Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates von Pillow, Thomas H, Sadowsky, Jack D, Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R, Ha, Edward, Junutula, Jagath R, Flygare, John A

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Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights von Hewings, David S., Flygare, John A., Bogyo, Matthew, Wertz, Ingrid E.

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Discovery and Evaluation of TLR-Targeted Immune Agonists von Chernyak, Natalia, Bhagwat, Bhagyashree, Naravula, Saraswathi, Chen, Ying, Solban, Nicolas, Zhang, Fan, Kofman, Esther, Raoufi, Fahimeh, Dang, Xibei, Bao, Jianming, Tomazela, Daniela, Baily, Marc, Geierstanger, Bernhard, Flygare, John A., Han, Jin-Hwan, Willingham, Aarron, Seganish, W. Michael

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Antibody-Drug Conjugates for the Treatment of Cancer von Flygare, John A., Pillow, Thomas H., Aristoff, Paul

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Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions von Cao, Wendy, Maza, Johnathan C., Chernyak, Natalia, Flygare, John A., Krska, Shane W., Toste, F. Dean, Francis, Matthew B.

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In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin von Gonciarz, Ryan L., Jiang, Honglin, Tram, Linh, Hugelshofer, Cedric L., Ekpenyong, Oscar, Knemeyer, Ian, Aron, Allegra T., Chang, Christopher J., Flygare, John A., Collisson, Eric A., Renslo, Adam R.

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Activity‐based probes for the multicatalytic proteasome von Hewings, David S., Flygare, John A., Wertz, Ingrid E., Bogyo, Matthew

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Cyclodextrin Reduces Intravenous Toxicity of a Model Compound von Mantik, Priscilla, Xie, Minli, Wong, Harvey, La, Hank, Steigerwalt, Ronald W., Devanaboyina, Uday, Ganem, Geoffrey, Shih, Danny, Flygare, John A., Fairbrother, Wayne J., Chakravarty, Paroma, Russell, David, Fernandez, Gilberto E., Narang, Ajit S.

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Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology von Erickson, Rebecca I, Tarrant, Jacqueline, Cain, Gary, Lewin-Koh, Sock-Cheng, Dybdal, Noel, Wong, Harvey, Blackwood, Elizabeth, West, Kristina, Steigerwalt, Ronald, Mamounas, Michael, Flygare, John A, Amemiya, Kenjie, Dambach, Donna, Fairbrother, Wayne J, Diaz, Dolores

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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus von Lehar, Sophie M., Pillow, Thomas, Xu, Min, Staben, Leanna, Kajihara, Kimberly K., Vandlen, Richard, DePalatis, Laura, Raab, Helga, Hazenbos, Wouter L., Hiroshi Morisaki, J., Kim, Janice, Park, Summer, Darwish, Martine, Lee, Byoung-Chul, Hernandez, Hilda, Loyet, Kelly M., Lupardus, Patrick, Fong, Rina, Yan, Donghong, Chalouni, Cecile, Luis, Elizabeth, Khalfin, Yana, Plise, Emile, Cheong, Jonathan, Lyssikatos, Joseph P., Strandh, Magnus, Koefoed, Klaus, Andersen, Peter S., Flygare, John A., Wah Tan, Man, Brown, Eric J., Mariathasan, Sanjeev

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Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold von Cohen, Frederick, Alicke, Bruno, Elliott, Linda O, Flygare, John A, Goncharov, Tatiana, Keteltas, Stephen F, Franklin, Matthew C, Frankovitz, Stacy, Stephan, Jean-Philippe, Tsui, Vickie, Vucic, Domagoj, Wong, Harvey, Fairbrother, Wayne J

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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates von Staben, Leanna R., Koenig, Stefan G., Lehar, Sophie M., Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Linghu, Xin, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.

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Structure-guided design of a selective BCL-XL inhibitor von Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, Paul, Kersten, Wilhelmus J A, Kulasegaram, Sanji, Moss, Rebecca M, Parisot, John P, Smith, Brian J, Street, Ian P, Yang, Hong, Huang, David C S, Watson, Keith G

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Solid-Phase Synthesis of 2-Aminothiazoles von Kearney, Patrick C, Fernandez, Monica, Flygare, John A

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) von Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J

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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes von Hewings, David S., Heideker, Johanna, Ma, Taylur P., AhYoung, Andrew P., El Oualid, Farid, Amore, Alessia, Costakes, Gregory T., Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliya, Maurer, Till, Schwerdtfeger, Carsten, Forrest, William F., Yu, Kebing, Flygare, John, Bogyo, Matthew, Wertz, Ingrid E.

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Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads von Patel, Akash M, Willingham, Aarron, Cheng, Alan C, Tomazela, Daniela, Bowman, Eddie, Kofman, Esther, Zhang, Fan, Bao, Jianming, Sanzone, Jillian R, Choy, Jonathan W, Flygare, John A, Han, Jin-Hwan, Pradhan, Komal, Kieffer, Madeleine, Chernyak, Natalia, Akbari, Peyman, Liu, Ping, Mehmood, Rimsha, Naravula, Saraswathi, Hollingsworth, Scott A, Bhagwat, Bhagyashree, Lang, Simon B, Seganish, W Michael

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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia von Zheng, Bing, Yu, Shang-Fan, Del Rosario, Geoffrey, Leong, Steven R, Lee, Genee Y, Vij, Rajesh, Chiu, Cecilia, Liang, Wei-Ching, Wu, Yan, Chalouni, Cecile, Sadowsky, Jack, Clark, Vanessa, Hendricks, Angela, Poon, Kirsten Achilles, Chu, Wayne, Pillow, Thomas, Schutten, Melissa M, Flygare, John, Polson, Andrew G

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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity von Wei, BinQing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Chuh, Josefa, Kozak, Katherine R, Liu, Yichin, Yu, Shang-Fan, Lau, Jeff, Li, Guangmin, Phillips, Gail D, Leipold, Doug, Kamath, Amrita, Su, Dian, Xu, Keyang, Eigenbrot, Charles, Steinbacher, Stefan, Ohri, Rachana, Raab, Helga, Staben, Leanna R, Zhao, Guiling, Flygare, John A, Pillow, Thomas H, Verma, Vishal, Masterson, Luke A, Howard, Philip W, Safina, Brian

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Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering von Pillow, Thomas H, Tien, Janet, Parsons-Reponte, Kathryn L, Bhakta, Sunil, Li, Hao, Staben, Leanna R, Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D, Su, Dian, Wu, Elmer, Spencer, Susan D, Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R, Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D, Scheller, Richard H, Polakis, Paul, Sliwkowski, Mark X, Flygare, John A, Junutula, Jagath R

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