Hill, Matthew D., Blanco, Maria-Jesus, Salituro, Francesco G., Bai, Zhu, Beckley, Jacob T., Ackley, Michael A., Dai, Jing, Doherty, James J., Harrison, Boyd L., Hoffmann, Ethan C., Kazdoba, Tatiana M., Lanzetta, David, Lewis, Michael, Quirk, Michael C., Robichaud, Albert J.

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Breakthroughs in neuroactive steroid drug discovery von Blanco, Maria-Jesus, La, Daniel, Coughlin, Quinn, Newman, Caitlin A., Griffin, Andrew M., Harrison, Boyd L., Salituro, Francesco G.

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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo von Popovici-Muller, Janeta, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy M, Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E, Yang, Hua, Straley, Kimberly S, Jin, Shengfang, Kunii, Kaiko, Fantin, Valeria R, Zhang, Shunan, Pan, Qiongqun, Shi, Derek, Biller, Scott A, Su, Shinsan M

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Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity von La, Daniel S, Salituro, Francesco G, Martinez Botella, Gabriel, Griffin, Andrew M, Bai, Zhu, Ackley, Michael A, Dai, Jing, Doherty, James J, Harrison, Boyd L, Hoffmann, Ethan C, Kazdoba, Tatiana M, Lewis, Michael C, Quirk, Michael C, Robichaud, Albert J

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Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C‑21 von Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Shen, Kaisheng, Belfort, Gabriel M, Loya, Carlos M, Ackley, Michael A, Grossman, Scott J, Hoffmann, Ethan, Jia, Shiling, Wang, Jiamiao, Doherty, James J, Robichaud, Albert J

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Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models von Hammond, Rebecca S, Althaus, Alison L, Ackley, Michael A, Maciag, Carla, Martinez Botella, Gabriel, Salituro, Francesco G, Robichaud, Albert J, Doherty, James J

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy von Kung, Charles, Hixon, Jeff, Choe, Sung, Marks, Kevin, Gross, Stefan, Murphy, Erin, DeLaBarre, Byron, Cianchetta, Giovanni, Sethumadhavan, Shalini, Wang, Xiling, Yan, Shunqi, Gao, Yi, Fang, Cheng, Wei, Wentao, Jiang, Fan, Wang, Shaohui, Qian, Kevin, Saunders, Jeff, Driggers, Ed, Woo, Hin Koon, Kunii, Kaiko, Murray, Stuart, Yang, Hua, Yen, Katharine, Liu, Wei, Cantley, Lewis C., Vander Heiden, Matthew G., Su, Shinsan M., Jin, Shengfang, Salituro, Francesco G., Dang, Lenny

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Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive alloste... von Martin, Brandon S., Martinez-Botella, Gabriel, Loya, Carlos M., Salituro, Francesco G., Robichaud, Albert J., Huntsman, Molly M., Ackley, Mike A., Doherty, James J., Corbin, Joshua G.

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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor von Duffy, John P, Harrington, Edmund M, Salituro, Francesco G, Cochran, John E, Green, Jeremy, Gao, Huai, Bemis, Guy W, Evindar, Ghotas, Galullo, Vincent P, Ford, Pamella J, Germann, Ursula A, Wilson, Keith P, Bellon, Steven F, Chen, Guanging, Taslimi, Paul, Jones, Peter, Huang, Cassey, Pazhanisamy, S, Wang, Yow-Ming, Murcko, Mark A, Su, Michael S.S

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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole von Wang, Tiansheng, Duffy, John P, Wang, Jian, Halas, Summer, Salituro, Francesco G, Pierce, Albert C, Zuccola, Harmon J, Black, James R, Hogan, James K, Jepson, Scott, Shlyakter, Dina, Mahajan, Sudipta, Gu, Yong, Hoock, Thomas, Wood, Mark, Furey, Brinley F, Frantz, J. Daniel, Dauffenbach, Lisa M, Germann, Ursula A, Fan, Bin, Namchuk, Mark, Bennani, Youssef L, Ledeboer, Mark W

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