Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases von Clark, James D, Flanagan, Mark E, Telliez, Jean-Baptiste

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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection von Flanagan, Mark E, Blumenkopf, Todd A, Brissette, William H, Brown, Matthew F, Casavant, Jeffrey M, Shang-Poa, Chang, Doty, Jonathan L, Elliott, Eileen A, Fisher, Michael B, Hines, Michael, Kent, Craig, Kudlacz, Elizabeth M, Lillie, Brett M, Magnuson, Kelly S, McCurdy, Sandra P, Munchhof, Michael J, Perry, Bret D, Sawyer, Perry S, Strelevitz, Timothy J, Subramanyam, Chakrapani, Sun, Jianmin, Whipple, David A, Changelian, Paul S

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Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens von Fahnoe, Kelly C, Flanagan, Mark E, Gibson, Glenn, Shanmugasundaram, Veerabahu, Che, Ye, Tomaras, Andrew P

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Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS) von Ratnayake, Anokha S., Flanagan, Mark E., Foley, Timothy L., Hultgren, Scott L., Bellenger, Justin, Montgomery, Justin I., Lall, Manjinder S., Liu, Bo, Ryder, Tim, Kölmel, Dominik K., Shavnya, Andre, Feng, Xidong, Lefker, Bruce, Byrnes, Laura J., Sahasrabudhe, Parag V., Farley, Kathleen A., Chen, Shi, Wan, Jinqiao

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Photoredox cross-electrophile coupling in DNA-encoded chemistry von Kölmel, Dominik K., Ratnayake, Anokha S., Flanagan, Mark E.

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Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids von Kölmel, Dominik K., Loach, Richard P., Knauber, Thomas, Flanagan, Mark E.

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Photocatalytic [2 + 2] Cycloaddition in DNA-Encoded Chemistry von Kölmel, Dominik K, Ratnayake, Anokha S, Flanagan, Mark E, Tsai, Mei-Hsuan, Duan, Cong, Song, Chao

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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Au... von Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray

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The specificity of JAK3 kinase inhibitors von Changelian, Paul S., Moshinsky, Deborah, Kuhn, Cyrille F., Flanagan, Mark E., Munchhof, Michael J., Harris, Thomas M., Whipple, David A., Doty, Jonathan L., Sun, Jianmin, Kent, Craig R., Magnuson, Kelly S., Perregaux, David G., Sawyer, Perry S., Kudlacz, Elizabeth M.

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RASS‐Enabled S/P−C and S−N Bond Formation for DEL Synthesis von Flood, Dillon T., Zhang, Xuejing, Fu, Xiang, Zhao, Zhenxiang, Asai, Shota, Sanchez, Brittany B., Sturgell, Emily J., Vantourout, Julien C., Richardson, Paul, Flanagan, Mark E., Piotrowski, David W., Kölmel, Dominik K., Wan, Jinqiao, Tsai, Mei‐Hsuan, Chen, Jason S., Baran, Phil S., Dawson, Philip E.

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Cyclic Peptide C5aR1 Antagonist Design Using Solution Conformational Analysis Derived from Residual Dipolar Couplings von Farley, Kathleen A., Che, Ye, Lira, Ricardo, Jones, Peter, Papaioannou, Nikolaos, Hayward, Matthew, Flanagan, Mark E., Langille, Jonathan, Liang, Sidney, Pierce, Betsy S., Ciszewski, Gregory, Bonin, Paul, Vincent, Fabien, Ramsey, Simeon, Hepworth, David

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Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity von Zhang, Qingzhou, Jiang, Fan, Zhao, Bingchuan, Lin, Huacan, Tian, Yuan, Xie, Mingsheng, Bai, Guoyun, Gilbert, Adam M., Goetz, Gilles H., Liras, Spiros, Mathiowetz, Alan A., Price, David A., Song, Kun, Tu, Meihua, Wu, Yujie, Wang, Tao, Flanagan, Mark E., Wu, Yun-Dong, Li, Zigang

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Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections von Magee, Thomas V, Brown, Matthew F, Starr, Jeremy T, Ackley, David C, Abramite, Joseph A, Aubrecht, Jiri, Butler, Andrew, Crandon, Jared L, Dib-Hajj, Fadia, Flanagan, Mark E, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Irvine, Rebecca, Kuhn, Michael, Leach, Karen L, Li, Bryan, Lin, Jian, Luke, David R, MacVane, Shawn H, Miller, Alita A, McCurdy, Sandra, McKim, James M, Nicolau, David P, Nguyen, Thuy-Trinh, Noe, Mark C, O’Donnell, John P, Seibel, Scott B, Shen, Yue, Stepan, Antonia F, Tomaras, Andrew P, Wilga, Paul C, Zhang, Li, Xu, Jinfeng, Chen, Jinshan Michael

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RASS‐Enabled S/P−C and S−N Bond Formation for DEL Synthesis von Flood, Dillon T., Zhang, Xuejing, Fu, Xiang, Zhao, Zhenxiang, Asai, Shota, Sanchez, Brittany B., Sturgell, Emily J., Vantourout, Julien C., Richardson, Paul, Flanagan, Mark E., Piotrowski, David W., Kölmel, Dominik K., Wan, Jinqiao, Tsai, Mei‐Hsuan, Chen, Jason S., Baran, Phil S., Dawson, Philip E.

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Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections von Mitton-Fry, Mark J., Arcari, Joel T., Brown, Matthew F., Casavant, Jeffrey M., Finegan, Steven M., Flanagan, Mark E., Gao, Hongying, George, David M., Gerstenberger, Brian S., Han, Seungil, Hardink, Joel R., Harris, Thomas M., Hoang, Thuy, Huband, Michael D., Irvine, Rebecca, Lall, Manjinder S., Megan Lemmon, M., Li, Chao, Lin, Jian, McCurdy, Sandra P., Mueller, John P., Mullins, Lisa, Niosi, Mark, Noe, Mark C., Pattavina, David, Penzien, Joseph, Plummer, Mark S., Risley, Hud, Schuff, Brandon P., Shanmugasundaram, Veerabahu, Starr, Jeremy T., Sun, Jianmin, Winton, Jennifer, Young, Jennifer A.

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Synthetic Studies on Quinocarcin: Total Synthesis of (.+-.)-Quinocarcinamide via Dipole Cycloaddition of an Azomethine Ylide Generated by NBS Oxidation von Flanagan, Mark E, Williams, Robert M

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A Generic Foreground Calibration Algorithm For ADCs With Nonlinear Impairments von Salib, Armia, Flanagan, Mark F., Cardiff, Barry

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Wireless-Powered Distributed Spatial Modulation With Energy Recycling and Finite-Energy Storage von Narayanan, Sandeep, Shikh-Bahaei, Mohammad, Hou, Jiancao, Flanagan, Mark F.

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Process Development of a Novel Azetidinyl Ketolide Antibiotic von Li, Bryan, Magee, Thomas V, Buzon, Richard A, Widlicka, Daniel W, Bill, Dave R, Brandt, Thomas, Cao, Xiaoping, Coutant, Michael, Dou, Haijian, Granskog, Karl, Flanagan, Mark E, Hayward, Cheryl M, Li, Bin, Liu, Fengwei, Liu, Wei, Nguyen, Thuy-Trinh, Raggon, Jeffrey W, Rose, Peter, Rainville, Joseph, Reilly, Usa Datta, Shen, Yue, Sun, Jianmin, Wilcox, Glenn E

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New analyses of MIC90 data to aid antibacterial drug discovery von Brown, Matthew F., Gupta, Rishi R., Kuhn, Max, Flanagan, Mark E., Mitton-Fry, Mark

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