Modern advances in heterocyclic chemistry in drug discovery von Taylor, Alexandria P, Robinson, Ralph P, Fobian, Yvette M, Blakemore, David C, Jones, Lyn H, Fadeyi, Olugbeminiyi

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Visible‐Light‐Initiated Manganese Catalysis for C−H Alkylation of Heteroarenes: Applications and Mechanistic Studies von Nuhant, Philippe, Oderinde, Martins S., Genovino, Julien, Juneau, Antoine, Gagné, Yohann, Allais, Christophe, Chinigo, Gary M., Choi, Chulho, Sach, Neal W., Bernier, Louise, Fobian, Yvette M., Bundesmann, Mark W., Khunte, Bhagyashree, Frenette, Mathieu, Fadeyi, Olugbeminiyi O.

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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation von Arhancet, Graciela B., Walker, Daniel P., Metz, Sue, Fobian, Yvette M., Heasley, Steven E., Carter, Jeffrey S., Springer, John R., Jones, Darin E., Hayes, Michael J., Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Zweifel, Ben, Moore, William M., Masferrer, Jaime L., Vazquez, Michael L.

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Physiochemical drug properties associated with in vivo toxicological outcomes von Hughes, Jason D., Blagg, Julian, Price, David A., Bailey, Simon, DeCrescenzo, Gary A., Devraj, Rajesh V., Ellsworth, Edmund, Fobian, Yvette M., Gibbs, Michael E., Gilles, Richard W., Greene, Nigel, Huang, Enoch, Krieger-Burke, Teresa, Loesel, Jens, Wager, Travis, Whiteley, Larry, Zhang, Yao

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Acidic triazoles as soluble guanylate cyclase stimulators von Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.

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Visible‐Light‐Initiated Manganese Catalysis for C−H Alkylation of Heteroarenes: Applications and Mechanistic Studies von Nuhant, Philippe, Oderinde, Martins S., Genovino, Julien, Juneau, Antoine, Gagné, Yohann, Allais, Christophe, Chinigo, Gary M., Choi, Chulho, Sach, Neal W., Bernier, Louise, Fobian, Yvette M., Bundesmann, Mark W., Khunte, Bhagyashree, Frenette, Mathieu, Fadeyi, Olugbeminiyi O.

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Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design von Walker, Daniel P., Arhancet, Graciela B., Lu, Hwang-Fun, Heasley, Steven E., Metz, Sue, Kablaoui, Natasha M., Franco, Francisco M., Hanau, Cathleen E., Scholten, Jeffrey A., Springer, John R., Fobian, Yvette M., Carter, Jeffrey S., Xing, Li, Yang, Shengtian, Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Moore, William M., Vazquez, Michael L.

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Driving external chemistry optimization via operations management principles von Bi, F. Christopher, Frost, Heather N., Ling, Xiaolan, Perry, David A., Sakata, Sylvie K., Bailey, Simon, Fobian, Yvette M., Sloan, Leslie, Wood, Anthony

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MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides von Fobian, Yvette M., Freskos, John N., Barta, Thomas E., Bedell, Louis J., Heintz, Robert, Kassab, Darren J., Kiefer, James R., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick, Munie, Grace E., Becker, Daniel P.

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Design of potent inhibitors of human β-secretase. Part 1 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory

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Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Ac... von Hughes, Robert O, Rogier, D. Joseph, Jacobsen, E. Jon, Walker, John K, MacInnes, Alan, Bond, Brian R, Zhang, Lena L, Yu, Ying, Zheng, Yi, Rumsey, Jeanne M, Walgren, Jennie L, Curtiss, Sandra W, Fobian, Yvette M, Heasley, Steven E, Cubbage, Jerry W, Moon, Joseph B, Brown, David L, Acker, Brad A, Maddux, Todd M, Tollefson, Mike B, Mischke, Brent V, Owen, Dafydd R, Freskos, John N, Molyneaux, John M, Benson, Alan G, Blevis-Bal, Rhadika M

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system von Hughes, Robert O., Walker, John K., Cubbage, Jerry W., Fobian, Yvette M., Rogier, D. Joseph, Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Owen, Dafydd R., Jacobsen, E. Jon, Freskos, John N., Molyneaux, John M., Brown, David L., Stallings, William C., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Williams, Jennifer M., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors von Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung

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Design of potent inhibitors of human β-secretase. Part 2 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]py... von Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

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Discovery of a Simple Picomolar Inhibitor of Cholesteryl Ester Transfer Protein von Reinhard, Emily J, Wang, Jane L, Durley, Richard C, Fobian, Yvette M, Grapperhaus, Margaret L, Hickory, Brian S, Massa, Mark A, Norton, Monica B, Promo, Michele A, Tollefson, Michael B, Vernier, William F, Connolly, Daniel T, Witherbee, Bryan J, Melton, Michele A, Regina, Karen J, Smith, Mark E, Sikorski, James A

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Chiral N,N-Disubstituted Trifluoro-3-Amino-2-Propanols Are Potent Inhibitors of Cholesteryl Ester Transfer Protein von Durley, Richard C, Grapperhaus, Margaret L, Hickory, Brian S, Massa, Mark A, Wang, Jane L, Spangler, Dale P, Mischke, Deborah A, Parnas, Barry L, Fobian, Yvette M, Rath, Nigam P, Honda, Dorothy D, Zeng, Ming, Connolly, Daniel T, Heuvelman, Deborah M, Witherbee, Bryan J, Melton, Michele A, Glenn, Kevin C, Krul, Elaine S, Smith, Mark E, Sikorski, James A

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Discovery of Chiral N,N-Disubstituted Trifluoro-3-amino-2-propanols as Potent Inhibitors of Cholesteryl Ester Transfer Protein von Durley, Richard C, Grapperhaus, Margaret L, Massa, Mark A, Mischke, Deborah A, Parnas, Barry L, Fobian, Yvette M, Rath, Nigam P, Honda, Dorothy D, Zeng, Ming, Connolly, Daniel T, Heuvelman, Deborah M, Witherbee, Bryan J, Glenn, Kevin C, Krul, Elaine S, Smith, Mark E, Sikorski, James A

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Conformationally Constrained Substance P Analogues:  The Total Synthesis of a Constrained Peptidomimetic for the Phe7-Phe8 Region von Tong, Yunsong, Fobian, Yvette M, Wu, Meiye, Boyd, Norman D, Moeller, Kevin D

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ChemInform Abstract: Modern Advances in Heterocyclic Chemistry in Drug Discovery von Taylor, Alexandria P., Robinson, Ralph P., Fobian, Yvette M., Blakemore, David C., Jones, Lyn H., Fadeyi, Olugbeminiyi

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