Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival von Kettle, Jason G, Alwan, Husam, Bista, Michal, Breed, Jason, Davies, Nichola L, Eckersley, Kay, Fillery, Shaun, Foote, Kevin M, Goodwin, Louise, Jones, David R, Käck, Helena, Lau, Alan, Nissink, J. Willem M, Read, Jon, Scott, James S, Taylor, Ben, Walker, Graeme, Wissler, Lisa, Wylot, Marta

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Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer von Foote, Kevin M, Lau, Alan, Nissink, J Willem M

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Validating Aurora B as an anti-cancer drug target von Girdler, Fiona, Gascoigne, Karen E, Eyers, Patrick A, Hartmuth, Sonya, Crafter, Claire, Foote, Kevin M, Keen, Nicholas J, Taylor, Stephen S

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AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis von WILKINSON, Robert W, ODEDRA, Rajesh, BYTH, Kate F, BARRASS, Nigel C, MUNDT, Kirsten E, FOOTE, Kevin M, HERON, Nicola M, JUNG, Frederic H, MORTLOCK, Andrew A, BOYLE, F. Thomas, GREEN, Stephen, HEATON, Simon P, WEDGE, Stephen R, KEEN, Nicholas J, CRAFTER, Claire, FOSTER, John R, BRADY, Madeleine C, BIGLEY, Alison, BROWN, Elaine

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent von Foote, Kevin M, Nissink, J. Willem M, McGuire, Thomas, Turner, Paul, Guichard, Sylvie, Yates, James W. T, Lau, Alan, Blades, Kevin, Heathcote, Dan, Odedra, Rajesh, Wilkinson, Gary, Wilson, Zena, Wood, Christine M, Jewsbury, Philip J

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Protein–Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase von Norman, Richard A, Schott, Anne-Kathrin, Andrews, David M, Breed, Jason, Foote, Kevin M, Garner, Andrew P, Ogg, Derek, Orme, Jonathon P, Pink, Jennifer H, Roberts, Karen, Rudge, David A, Thomas, Andrew P, Leach, Andrew G

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Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monot... von Foote, Kevin M, Blades, Kevin, Cronin, Anna, Fillery, Shaun, Guichard, Sylvie S, Hassall, Lorraine, Hickson, Ian, Jacq, Xavier, Jewsbury, Philip J, McGuire, Thomas M, Nissink, J. Willem M, Odedra, Rajesh, Page, Ken, Perkins, Paula, Suleman, Abid, Tam, Kin, Thommes, Pia, Broadhurst, Rebecca, Wood, Christine

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An Enantiospecific Polyene Cyclization Initiated by an Enantiomerically Pure Bromonium Ion von Braddock, D. Christopher, Marklew, Jared S., Foote, Kevin M., White, Andrew J. P.

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Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats von Turnbull, Andrew V, Ellershaw, Laraine, Masters, Dave J, Birtles, Susan, Boyer, Scott, Carroll, Debbie, Clarkson, Paul, Loxham, Sue J G, McAulay, Pat, Teague, Joanne L, Foote, Kevin M, Pease, J Elizabeth, Block, Michael H

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Expedient synthesis of biologically important sulfonylmethyl pyrimidines von Blades, Kevin, Demeritt, Julie, Fillery, Shaun, Foote, Kevin M., Greenwood, Ryan, Gregson, Clare, Hassall, Lorraine A., McGuire, Thomas M., Pike, Kurt G., Williams, Emma

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 von Rye, Carl S, Chessum, Nicola E. A, Lamont, Scott, Pike, Kurt G, Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D, Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T, de Billy, Emmanuel, Lynch, Christopher J, Sharp, Swee Y, te Poele, Robert, Fee, Lisa O', Foote, Kevin M, Green, Stephen, Workman, Paul, Jones, Keith

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Note: An Enantiospecific Polyene Cyclization Initiated by an Enantiomerically Pure Bromonium Ion von Braddock, D. Christopher, Marklew, Jared S., Foote, Kevin M., White, Andrew J. P.

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Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase von Guichard, Sylvie M., Brown, Elaine, Odedra, Rajesh, Hughes, Adina, Heathcote, Dan, Barnes, Jen, Lau, Alan, Powell, Steve, Jones, Clifford D., Nissink, Willem, Foote, Kevin M., Jewsbury, Philip J., Pass, Martin

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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity von Foote, Kevin M., Mortlock, Andrew A., Heron, Nicola M., Jung, Frédéric H., Hill, George B., Pasquet, Georges, Brady, Madeleine C., Green, Stephen, Heaton, Simon P., Kearney, Sarah, Keen, Nicholas J., Odedra, Rajesh, Wedge, Stephen R., Wilkinson, Robert W.

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Correction: Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See DOI: 10.1039/c6md00159a von Rye, Carl S, Chessum, Nicola E. A, Lamont, Scott, Pike, Kurt G, Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D, Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T, de Billy, Emmanuel, Lynch, Christopher J, Sharp, Swee Y, te Poele, Robert, Fee, Lisa O', Foote, Kevin M, Green, Stephen, Workman, Paul, Jones, Keith

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Synthetic studies towards the phomactins. Concise syntheses of the tricyclic furanochroman and the oxygenated bicyclo[9.3.1]pentadecane ring systems in phomactin A von Foote, Kevin M, Hayes, Christopher J, John, Matthew P, Pattenden, Gerald

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Fischer synthesis of isomeric thienopyrrole LHRH antagonists von Andrews, David M., Arnould, Jean-Claude, Boutron, Pascal, Délouvrie, Bénédicte, Delvare, Christian, Foote, Kevin M., Hamon, Annie, Harris, Craig S., Lambert-van der Brempt, Christine, Lamorlette, Maryannick, Matusiak, Zbegniew M.

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Discovery and Optimization of a Series of Carbazole Ureas as NPY5 Antagonists for the Treatment of Obesity von Block, Michael H, Boyer, Scott, Brailsford, Wayne, Brittain, David R, Carroll, Debra, Chapman, Steve, Clarke, David S, Donald, Craig S, Foote, Kevin M, Godfrey, Linda, Ladner, Anthony, Marsham, Peter R, Masters, David J, Mee, Christine D, O'Donovan, Michael R, Pease, J. Elizabeth, Pickup, Adrian G, Rayner, John W, Roberts, Andrew, Schofield, Paul, Suleman, Abid, Turnbull, Andrew V

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Synthesis of the Oxygenated Bicyclo[9.3.1]pentadecane Ring System of Phomactin A using Chromium (II)-mediated Macrocyclisation and Ring Closure Metathesis von Foote, Kevin M., John, Matthew, Pattenden, Gerald

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Synthesis and structure–activity relationships of thieno[2,3- b]pyrroles as antagonists of the GnRH receptor von Arnould, Jean Claude, Delouvrié, Bénédicte, Boutron, Pascal, Dossetter, Al G., Foote, Kevin M., Hamon, Annie, Hancox, Urs, Harris, Craig S., Hutton, Mike, Lamorlette, Maryannick, Matusiak, Zbigniew

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