Codon-specific translation reprogramming promotes resistance to targeted therapy von Rapino, Francesca, Delaunay, Sylvain, Rambow, Florian, Zhou, Zhaoli, Tharun, Lars, De Tullio, Pascal, Sin, Olga, Shostak, Kateryna, Schmitz, Sebastian, Piepers, Jolanda, Ghesquière, Bart, Karim, Latifa, Charloteaux, Benoit, Jamart, Diane, Florin, Alexandra, Lambert, Charles, Rorive, Andrée, Jerusalem, Guy, Leucci, Eleonora, Dewaele, Michael, Vooijs, Marc, Leidel, Sebastian A., Georges, Michel, Voz, Marianne, Peers, Bernard, Büttner, Reinhard, Marine, Jean-Christophe, Chariot, Alain, Close, Pierre

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Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition von Henssen, Anton, Althoff, Kristina, Odersky, Andrea, Beckers, Anneleen, Koche, Richard, Speleman, Frank, Schäfers, Simon, Bell, Emma, Nortmeyer, Maike, Westermann, Frank, De Preter, Katleen, Florin, Alexandra, Heukamp, Lukas, Spruessel, Annika, Astrahanseff, Kathy, Lindner, Sven, Sadowski, Natalie, Schramm, Alexander, Astorgues-Xerri, Lucile, Riveiro, Maria E, Eggert, Angelika, Cvitkovic, Esteban, Schulte, Johannes H

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Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer von Delaunay, Sylvain, Rapino, Francesca, Tharun, Lars, Zhou, Zhaoli, Heukamp, Lukas, Termathe, Martin, Shostak, Kateryna, Klevernic, Iva, Florin, Alexandra, Desmecht, Hadrien, Desmet, Christophe J, Nguyen, Laurent, Leidel, Sebastian A, Willis, Anne E, Büttner, Reinhard, Chariot, Alain, Close, Pierre

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NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas von Meder, Lydia, König, Katharina, Ozretić, Luka, Schultheis, Anne M., Ueckeroth, Frank, Ade, Carsten P., Albus, Kerstin, Boehm, Diana, Rommerscheidt‐Fuss, Ursula, Florin, Alexandra, Buhl, Theresa, Hartmann, Wolfgang, Wolf, Jürgen, Merkelbach‐Bruse, Sabine, Eilers, Martin, Perner, Sven, Heukamp, Lukas C., Buettner, Reinhard

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The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids von Duong, Hong Quan, Nemazanyy, Ivan, Rambow, Florian, Tang, Seng Chuan, Delaunay, Sylvain, Tharun, Lars, Florin, Alexandra, Büttner, Reinhard, Vandaele, Daniel, Close, Pierre, Marine, Jean-Christophe, Shostak, Kateryna, Chariot, Alain

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The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage von Shostak, Kateryna, Jiang, Zheshen, Charloteaux, Benoit, Mayer, Alice, Habraken, Yvette, Tharun, Lars, Klein, Sebastian, Xu, Xinyi, Duong, Hong Quan, Vislovukh, Andrii, Close, Pierre, Florin, Alexandra, Rambow, Florian, Marine, Jean-Christophe, Büttner, Reinhard, Chariot, Alain

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Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer von Kloth, Michael, Ruesseler, Vanessa, Engel, Christoph, Koenig, Katharina, Peifer, Martin, Mariotti, Erika, Kuenstlinger, Helen, Florin, Alexandra, Rommerscheidt-Fuss, Ursula, Koitzsch, Ulrike, Wodtke, Claudia, Ueckeroth, Frank, Holzapfel, Stefanie, Aretz, Stefan, Propping, Peter, Loeffler, Markus, Merkelbach-Bruse, Sabine, Odenthal, Margarete, Friedrichs, Nicolaus, Heukamp, Lukas Carl, Zander, Thomas, Buettner, Reinhard

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Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine von Ladang, Aurélie, Rapino, Francesca, Heukamp, Lukas C, Tharun, Lars, Shostak, Kateryna, Hermand, Damien, Delaunay, Sylvain, Klevernic, Iva, Jiang, Zheshen, Jacques, Nicolas, Jamart, Diane, Migeot, Valérie, Florin, Alexandra, Göktuna, Serkan, Malgrange, Brigitte, Sansom, Owen J, Nguyen, Laurent, Büttner, Reinhard, Close, Pierre, Chariot, Alain

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Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC von Volz, Caroline, Breid, Sara, Selenz, Carolin, Zaplatina, Alina, Golfmann, Kristina, Meder, Lydia, Dietlein, Felix, Borchmann, Sven, Chatterjee, Sampurna, Siobal, Maike, Schöttle, Jakob, Florin, Alexandra, Koker, Mirjam, Nill, Marieke, Ozretić, Luka, Uhlenbrock, Niklas, Smith, Steven, Büttner, Reinhard, Miao, Hui, Wang, Bingcheng, Reinhardt, H. Christian, Rauh, Daniel, Hallek, Michael, Acker-Palmer, Amparo, Heukamp, Lukas C., Ullrich, Roland T.

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Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer von CHATTERJEE, Sampurna, WIECZOREK, Caroline, ULLRICH, Roland T, SCHOTTLE, Jakob, SIOBAL, Maike, HINZE, Yvonne, FRANZ, Thomas, FLORIN, Alexandra, ADAMCZAK, Joanna, HEUKAMP, Lukas C, NEUMAIER, Bernd

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Hippo Signaling Mediates Proliferation, Invasiveness, and Metastatic Potential of Clear Cell Renal Cell Carcinoma von Schütte, Ute, Bisht, Savita, Heukamp, Lukas C, Kebschull, Moritz, Florin, Alexandra, Haarmann, Jens, Hoffmann, Per, Bendas, Gerd, Buettner, Reinhard, Brossart, Peter, Feldmann, Georg

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Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model von König, Katharina, Meder, Lydia, Kröger, Cornelia, Diehl, Linda, Florin, Alexandra, Rommerscheidt-Fuss, Ursula, Kahl, Philip, Wardelmann, Eva, Magin, Thomas M, Buettner, Reinhard, Heukamp, Lukas C

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Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth von Hahne, Jens Claus, Okuducu, Ali Fuat, Kaminski, Annette, Florin, Alexandra, Soncin, Fabrice, Wernert, Nicolas

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Stromal expression of invasion‐promoting, matrix‐degrading proteases MMP‐1 and ‐9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers von Behrens, Peter, Mathiak, Micaela, Mangold, Elisabeth, Kirdorf, Simona, Wellmann, Axel, Fogt, Franz, Rothe, Marcus, Florin, Alexandra, Wernert, Nicolas

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Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer von Meder, Lydia, Schuldt, Philipp, Thelen, Martin, Schmitt, Anna, Dietlein, Felix, Klein, Sebastian, Borchmann, Sven, Wennhold, Kerstin, Vlasic, Ignacija, Oberbeck, Sebastian, Riedel, Richard, Florin, Alexandra, Golfmann, Kristina, Schlößer, Hans A, Odenthal, Margarete, Buettner, Reinhard, Wolf, Juergen, Hallek, Michael, Herling, Marco, von Bergwelt-Baildon, Michael, Reinhardt, H Christian, Ullrich, Roland T

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Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors von Ortiz-Cuaran, Sandra, Scheffler, Matthias, Plenker, Dennis, Dahmen, Llona, Scheel, Andreas H, Fernandez-Cuesta, Lynnette, Meder, Lydia, Lovly, Christine M, Persigehl, Thorsten, Merkelbach-Bruse, Sabine, Bos, Marc, Michels, Sebastian, Fischer, Rieke, Albus, Kerstin, König, Katharina, Schildhaus, Hans-Ulrich, Fassunke, Jana, Ihle, Michaela A, Pasternack, Helen, Heydt, Carina, Becker, Christian, Altmüller, Janine, Ji, Hongbin, Müller, Christian, Florin, Alexandra, Heuckmann, Johannes M, Nuernberg, Peter, Ansén, Sascha, Heukamp, Lukas C, Berg, Johannes, Pao, William, Peifer, Martin, Buettner, Reinhard, Wolf, Jürgen, Thomas, Roman K, Sos, Martin L

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LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia von Nguyen, Phuong-Hien, Fedorchenko, Oleg, Rosen, Natascha, Koch, Maximilian, Barthel, Romy, Winarski, Tomasz, Florin, Alexandra, Wunderlich, F. Thomas, Reinart, Nina, Hallek, Michael

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Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization von Chen, Dawei, Nemazanyy, Ivan, Peulen, Olivier, Shostak, Kateryna, Xu, Xinyi, Tang, Seng Chuan, Wathieu, Caroline, Turchetto, Silvia, Tielens, Sylvia, Nguyen, Laurent, Close, Pierre, Desmet, Christophe, Klein, Sebastian, Florin, Alexandra, Büttner, Reinhard, Petrellis, Georgios, Dewals, Benjamin, Chariot, Alain

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Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer von Golfmann, Kristina, Meder, Lydia, Koker, Mirjam, Volz, Caroline, Borchmann, Sven, Tharun, Lars, Dietlein, Felix, Malchers, Florian, Florin, Alexandra, Büttner, Reinhard, Rosen, Neal, Rodrik-Outmezguine, Vanessa, Hallek, Michael, Ullrich, Roland T.

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Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer von Lovly, Christine M, McDonald, Nerina T, Chen, Heidi, Ortiz-Cuaran, Sandra, Heukamp, Lukas C, Yan, Yingjun, Florin, Alexandra, Ozretić, Luka, Lim, Diana, Wang, Lu, Chen, Zhao, Chen, Xi, Lu, Pengcheng, Paik, Paul K, Shen, Ronglai, Jin, Hailing, Buettner, Reinhard, Ansén, Sascha, Perner, Sven, Brockmann, Michael, Bos, Marc, Wolf, Jürgen, Gardizi, Masyar, Wright, Gavin M, Solomon, Benjamin, Russell, Prudence A, Rogers, Toni-Maree, Suehara, Yoshiyuki, Red-Brewer, Monica, Tieu, Rudy, de Stanchina, Elisa, Wang, Qingguo, Zhao, Zhongming, Johnson, David H, Horn, Leora, Wong, Kwok-Kin, Thomas, Roman K, Ladanyi, Marc, Pao, William

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