Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitr... von Dubowchik, Gene M, Firestone, Raymond A, Padilla, Linda, Willner, David, Hofstead, Sandra J, Mosure, Kathleen, Knipe, Jay O, Lasch, Shirley J, Trail, Pamela A

Volltext

The Low Energy of Concert in Many Symmetry-Allowed Cycloadditions Supports a Stepwise-Diradical Mechanism von Firestone, Raymond A.

Volltext

Lessons from 54 years of pharmaceutical research von Firestone, Raymond A.

Volltext

Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition von Kosic, Milica, Arsikin-Csordas, Katarina, Paunovic, Verica, Firestone, Raymond A., Ristic, Biljana, Mircic, Aleksandar, Petricevic, Sasa, Bosnjak, Mihajlo, Zogovic, Nevena, Mandic, Milos, Bumbasirevic, Vladimir, Trajkovic, Vladimir, Harhaji-Trajkovic, Ljubica

Volltext

Low-Density Lipoprotein as a Vehicle for Targeting Antitumor Compounds to Cancer Cells von Firestone, Raymond A

Volltext

Cathepsin B Cleavable Novel Prodrug Ac-Phe-Lys-PABC-ADM Enhances Efficacy at Reduced Toxicity in Treating Gastric Cancer Peritoneal Carcinomatosis: An Experimental Study von SHAO, Li-Hua, LIU, Shao-Ping, YAN LI, HOU, Jin-Xuan, ZHANG, Yan-Hua, PENG, Chun-Wei, ZHONG, Yan-Jun, XIONG LIU, LIU, Xiu-Li, HONG, Ya-Ping, FIRESTONE, Raymond A

Volltext

Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study von Wang, Qun, Zhong, Yan-Jun, Yuan, Jing-Ping, Shao, Li-Hua, Zhang, Jue, Tang, Li, Liu, Shao-Ping, Hong, Ya-Ping, Firestone, Raymond A, Li, Yan

Volltext

Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer von Zhang, Jue, Yuan, Jing-Ping, Wang, Qun, Shao, Li-Hua, Liu, Shao-Ping, Firestone, Raymond A, Hong, Ya-Ping, Li, Ji-Guo, Xin, Yan-Chao, Li, Yan

Volltext

Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but red... von Tang, Li, Duan, Rui, Zhong, Yan-jun, Firestone, Raymond A, Hong, Ya-ping, Li, Ji-guo, Xin, Yan-chao, Wu, Han-lin, Li, Yan

Volltext

Studies with vitamin E and β-carotene as single agents do not prove lack of benefit von Firestone, Raymond A.

Volltext

Synthesis of an immunoconjugate of camptothecin von Walker, Michael A, Dubowchik, Gene M, Hofstead, Sandra J, Trail, Pamela A, Firestone, Raymond A

Volltext

Anticancer effects of Ac-Phe-Lys-PABC-doxorubicin via mitochondria-centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC-803 cells von ZHONG, YAN-JUN, LIU, SHAO-PING, FIRESTONE, RAYMOND A, HONG, YA-PING, LI, YAN

Volltext

Lipid‐lowering agents may fight cancer by denying it LDL von Firestone, Raymond A.

Volltext

(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin von Willner, David, Trail, Pamela A, Hofstead, Sandra J, King, H. Dalton, Lasch, Shirley J, Braslawsky, Gary R, Greenfield, Robert S, Kaneko, Takushi, Firestone, Raymond A

Volltext

Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Peptide Linkers:  Inhibition of Aggregation by Methoxytriethyleneglycol Chains von King, H. Dalton, Dubowchik, Gene M, Mastalerz, Harold, Willner, David, Hofstead, Sandra J, Firestone, Raymond A, Lasch, Shirley J, Trail, Pamela A

Volltext

Drug giants hamstrung by timid middle management von Firestone, Raymond A.

Volltext

Induction of cell death by the lysosomotropic detergent MSDH von Li, Wei, Yuan, XiMing, Nordgren, Gunnar, Dalen, Helge, Dubowchik, Gene M., Firestone, Raymond A., Brunk, Ulf T.

Volltext

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin von Dubowchik, Gene M., Firestone, Raymond A.

Volltext

Reply to “Comment on ‘Phantom Activation Volumes'” von Firestone, Raymond A, Swiss, Kevin A

Volltext

Anti-Cancer Effects of Novel Doxorubicin Prodrug PDOX in MCF-7 Breast Cancer Cells von 张珏 何良 耿霞飞 Raymond A. Firestone 洪亚平 李雁

Volltext