Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12 von Fokas, Emmanouil, Allgäuer, Michael, Polat, Bülent, Klautke, Gunther, Grabenbauer, Gerhard G, Fietkau, Rainer, Kuhnt, Thomas, Staib, Ludger, Brunner, Thomas, Grosu, Anca-Ligia, Schmiegel, Wolff, Jacobasch, Lutz, Weitz, Jürgen, Folprecht, Gunnar, Schlenska-Lange, Anke, Flentje, Michael, Germer, Christoph-Thomas, Grützmann, Robert, Schwarzbach, Matthias, Paolucci, Vittorio, Bechstein, Wolf O, Friede, Tim, Ghadimi, Michael, Hofheinz, Ralf-Dieter, Rödel, Claus

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Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial von Fokas, Emmanouil, Liersch, Torsten, Fietkau, Rainer, Hohenberger, Werner, Beissbarth, Tim, Hess, Clemens, Becker, Heinz, Ghadimi, Michael, Mrak, Karl, Merkel, Susanne, Raab, Hans-Rudolf, Sauer, Rolf, Wittekind, Christian, Rödel, Claus

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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer von Nicolas, Adele M., Pesic, Marina, Engel, Esther, Ziegler, Paul K., Diefenhardt, Markus, Kennel, Kilian B., Buettner, Florian, Conche, Claire, Petrocelli, Valentina, Elwakeel, Eiman, Weigert, Andreas, Zinoveva, Anna, Fleischmann, Maximilian, Häupl, Björn, Karakütük, Cem, Bohnenberger, Hanibal, Mosa, Mohammed H., Kaderali, Lars, Gaedcke, Jochen, Ghadimi, Michael, Rödel, Franz, Arkan, Melek C., Oellerich, Thomas, Rödel, Claus, Fokas, Emmanouil, Greten, Florian R.

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Tumor Regression Grading After Preoperative Chemoradiotherapy as a Prognostic Factor and Individual-Level Surrogate for Disease-Free Survival in Rectal Cancer von Fokas, Emmanouil, Ströbel, Philipp, Fietkau, Rainer, Ghadimi, Michael, Liersch, Torsten, Grabenbauer, Gerhard G, Hartmann, Arndt, Kaufmann, Marco, Sauer, Rolf, Graeven, Ullrich, Hoffmanns, Hans, Raab, Hans-Rudolf, Hothorn, Torsten, Wittekind, Christian, Rödel, Claus

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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia von Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

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Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2–dependent angiogenesis in mice von Gordon‐Weeks, Alex N., Lim, Su Y., Yuzhalin, Arseniy E., Jones, Keaton, Markelc, Bostjan, Kim, K. Jin, Buzzelli, Jon N., Fokas, Emmanouil, Cao, Yunhong, Smart, Sean, Muschel, Ruth

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Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis von Mesci, Aruz, Huang, Xiaoyong, Taeb, Samira, Jahangiri, Sahar, Kim, Yohan, Fokas, Emmanouil, Bruce, Jeff, Leong, Hon S, Liu, Stanley K

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Rectal cancer: Neoadjuvant chemoradiotherapy von Rödel, Claus, MD, Hofheinz, Ralf, MD, Fokas, Emmanouil, MD

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Stereotactic Radiation Therapy for Benign Meningioma: Long-Term Outcome in 318 Patients von Fokas, Emmanouil, MD, DPhil, Henzel, Martin, MD, Surber, Gunar, PhD, Hamm, Klaus, MD, Engenhart-Cabillic, Rita, MD

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The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy von Prevo, Remko, Fokas, Emmanouil, Reaper, Philip M., Charlton, Peter A., Pollard, John R., McKenna, W. Gillies, Muschel, Ruth J., Brunner, Thomas B.

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Human papilloma virus load and PD-1/PD-L1, CD8+ and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy von Balermpas, Panagiotis, Martin, Daniel, Wieland, Ulrike, Rave-Fränk, Margret, Strebhardt, Klaus, Rödel, Claus, Fokas, Emmanouil, Rödel, Franz

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The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma von Wang, Lai Mun, Silva, Michael A, D'Costa, Zenobia, Bockelmann, Robin, Soonawalla, Zahir, Liu, Stanley, O'Neill, Eric, Mukherjee, Somnath, McKenna, W Gillies, Muschel, Ruth, Fokas, Emmanouil

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Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer von D'Costa, Zenobia, Jones, Keaton, Azad, Abul, van Stiphout, Ruud, Lim, Su Y, Gomes, Ana L, Kinchesh, Paul, Smart, Sean C, Gillies McKenna, W, Buffa, Francesca M, Sansom, Owen J, Muschel, Ruth J, O'Neill, Eric, Fokas, Emmanouil

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Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer von Martin, Daniel, Rödel, Franz, Winkelmann, Ria, Balermpas, Panagiotis, Rödel, Claus, Fokas, Emmanouil

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Acute toxicities of patients with locally advanced rectal cancer treated with intensified chemoradiotherapy within the CAO/ARO/AIO-12 trial: comparing conventional versus VMAT plan... von Zimmermann, Marcus, Richter, Anne, Weick, Stefan, Exner, Florian, Mantel, Frederick, Diefenhardt, Markus, Fokas, Emmanouil, Kosmala, Rebekka, Flentje, Michael, Polat, Bülent

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C-Reactive Protein-to-Albumin Ratio as Prognostic Marker for Anal Squamous Cell Carcinoma Treated With Chemoradiotherapy von Martin, Daniel, Rödel, Franz, Balermpas, Panagiotis, Winkelmann, Ria, Fokas, Emmanouil, Rödel, Claus

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Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature von FOKAS, Emmanouil, JAE HONG IM, MUSCHEL, Ruth J, HILL, Sally, YAMEEN, Sabira, STRATFORD, Michael, BEECH, John, HACKL, Wolfgang, MAIRA, Sauveur-Michel, BEMHARD, Eric J, GILLIES MCKENNA, W

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Biology of brain metastases and novel targeted therapies: Time to translate the research von Fokas, Emmanouil, Steinbach, Joachim P., Rödel, Claus

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The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies von Fokas, Emmanouil, McKenna, W. Gillies, Muschel, Ruth J.

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Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO‐04 randomized phase 3 rectal cancer trial von Diefenhardt, Markus, Hofheinz, Ralf‐Dieter, Martin, Daniel, Beißbarth, Tim, Arnold, Dirk, Hartmann, Arndt, Grün, Jens, Grützmann, Robert, Liersch, Torsten, Ströbel, Philipp, Grabenbauer, Gerhard G., Rieger, Michael, Fietkau, Rainer, Graeven, Ullrich, Weitz, Jürgen, Folprecht, Gunar, Ghadimi, Michael, Rödel, Franz, Rödel, Claus, Fokas, Emmanouil

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