Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy von Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K

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The Tuberculosis Drug Accelerator at year 10: what have we learned? von Aldridge, Bree B., Barros-Aguirre, David, Barry, Clifton E., Bates, Robert H., Berthel, Steven J., Boshoff, Helena I., Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B., Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A., Kempf, Dale J., Lelièvre, Joël, Lenaerts, Anne J., McNamara, Case W., Mizrahi, Valerie, Nathan, Carl, Olsen, David B., Parish, Tanya, Petrassi, H. Michael, Pym, Alexander, Rhee, Kyu Y., Robertson, Gregory T., Rock, Jeremy Michael, Rubin, Eric J., Russell, Betsy, Russell, David G., Sacchettini, James C., Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M., Warner, Peter, Wyatt, Paul Graham, Yuan, Ying

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In vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 von Vassilev, Lyubomir T., Vu, Binh T., Graves, Bradford, Carvajal, Daisy, Podlaski, Frank, Filipovic, Zoran, Kong, Norman, Kammlott, Ursula, Lukacs, Christine, Klein, Christian, Fotouhi, Nader, Liu, Emily A.

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A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum von Sarathy, Jansy P, Xie, Min, Jones, Richard M, Chang, Adrienne, Osiecki, Paulina, Weiner, Danielle, Tsao, Wen-Shan, Dougher, Maureen, Blanc, Landry, Fotouhi, Nader, Via, Laura E, Barry, 3rd, Clifton E, De Vlaminck, Iwijn, Sherman, David R, Dartois, Véronique A

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The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection von Gordon, Oren, Dikeman, Dustin A, Ortines, Roger V, Wang, Yu, Youn, Christine, Mumtaz, Mohammed, Orlando, Nicholas, Zhang, Jeffrey, Patel, Aman M, Gough, Ethan, Kaushik, Amit, Nuermberger, Eric L, Upton, Anna M, Fotouhi, Nader, Miller, Lloyd S, Archer, Nathan K

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A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage von DAOUTI, Sherif, LI, Wen-Hui, HONGJIN BIAN, REIDHAAR-OLSON, John F, BLISS, Sarah A, OLIVIER, Andree R, SERGI, Joseph A, FRY, David, DANHO, Waleed, RITLAND, Steve, FOTOUHI, Nader, HEIMBROOK, David, HONG QIAN, HUIFENG NIU, HUANG, Kuo-Sen, HOLMGREN, Janna, LEVIN, Wayne, REIK, Linda, MCGADY, Debra Lucas, GILLESPIE, Paul, PERROTTA, Agostino

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Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis von Xu, Jian, Li, Si-Yang, Almeida, Deepak V, Tasneen, Rokeya, Barnes-Boyle, Kala, Converse, Paul J, Upton, Anna M, Mdluli, Khisimuzi, Fotouhi, Nader, Nuermberger, Eric L

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Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis von Xu, Jian, Converse, Paul J, Upton, Anna M, Mdluli, Khisimuzi, Fotouhi, Nader, Nuermberger, Eric L

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Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis von Almeida, Deepak, Converse, Paul J, Li, Si-Yang, Upton, Anna M, Fotouhi, Nader, Nuermberger, Eric L

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Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model von Li, Si-Yang, Converse, Paul J, Betoudji, Fabrice, Lee, Jin, Mdluli, Khisimuzi, Upton, Anna, Fotouhi, Nader, Nuermberger, Eric L

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Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis von Almeida, Deepak, Li, Si-Yang, Lee, Jin, Hafkin, Barry, Mdluli, Khisimuzi, Fotouhi, Nader, Nuermberger, Eric L

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Combating antimicrobial resistance in malaria, HIV and tuberculosis von Duffey, Maëlle, Shafer, Robert W., Timm, Juliano, Burrows, Jeremy N., Fotouhi, Nader, Cockett, Mark, Leroy, Didier

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Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis von Tasneen, Rokeya, Mortensen, Deborah S, Converse, Paul J, Urbanowski, Michael E, Upton, Anna, Fotouhi, Nader, Nuermberger, Eric, Hawryluk, Natalie

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The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model von Ruelas Castillo, Jennie, Neupane, Pranita, Karanika, Styliani, Krug, Stefanie, Quijada, Darla, Garcia, Andrew, Ayeh, Samuel, Yilma, Addis, Costa, Diego L, Sher, Alan, Fotouhi, Nader, Serbina, Natalya, Karakousis, Petros C

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Relative Contributions of the Novel Diarylquinoline TBAJ-876 and its Active Metabolite to the Bactericidal Activity in a Murine Model of Tuberculosis von Mudde, Saskia E, Ammerman, Nicole C, Ten Kate, Marian T, Fotouhi, Nader, Lotlikar, Manisha U, Bax, Hannelore I, de Steenwinkel, Jurriaan E M

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Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis von Li, Si-Yang, Tyagi, Sandeep, Soni, Heena, Betoudji, Fabrice, Converse, Paul J, Mdluli, Khisimuzi, Upton, Anna M, Fotouhi, Nader, Barros-Aguirre, David, Ballell, Lluís, Jimenez-Navarro, Elena, Nuermberger, Eric L

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Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents von Zhang, Jidong, Lair, Christine, Roubert, Christine, Amaning, Kwame, Barrio, María Belén, Benedetti, Yannick, Cui, Zhicheng, Xing, Zhongliang, Li, Xiaojun, Franzblau, Scott G., Baurin, Nicolas, Bordon-Pallier, Florence, Cantalloube, Cathy, Sans, Stephanie, Silve, Sandra, Blanc, Isabelle, Fraisse, Laurent, Rak, Alexey, Jenner, Lasse B., Yusupova, Gulnara, Yusupov, Marat, Zhang, Junjie, Kaneko, Takushi, Yang, T.J., Fotouhi, Nader, Nuermberger, Eric, Tyagi, Sandeep, Betoudji, Fabrice, Upton, Anna, Sacchettini, James C., Lagrange, Sophie

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Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents von Zhang, Jidong, Lair, Christine, Roubert, Christine, Amaning, Kwame, Barrio, María Belén, Benedetti, Yannick, Cui, Zhicheng, Xing, Zhongliang, Li, Xiaojun, Franzblau, Scott, Baurin, Nicolas, Bordon-Pallier, Florence, Cantalloube, Cathy, Sans, Stephanie, Silve, Sandra, Blanc, Isabelle, Fraisse, Laurent, Rak, Alexey, Jenner, Lasse, Yusupova, Gulnara, Yusupov, Marat, Zhang, Junjie, Kaneko, Takushi, Yang, T.J., Fotouhi, Nader, Nuermberger, Eric, Tyagi, Sandeep, Betoudji, Fabrice, Upton, Anna, Sacchettini, James, Lagrange, Sophie

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GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment von Nuermberger, Eric L, Martínez-Martínez, Maria Santos, Sanz, Olalla, Urones, Beatriz, Esquivias, Jorge, Soni, Heena, Tasneen, Rokeya, Tyagi, Sandeep, Li, Si-Yang, Converse, Paul J, Boshoff, Helena I, Robertson, Gregory T, Besra, Gurdyal S, Abrahams, Katherine A, Upton, Anna M, Mdluli, Khisimuzi, Boyle, Gary W, Turner, Sam, Fotouhi, Nader, Cammack, Nicholas C, Siles, Juan Miguel, Alonso, Marta, Escribano, Jaime, Lelievre, Joel, Rullas-Trincado, Joaquin, Pérez-Herrán, Esther, Bates, Robert H, Maher-Edwards, Gareth, Barros, David, Ballell, Lluís, Jiménez, Elena

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Functionalized Organozinc Reagents in Medicinal Chemistry: Discovery of Novel Drug Candidates von Sidduri, Achyutharao, Tilley, Jefferson W., Fotouhi, Nader

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