Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones von Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Thomas, Mark P., Hamel, Ernest, Ferrandis, Eric, Mahon, Mary F., Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

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Structure–Activity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents von Leese, Mathew P, Jourdan, Fabrice L, Gaukroger, Keira, Mahon, Mary F, Newman, Simon P, Foster, Paul A, Stengel, Chloe, Regis-Lydi, Sandra, Ferrandis, Eric, Fiore, Anna Di, De Simone, Giuseppina, Supuran, Claudiu T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure von Dohle, Wolfgang, Jourdan, Fabrice L, Menchon, Grégory, Prota, Andrea E, Foster, Paul A, Mannion, Pascoe, Hamel, Ernest, Thomas, Mark P, Kasprzyk, Philip G, Ferrandis, Eric, Steinmetz, Michel O, Leese, Mathew P, Potter, Barry V. L

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IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents von Liberatore, Anne-Marie, Coulomb, Hélène, Pons, Dominique, Dutruel, Olivier, Kasprzyk, Philip G, Carlson, Mark, Nelson, Ann Savola, Newman, Simon P, Stengel, Chloe, Auvray, Pierrïck, Hesry, Vincent, Foll, Béatrice, Narboux, Nadine, Morlais, Delphine, Le Moing, Mélissa, Bernetiere, Sonia, Dellile, Raphael, Camara, Jose, Ferrandis, Eric, Bigg, Dennis C, Prévost, Grégoire P

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Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on Gα Subunit von Ayoub, Mohammed Akli, Damian, Marjorie, Gespach, Christian, Ferrandis, Eric, Lavergne, Olivier, De Wever, Olivier, Banères, Jean-Louis, Pin, Jean-Philippe, Prévost, Grégoire Pierre

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Novel azoles as potent and selective cannabinoid CB2 receptor agonists von Harnett, Jeremiah J., Dolo, Christine, Viossat, Isabelle, Auger, Florence, Ferrandis, Eric, Bigg, Dennis, Auguet, Michel, Auvin, Serge, Chabrier, Pierre-E.

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Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate von Jourdan, Fabrice, Leese, Mathew P, Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Newman, Simon P, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Structure–Activity Relationships of C-17-Substituted Estratriene-3-O-sulfamates as Anticancer Agents von Jourdan, Fabrice, Leese, Mathew P, Dohle, Wolfgang, Ferrandis, Eric, Newman, Simon P, Chander, Surinder, Purohit, Atul, Potter, Barry V. L

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Optimisation of Tetrahydroisoquinoline-Based Chimeric Microtubule Disruptors von Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Chapman, Christopher J., Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.

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3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives:  Synthesis, In Vitro and In Vivo Anticancer Activity von Bubert, Christian, Leese, Mathew P, Mahon, Mary F, Ferrandis, Eric, Regis-Lydi, Sandra, Kasprzyk, Philip G, Newman, Simon P, Ho, Yaik T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors von Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

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Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines von Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Kasprzyk, Philip G., Fiore, Ann, Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

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Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G alpha /G beta gamma Protein Complex von Prevost, Gregoire P, Lonchampt, Marie O, Holbeck, Susan, Attoub, Samir, Zaharevitz, Daniel, Alley, Mike, Wright, John, Brezak, Marie C, Coulomb, Helene, Savola, Ann, Huchet, Marion, Chaumeron, Sophie, Nguyen, Quang-De, gez, Patricia, Bruyneel, Erik, Bracke, Mark, Ferrandis, Eric, Roubert, Pierre, Demarquay, Daniele, Gespach, Christian, Kasprzyk, Philip G

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Chimeric microtubule disruptors von Leese, Mathew P, Jourdan, Fabrice, Kimberley, Meriel R, Cozier, Gyles E, Thiyagarajan, Nethaji, Stengel, Chloe, Regis-Lydi, Sandra, Foster, Paul A, Newman, Simon P, Acharya, K Ravi, Ferrandis, Eric, Purohit, Atul, Reed, Michael J, Potter, Barry V L

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BN82451 attenuates l-dopa-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson’s disease von Spinnewyn, Brigitte, Mautino, Gisele, Marin, Jean-Gregoire, Rocher, Marie Noëlle, Grandoulier, Anne Sophie, Ferrandis, Eric, Auguet, Michel, Chabrier, Pierre-Etienne

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Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Gα/Gβγ protein complex von PREVOST, Grégoire P, LONCHAMPT, Marie O, HUCHET, Marion, CHAUMERON, Sophie, NGUYEN, Quang-Dé, FORGEZ, Patricia, BRUYNEEL, Erik, BRACKE, Mark, FERRANDIS, Eric, ROUBERT, Pierre, DEMARQUAY, Danièle, GESPACH, Christian, HOLBECK, Susan, KASPRZYK, Philip G, ATTOUB, Samir, ZAHAREVITZ, Daniel, ALLEY, Mike, WRIGHT, John, BREZAK, Marie C, COULOMB, Hélène, SAVOLA, Ann

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Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: Templates for design von Allan, Gillian M., Vicker, Nigel, Lawrence, Harshani R., Tutill, Helena J., Day, Joanna M., Huchet, Marion, Ferrandis, Eric, Reed, Michael J., Purohit, Atul, Potter, Barry V.L.

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Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors von Leese, Mathew P, Jourdan, Fabrice, Dohle, Wolfgang, Kimberley, Meriel R, Thomas, Mark P, Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L

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Cover Picture: Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014) von Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

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A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist von Ross, Richard J, Wilkinson, Ian R, Ferrandis, Eric, Artymiuk, Peter J, Teillot, Marc, Soulard, Chantal, Touvay, Caroline, Pradhananga, Sarbendra L, Justice, Sue, Wu, Zida, Leung, Kin C, Strasburger, Christian J, Sayers, Jon R

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