Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture von Savile, Christopher K., Janey, Jacob M., Mundorff, Emily C., Moore, Jeffrey C., Tam, Sarena, Jarvis, William R., Colbeck, Jeffrey C., Krebber, Anke, Fleitz, Fred J., Brands, Jos, Devine, Paul N., Huisman, Gjalt W., Hughes, Gregory J.

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Enantioselective Synthesis of a Dual Orexin Receptor Antagonist von Mangion, Ian K, Sherry, Benjamin D, Yin, Jingjun, Fleitz, Fred J

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Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure von Ruck, Rebecca T, Chen, Qinghao, Rivera, Nelo, Kong, Jongrock, Mangion, Ian K, Tan, Lushi, Fleitz, Fred J

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1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia von Vachal, Petr, Miao, Shouwu, Pierce, Joan M, Guiadeen, Deodial, Colandrea, Vincent J, Wyvratt, Matthew J, Salowe, Scott P, Sonatore, Lisa M, Milligan, James A, Hajdu, Richard, Gollapudi, Anantha, Keohane, Carol A, Lingham, Russell B, Mandala, Suzanne M, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Steinhuebel, Dietrich, Kieczykowski, Gerard R, Fleitz, Fred J, Chapman, Kevin, Athanasopoulos, John, Adam, Gregory, Akyuz, Can D, Jena, Dhirendra K, Lusen, Jeffrey W, Meng, Juncai, Stein, Benjamin D, Xia, Lei, Sherer, Edward C, Hale, Jeffrey J

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Palladium-Catalyzed Synthesis of Aryl Sulfides from Aryl Triflates von Zheng, Nan, McWilliams, J. Christopher, Fleitz, Fred J, Armstrong, Joseph D, Volante, R. P

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Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex von Bassan, Ephraim M, Baxter, Carl A, Beutner, Gregory L, Emerson, Khateeta M, Fleitz, Fred J, Johnson, Simon, Keen, Stephen, Kim, Mary M, Kuethe, Jeffrey T, Leonard, William R, Mullens, Peter R, Muzzio, Daniel J, Roberge, Christopher, Yasuda, Nobuyoshi

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A highly catalytic robust palladium catalyzed cyanation of aryl bromides von Maligres, Peter E., Waters, Marjorie S., Fleitz, Fred, Askin, David

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Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors von Kuethe, Jeffrey T., Zhong, Yong-Li, Alam, Mahbub, Alorati, Anthony D., Beutner, Gregory L., Cai, Dongwei, Fleitz, Fred J., Gibb, Andrew D., Kassim, Amude, Linn, Kathleen, Mancheno, Danny, Marcune, Benjamin, Pye, Philip J., Scott, Jeremy P., Tellers, David M., Xiang, Bangping, Yasuda, Nobuyoshi, Yin, Jingjun, Davies, Ian W.

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Chromatography as an Enabling Technology in Pharmaceutical Process Development:  Expedited Multikilogram Preparation of a Candidate HIV Protease Inhibitor von Welch, Christopher J, Fleitz, Fred, Antia, Firoz, Yehl, Pete, Waters, Robert, Ikemoto, Norihiro, Armstrong, Joseph D, Mathre, David J

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On Pd-Catalyzed Cycloisomerization versus Cycloreduction. A General Strategy for Drimane Synthesis and a Short Total Synthesis of Siccanin von Trost, Barry M, Fleitz, Fred J, Watkins, William J

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Asymmetric bioreduction of α,β-unsaturated nitriles and ketones von Kosjek, Birgit, Fleitz, Fred J., Dormer, Peter G., Kuethe, Jeffrey T., Devine, Paul N.

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A [2 + 2] Cycloaddition Route to Dimethylaminomethylene Vinamidinium Salts von Davies, Ian W, Tellers, David M, Shultz, C. Scott, Fleitz, Fred J, Cai, Dongwei, Sun, Yongkui

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Asymmetric synthesis of cyanohydrin derived from pyridine aldehyde with cross-linked aggregates of hydroxynitrile lyases von Roberge, Christopher, Fleitz, Fred, Pollard, David, Devine, Paul

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The formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinones von Grunwell, John R, Karipides, Anastas, Wigal, Carl T, Heinzman, Stephen W, Parlow, John, Surso, Joan A, Clayton, Laura, Fleitz, Fred J, Daffner, Martin, Stevens, Jonathan E

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Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from Linum us... von Roberge, Christopher, Fleitz, Fred, Pollard, David, Devine, Paul

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Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development von Helmy, Roy, Schafer, Wes, Buhler, Leah, Marcinko, Stephen, Musselman, Brian, Guidry, Erin, Jenkins, Herb, Fleitz, Fred, Welch, Christopher J

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Approaches to installing a N- gem-dimethylmethylene-2-oxazolyl group and application to the synthesis of a second generation HIV protease inhibitor von Ikemoto, Norihiro, Miller, Ross A., Fleitz, Fred J., Liu, Jinchu, Petrillo, Daniel E., Leone, Joseph F., Laquidara, Joseph, Marcune, Benjamin, Karady, Sandor, Armstrong, Joseph D., Volante, Ralph P.

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Targeting ligands for therapeutic compounds von Rozema, David B, Benson, Jonathan D, Wakefield, Darren H, Pei, Tao, Fleitz, Fred, Blokhin, Andrei V, Li, Zhen

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Targeting ligands von Glebocka, Agnieszka, Lawler, Michael, Kumar, Pankaj, Pei, Tao, Altenhofer, Erich, Fleitz, Fred, Li, Zhen

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Targeting ligands von Glebocka, Agnieszka, Lawler, Michael, Kumar, Pankaj, Pei, Tao, Altenhofer, Erich, Fleitz, Fred, Li, Zhen

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