New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource von Peña, Imanol, Pilar Manzano, M., Cantizani, Juan, Kessler, Albane, Alonso-Padilla, Julio, Bardera, Ana I., Alvarez, Emilio, Colmenarejo, Gonzalo, Cotillo, Ignacio, Roquero, Irene, de Dios-Anton, Francisco, Barroso, Vanessa, Rodriguez, Ana, Gray, David W., Navarro, Miguel, Kumar, Vinod, Sherstnev, Alexander, Drewry, David H., Brown, James R., Fiandor, Jose M., Julio Martin, J.

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Potent antimalarial 4-pyridones with improved physico-chemical properties von Bueno, José M., Manzano, Pilar, García, María C., Chicharro, Jesús, Puente, Margarita, Lorenzo, Milagros, García, Adolfo, Ferrer, Santiago, Gómez, Rubén M., Fraile, María T., Lavandera, José L., Fiandor, José M., Vidal, Jaume, Herreros, Esperanza, Gargallo-Viola, Domingo

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis von Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition von Wyllie, Susan, Brand, Stephen, Thomas, Michael, De Rycker, Manu, Chung, Chun-wa, Pena, Imanol, Bingham, Ryan P., Bueren-Calabuig, Juan A., Cantizani, Juan, Cebrian, David, Craggs, Peter D., Ferguson, Liam, Goswami, Panchali, Hobrath, Judith, Howe, Jonathan, Jeacock, Laura, Ko, Eun-Jung, Korczynska, Justyna, MacLean, Lorna, Manthri, Sujatha, Martinez, Maria S., Mata-Cantero, Lydia, Moniz, Sonia, Nühs, Andrea, Osuna-Cabello, Maria, Pinto, Erika, Riley, Jennifer, Robinson, Sharon, Rowland, Paul, Simeons, Frederick R. C., Shishikura, Yoko, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Gaza, Elisabet Viayna, Wall, Richard J., Zuccotto, Fabio, Horn, David, Ferguson, Michael A. J., Fairlamb, Alan H., Fiandor, Jose M., Martin, Julio, Gray, David W., Miles, Timothy J., Gilbert, Ian H., Read, Kevin D., Marco, Maria, Wyatt, Paul G.

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Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis von Thomas, Michael, Brand, Stephen, De Rycker, Manu, Zuccotto, Fabio, Lukac, Iva, Dodd, Peter G, Ko, Eun-Jung, Manthri, Sujatha, McGonagle, Kate, Osuna-Cabello, Maria, Riley, Jennifer, Pont, Caterina, Simeons, Frederick, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna, Elisabet, Fiandor, Jose M, Martin, Julio, Wyatt, Paul G, Miles, Timothy J, Read, Kevin D, Marco, Maria, Gilbert, Ian H

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Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform von Norcliffe, Jennifer L., Mina, John G., Alvarez, Emilio, Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo, Valle, Silva Gonzalez-Del, Marco, Maria, Fiandor, José M., Martin, Julio J., Steel, Patrick G., Denny, Paul W.

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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis von Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.

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Synthesis and Structure–Activity Relationships of the Novel Antimalarials 5‑Pyridinyl-4(1H)‑Pyridones von Bueno, José M, Calderon, Félix, Chicharro, Jesús, De la Rosa, Juan C, Díaz, Beatriz, Fernández, Jorge, Fiandor, José M, Fraile, María T, García, Mercedes, Herreros, Esperanza, García-Pérez, Adolfo, Lorenzo, Milagros, Mallo, Araceli, Puente, Margarita, Saadeddin, Anas, Ferrer, Santiago, Angulo-Barturen, Iñigo, Burrows, Jeremy N, León, María L

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Discovery and Optimization of 5‑Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi von Brand, Stephen, Ko, Eun Jung, Viayna, Elisabet, Thompson, Stephen, Spinks, Daniel, Thomas, Michael, Sandberg, Lars, Francisco, Amanda F, Jayawardhana, Shiromani, Smith, Victoria C, Jansen, Chimed, De Rycker, Manu, Thomas, John, MacLean, Lorna, Osuna-Cabello, Maria, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C, Epemolu, Ola, Shishikura, Yoko, Crouch, Sabrinia D, Bakshi, Tania S, Nixon, Christopher J, Reid, Iain H, Hill, Alan P, Underwood, Tim Z, Hindley, Sean J, Robinson, Sharon A, Kelly, John M, Fiandor, Jose M, Wyatt, Paul G, Marco, Maria, Miles, Timothy J, Read, Kevin D, Gilbert, Ian H

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Identification and Optimization of a Series of 8‑Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity von Thomas, Michael G, De Rycker, Manu, Wall, Richard J, Spinks, Daniel, Epemolu, Ola, Manthri, Sujatha, Norval, Suzanne, Osuna-Cabello, Maria, Patterson, Stephen, Riley, Jennifer, Simeons, Frederick R. C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Naylor, Claire, Fiandor, Jose M, Wyatt, Paul G, Marco, Maria, Wyllie, Susan, Read, Kevin D, Miles, Timothy J, Gilbert, Ian H

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Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series von Coterón, Jose M, Catterick, David, Castro, Julia, Chaparro, María J, Díaz, Beatriz, Fernández, Esther, Ferrer, Santiago, Gamo, Francisco J, Gordo, Mariola, Gut, Jiri, de las Heras, Laura, Legac, Jennifer, Marco, Maria, Miguel, Juan, Muñoz, Vicente, Porras, Esther, de la Rosa, Juan C, Ruiz, Jose R, Sandoval, Elena, Ventosa, Pilar, Rosenthal, Philip J, Fiandor, Jose M

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Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis von Armitage, Emily G, Godzien, Joanna, Peña, Imanol, López-Gonzálvez, Ángeles, Angulo, Santiago, Gradillas, Ana, Alonso-Herranz, Vanesa, Martín, Julio, Fiandor, Jose M, Barrett, Michael P, Gabarro, Raquel, Barbas, Coral

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Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials von Yeates, Clive L, Batchelor, John F, Capon, Edward C, Cheesman, Neil J, Fry, Mitch, Hudson, Alan T, Pudney, Mary, Trimming, Helen, Woolven, James, Bueno, José M, Chicharro, Jesús, Fernández, Esther, Fiandor, José M, Gargallo-Viola, Domingo, Gómez de las Heras, Federico, Herreros, Esperanza, León, María L

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Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection von Kavouris, John A, McCall, Laura-Isobel, Giardini, Miriam A, De Muylder, Geraldine, Thomas, Diane, Garcia-Pérez, Adolfo, Cantizani, Juan, Cotillo, Ignacio, Fiandor, Jose M, McKerrow, James H, De Oliveira, Camila I, Siqueira-Neto, Jair L, González, Silvia, Brown, Lauren E, Schaus, Scott E

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Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis von Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D., Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, Cesar, Mackenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F., Fiandor, Jose M., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Miles, Timothy J.

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Identification of 6-amino-1 H -pyrazolo[3,4- d ]pyrimidines with in vivo efficacy against visceral leishmaniasis von Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D, Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F, Fiandor, Jose M, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H, Miles, Timothy J

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Corrections to Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series von Coterón, Jose M, Catterick, David, Castro, Julia, Chaparro, María J, Díaz, Beatriz, Fernández, Esther, Ferrer, Santiago, Gamo, Francisco J, Gordo, Mariola, Gut, Jiri, de las Heras, Laura, Legac, Jennifer, Marco, Maria, Miguel, Juan, Muñoz, Vicente, Porras, Esther, de la Rosa, Juan C, Ruiz, Jose R, Sandoval, Elena, Ventosa, Pilar, Rosenthal, Philip J, Fiandor, Jose M

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Short-course combination treatment for experimental chronic Chagas disease von González, Silvia, Wall, Richard J, Thomas, John, Braillard, Stephanie, Brunori, Gino, Camino Díaz, Isabel, Cantizani, Juan, Carvalho, Sandra, Castañeda Casado, Pablo, Chatelain, Eric, Cotillo, Ignacio, Fiandor, Jose M, Francisco, Amanda Fortes, Grimsditch, David, Keenan, Martine, Kelly, John M, Kessler, Albane, Luise, Chiara, Lyon, Jon J, MacLean, Lorna, Marco, Maria, Martin, J Julio, Martinez Martinez, Maria S, Paterson, Christy, Read, Kevin D, Santos-Villarejo, Angel, Zuccotto, Fabio, Wyllie, Susan, Miles, Tim J, De Rycker, Manu

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Stereoselective synthesis of the antifungal GM222712 von Bueno, José M, Coterón, José M, Chiara, Jose Luis, Fernández-Mayoralas, Alfonso, Fiandor, José M, Valle, Nuria

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Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis von Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick, Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.

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