Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries von Dyson, Michael R, Masters, Edward, Pazeraitis, Deividas, Perera, Rajika L, Syrjanen, Johanna L, Surade, Sachin, Thorsteinson, Nels, Parthiban, Kothai, Jones, Philip C, Sattar, Maheen, Wozniak-Knopp, Gordana, Rueker, Florian, Leah, Rachael, McCafferty, John

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Integrating In Silico and In Vitro Tools for Optimized Antibody Development-Design of Therapeutic Anti-oxMIF Antibodies von Rossmueller, Gregor, Mirkina, Irina, Thiele, Michael, Puchol Tarazona, Alejandro, Rueker, Florian, Kerschbaumer, Randolf J, Schinagl, Alexander

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Enhancement and Analysis of Human Antiaflatoxin B1 (AFB1) scFv Antibody–Ligand Interaction Using Chain Shuffling von Rangnoi, Kuntalee, Choowongkomon, Kiattawee, O’Kennedy, Richard, Rüker, Florian, Yamabhai, Montarop

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Easy assessment of the avidity of polyclonal allergen‐specific serum antibodies von Strobl, Maria R., Demir, Hilal, Wozniak‐Knopp, Gordana, Wangorsch, Andrea, Rüker, Florian, Bohle, Barbara

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Guest Editor’s introduction – Antibody Engineering von Rüker, Florian

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A C-terminal interdomain disulfide bond significantly stabilizes the Fc fragment of IgG von Wozniak-Knopp, Gordana, Rüker, Florian

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Structural studies of several clinically important oncology drugs in complex with human serum albumin von Wang, Zhong-min, Ho, Joseph X., Ruble, John R., Rose, John, Rüker, Florian, Ellenburg, Melanie, Murphy, Robert, Click, James, Soistman, Elizabeth, Wilkerson, Leslie, Carter, Daniel C.

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Efficient spontaneous site-selective cysteine-mediated toxin attachment within a structural loop of antibodies von Stadlmayr, Gerhard, Stracke, Florian, Stadlbauer, Katharina, Rybka, Jakub, Dickgiesser, Stephan, Rasche, Nicolas, Becker, Stefan, Toleikis, Lars, Rüker, Florian, Knopp, Gordana Wozniak

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Development of a Cytotoxic Antibody–Drug Conjugate Targeting Membrane Immunoglobulin E-Positive Cells von Rodak, Aleksandra, Stadlbauer, Katharina, Bobbili, Madhusudhan Reddy, Smrzka, Oskar, Rüker, Florian, Wozniak Knopp, Gordana

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Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds von Wozniak-Knopp, Gordana, Stadlmann, Johannes, Rüker, Florian

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Stabilization of soluble high‐affinity T‐cell receptor with de novo disulfide bonds von Sádio, Flávio, Stadlmayr, Gerhard, Stadlbauer, Katharina, Gräf, Maximilian, Scharrer, Agnes, Rüker, Florian, Wozniak‐Knopp, Gordana

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Methods for Construction of Yeast Display Libraries of Four-Domain T-Cell Receptors von Sádio, Flávio, Stadlmayr, Gerhard, Eibensteiner, Katja, Stadlbauer, Katharina, Rüker, Florian, Wozniak-Knopp, Gordana

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Element labeling of antibody fragments for ICP-MS based immunoassays von Mairinger, Teresa, Wozniak-Knopp, Gordana, Rüker, Florian, Koellensperger, Gunda, Hann, Stephan

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Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments von Wozniak-Knopp, Gordana, Stadlmayr, Gerhard, Perthold, Jan Walther, Stadlbauer, Katharina, Woisetschläger, Maximilian, Sun, Haijun, Rüker, Florian

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Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies von Lobner, Elisabeth, Humm, Anne-Sophie, Göritzer, Kathrin, Mlynek, Georg, Puchinger, Martin G., Hasenhindl, Christoph, Rüker, Florian, Traxlmayr, Michael W., Djinović-Carugo, Kristina, Obinger, Christian

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Construction of a Stability Landscape of the CH3 Domain of Human IgG1 by Combining Directed Evolution with High Throughput Sequencing von Traxlmayr, Michael W., Hasenhindl, Christoph, Hackl, Matthias, Stadlmayr, Gerhard, Rybka, Jakub D., Borth, Nicole, Grillari, Johannes, Rüker, Florian, Obinger, Christian

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A Tetravalent Biparatopic Antibody Causes Strong HER2 Internalization and Inhibits Cellular Proliferation von Benedetti, Filippo, Stadlbauer, Katharina, Stadlmayr, Gerhard, Rüker, Florian, Wozniak-Knopp, Gordana

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Binding Characteristic of Various Antibody Formats Against Aflatoxins von Rangnoi, Kuntalee, Rüker, Florian, Wozniak-Knopp, Gordana, Cvak, Barbara, O’Kennedy, Richard, Yamabhai, Montarop

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Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast von Traxlmayr, Michael W., Faissner, Maximilian, Stadlmayr, Gerhard, Hasenhindl, Christoph, Antes, Bernhard, Rüker, Florian, Obinger, Christian

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Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments von Jez, Jakub, Antes, Bernhard, Castilho, Alexandra, Kainer, Manuela, Wiederkum, Susanne, Grass, Josephine, Rüker, Florian, Woisetschläger, Max, Steinkellner, Herta

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