The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies von Rasetti-Escargueil, Christine, Avril, Arnaud, Miethe, Sebastian, Mazuet, Christelle, Derman, Yagmur, Selby, Katja, Thullier, Philippe, Pelat, Thibaut, Urbain, Remi, Fontayne, Alexandre, Korkeala, Hannu, Sesardic, Dorothea, Hust, Michael, Popoff, Michel R

Volltext

A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A von Abache, Toufik, Fontayne, Alexandre, Grenier, Dominique, Jacque, Emilie, Longue, Alain, Dezetter, Anne-Sophie, Souilliart, Béatrice, Chevreux, Guillaume, Bataille, Damien, Chtourou, Sami, Plantier, Jean-Luc

Volltext

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies von Monnet, Céline, Jacque, Emilie, de Romeuf, Christophe, Fontayne, Alexandre, Abache, Toufik, Fournier, Nathalie, Dupont, Gilles, Derache, Delphine, Engrand, Anais, Bauduin, Aurélie, Terrier, Aurélie, Seifert, Alexander, Beghin, Cécile, Longue, Alain, Masiello, Nicholas, Danino, Laetitia, Nogre, Michel, Raia, Anais, Dhainaut, Frederic, Fauconnier, Louis, Togbe, Dieudonnée, Reitinger, Carmen, Nimmerjahn, Falk, Stevens, Wil, Chtourou, Sami, Mondon, Philippe

Volltext

Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B von Miethe, Sebastian, Mazuet, Christelle, Liu, Yvonne, Tierney, Robert, Rasetti-Escargueil, Christine, Avril, Arnaud, Frenzel, André, Thullier, Philippe, Pelat, Thibaut, Urbain, Remi, Fontayne, Alexandre, Sesardic, Dorothea, Hust, Michael, Popoff, Michel Robert

Volltext

The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons von Fontayne, Alexandre, Meiring, Muriel, Lamprecht, Seb, Roodt, Jan, Demarsin, Eddy, Barbeaux, Philippe, Deckmyn, Hans

Volltext

In Vivo Human Single-Chain Fragment Variable Phage Display-Assisted Identification of Galectin-3 as a New Biomarker of Atherosclerosis von Hemadou, Audrey, Fontayne, Alexandre, Laroche-Traineau, Jeanny, Ottones, Florence, Mondon, Philippe, Claverol, Stéphane, Ducasse, Éric, Sanchez, Stéphane, Mohamad, Sarah, Lorenzato, Cyril, Duonor-Cerutti, Martine, Clofent-Sanchez, Gisèle, Jacobin-Valat, Marie-Josée

Volltext

Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody von Derman, Yağmur, Selby, Katja, Miethe, Sebastian, Frenzel, André, Liu, Yvonne, Rasetti-Escargueil, Christine, Avril, Arnaud, Pelat, Thibaut, Urbain, Remi, Fontayne, Alexandre, Thullier, Philippe, Sesardic, Dorothea, Lindström, Miia, Hust, Michael, Korkeala, Hannu

Volltext

Rational humanization of the powerful antithrombotic anti-GPIbα antibody: 6B4 von Fontayne, Alexandre, Vanhoorelbeke, Karen, Pareyn, Inge, Van Rompaey, Isabel, Meiring, Muriel, Lamprecht, Seb, Roodt, Jan, Desmet, Johan, Deckmyn, Hans

Volltext

Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0 von Teylaert, Béatrice, Meurice, Edwige, Bobowski, Marie, Harduin-Lepers, Anne, Gaucher, Christine, Fontayne, Alexandre, Jorieux, Sylvie, Delannoy, Philippe

Volltext

Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies von Bas, Mathilde, Terrier, Aurélie, Jacque, Emilie, Dehenne, Aurélie, Pochet-Béghin, Virginie, Beghin, Cécile, Dezetter, Anne-Sophie, Dupont, Gilles, Engrand, Anaïs, Beaufils, Benjamin, Mondon, Philippe, Fournier, Nathalie, de Romeuf, Christophe, Jorieux, Sylvie, Fontayne, Alexandre, Mars, Lennart T, Monnet, Céline

Volltext

Characterization of monoclonal antibodies by a fast and easy liquid chromatography–mass spectrometry time-of-flight analysis on culture supernatant von Henninot, Antoine, Terrier, Aurelie, Charton, Julie, Urbain, Rémi, Fontayne, Alexandre, Deprez, Benoit, Beghyn, Terence

Volltext

Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin von Respaud, Renaud, Marchand, Denis, Pelat, Thibaut, Tchou-Wong, Kam-Meng, Roy, Chad J., Parent, Christelle, Cabrera, Maria, Guillemain, Joël, Mac Loughlin, Ronan, Levacher, Eric, Fontayne, Alexandre, Douziech-Eyrolles, Laurence, Junqua-Moullet, Alexandra, Guilleminault, Laurent, Thullier, Philippe, Guillot-Combe, Emmanuelle, Vecellio, Laurent, Heuzé-Vourc'h, Nathalie

Volltext

Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine von Bianchini, Elsa P., Sebestyen, Alexandre, Abache, Toufik, Bourti, Yasmine, Fontayne, Alexandre, Richard, Vincent, Tamion, Fabienne, Plantier, Jean‐Luc, Doguet, Fabien, Borgel, Delphine

Volltext

An innovative flow cytometry method to screen human scFv-phages selected by in vivo phage-display in an animal model of atherosclerosis von Hemadou, Audrey, Laroche-Traineau, Jeanny, Antoine, Ségolène, Mondon, Philippe, Fontayne, Alexandre, Le Priol, Yannick, Claverol, Stéphane, Sanchez, Stéphane, Cerutti, Martine, Ottones, Florence, Clofent-Sanchez, Gisèle, Jacobin-Valat, Marie-Josée

Volltext

In Vivo Human Single-Chain Fragment Variable Phage Display-Assisted Identification of Galectin-3 as a New Biomarker of Atherosclerosis von Hemadou, Audrey, Fontayne, Alexandre, Laroche‐Traineau, Jeanny, Ottones, Florence, Mondon, Philippe, Claverol, Stéphane, Ducasse, Éric, Sanchez, Stéphane, Mohamad, Sarah, Lorenzato, Cyril, Duonor-Cérutti, Martine, Clofent-Sanchez, Gisèle, Jacobin-Valat, Marie-Josée

Volltext

Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody von Monnet, Céline, Jorieux, Sylvie, Souyris, Nathalie, Zaki, Ouafa, Jacquet, Alexandra, Fournier, Nathalie, Crozet, Fabien, de Romeuf, Christophe, Bouayadi, Khalil, Urbain, Rémi, Behrens, Christian K, Mondon, Philippe, Fontayne, Alexandre

Volltext

Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions von Monnet, Céline, Jorieux, Sylvie, Urbain, Rémi, Fournier, Nathalie, Bouayadi, Khalil, De Romeuf, Christophe, Behrens, Christian K, Fontayne, Alexandre, Mondon, Philippe

Volltext

The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells von Estupina, Pauline, Fontayne, Alexandre, Barret, Jean-Marc, Kersual, Nathalie, Dubreuil, Olivier, Le Blay, Marion, Pichard, Alexandre, Jarlier, Marta, Pugnière, Martine, Chauvin, Maëva, Chardès, Thierry, Pouget, Jean-Pierre, Deshayes, Emmanuel, Rossignol, Alexis, Abache, Toufik, de Romeuf, Christophe, Terrier, Aurélie, Verhaeghe, Lucie, Gaucher, Christine, Prost, Jean-François, Pèlegrin, André, Navarro-Teulon, Isabelle

Volltext

Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern von Fournier, Nathalie, Jacque, Emilie, Fontayne, Alexandre, Derache, Delphine, Dupont, Gilles, Verhaeghe, Lucie, Baptista, Linda, Dehenne, Aurélie, Dezetter, Anne-Sophie, Terrier, Aurélie, Longue, Alain, Pochet-Beghin, Virginie, Beghin, Cecile, Chtourou, Sami, de Romeuf, Christophe

Volltext

Abstract 2945: Depleting hCCR8 mAb Therapy #2: Selection of candidates for the development of innovative depleting anti CCR8 therapeutic antibodies to control the immunosuppressive... von Maurin, Alice Gentil Dit, Richert, Iseulys, Fernandez, Maria Dolores Garcia, Janvier, Aurélie, Rose, Solene, Jeannelle, Megane, Chraa, Dounia, Dietsch, Camille, Urquia, Pauline, Ruet, Quentin, Schappler, Malaury, Baron, Luc, Ayachi, Safia, Blanchard, Orphée, Franchet, Christel, Fontayne, Alexandre, Vermot-Desroches, Claudine, Schann, Stephan, Lenne, Nathalie

Volltext