Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection von Tran, Thien-Duc, Pryde, David C., Jones, Peter, Adam, Fiona M., Benson, Neil, Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Gardner, Iain, Jones, Hannah M., Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy

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Acidic triazoles as soluble guanylate cyclase stimulators von Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.

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Discovery of a highly potent series of TLR7 agonists von Jones, Peter, Pryde, David C., Tran, Thien-Duc, Adam, Fiona M., Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy

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Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors von Glossop, Melanie S., Bazin, Richard J., Dack, Kevin N., Fox, David N.A., MacDonald, Graeme A., Mills, Mark, Owen, Dafydd R., Phillips, Chris, Reeves, Keith A., Ringer, Tracy J., Strang, Ross S., Watson, Christine A.L.

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A rapid injection NMR study of the chelation controlled Mukaiyama aldol addition: TiCl4 versus LiClO4 as the Lewis acid von Reetz, Manfred T, Raguse, Burkhard, Marth, Charles F, Hügel, Helmut M, Bach, Thorsten, Fox, David N.A

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Metallation of benzylic amines via amine-borane complexes von Ebden, Mark R., Simpkins, Nigel S., Fox, David N.A.

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The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot von Andrews, David M, Broad, Laura M, Edwards, Paul J, Fox, David N. A, Gallagher, Timothy, Garland, Stephen L, Kidd, Richard, Sweeney, Joseph B

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Asymmetric Synthesis of Cyclic Ethers by Rearrangement of Oxonium Ylides Generated from Chiral Copper Carbenoids von Clark, J.Stephen, Fretwell, Mark, Whitlock, Gavin A., Burns, Christopher J., Fox, David N.A.

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Carbon-carbon bond formation catalyzed by lithium perchlorate in dichloromethane von Reetz, Manfred T., Fox, David N.A.

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1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von TOLLEFSON, Michael B, ACKER, Brad A, JACOBSEN, E. J, HUGHES, Robert O, WALKER, John K, FOX, David N. A, PALMER, Michael J, FREEMAN, Sandra K, YING YU, BOND, Brian R

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1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von Tollefson, Michael B, Acker, Brad A, Jacobsen, E J, Hughes, Robert O, Walker, John K, Fox, David N A, Palmer, Michael J, Freeman, Sandra K, Yu, Ying, Bond, Brian R

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors von Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung

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1-(2-Ethoxyethyl)-1 H-pyrazolo[4,3- d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von Tollefson, Michael B., Acker, Brad A., Jacobsen, E.J., Hughes, Robert O., Walker, John K., Fox, David N.A., Palmer, Michael J., Freeman, Sandra K., Yu, Ying, Bond, Brian R.

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1-(2-(2,2,2-Trifluoroethoxy)ethyl-1 H-pyrazolo[4,3- d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von Tollefson, Michael B., Acker, Brad A., Jacobsen, E.J., Hughes, Robert O., Walker, John K., Fox, David N.A., Palmer, Michael J., Freeman, Sandra K., Yu, Ying, Bond, Brian R.

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The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection von Pryde, David C., Tran, Thien-Duc, Jones, Peter, Parsons, Gemma C., Bish, Gerwyn, Adam, Fiona M., Smith, Mya C., Middleton, Donald S., Smith, Nick N., Calo, Frederick, Hay, Duncan, Paradowski, Michael, Proctor, Katie J. W., Parkinson, Tanya, Laxton, Carl, Fox, David N. A., Horscroft, Nigel J., Ciaramella, Giuseppe, Jones, Hannah M., Duckworth, Jonathan, Benson, Neil, Harrison, Anthony, Webster, Rob

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Asymmetric synthesis via electrophile-mediated cyclisations von Fox, David N.A., Gallagher, Timothy

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Activation of benzylic amines towards regioselective metallation by borane complex formation von Ebden, Mark R., Simpkins, Nigel S., Fox, David N.A.

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Enantioselective synthesis of pumiliotoxin 251D. A strategy employing an allene-based electrophile-mediated cyclization von Fox, David N. A, Lathbury, David, Mahon, Mary F, Molloy, Kieran C, Gallagher, Timothy

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Diastereoselective and Enantioselective Substitution Reactions of an Isoindoline-Borane Complex von Blake, Alexander J., Ebden, Mark R., Fox, David N. A., Li, Wan-Sheung, Simpkins, Nigel S.

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The diastereoselective and enantioselective substitution reactions of an isoindoline–borane complex von Ariffin, Azhar, Blake, Alexander J., Ebden, Mark R., Li, Wan-Sheung, Simpkins, Nigel S., Fox, David N. A.

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