Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor von FENWICK, Craig, AMAD, Ma'an, FADER, Lee D, FAUCHER, Anne-Marie, GARNEAU, Michel, JAKALIAN, Araz, KAWAI, Stephen, LAMORTE, Louie, LAPLANTE, Steven, LAIBIN LUO, MASON, Steve, POUPART, Marc-André, BAILEY, Murray D, RIOUX, Nathalie, SCHROEDER, Patricia, SIMONEAU, Bruno, TREMBLAY, Sonia, TSANTRIZOS, Youla, WITVROUW, Myriam, YOAKIM, Christiane, BETHELL, Richard, BÖS, Michael, BONNEAU, Pierre, CORDINGLEY, Michael, COULOMBE, René, DUAN, Jianmin, EDWARDS, Paul

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Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein von LEMKE, Christopher T, TITOLO, Steve, GAGNON, Alexandre, KAWAI, Stephen H, RANCOURT, Jean, TREMBLAY, Martin, YOAKIM, Christiane, SIMONEAU, Bruno, ARCHAMBAULT, Jacques, SUNDQUIST, Wesley I, MASON, Stephen W, VON SCHWEDLER, Uta, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, FAUCHER, Anne-Marie, COULOMBE, Rene, BANIK, Soma S. R, FADER, Lee

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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1 von Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla

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A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization von Lemke, Christopher T., Titolo, Steve, Goudreau, Nathalie, Faucher, Anne-Marie, Mason, Stephen W., Bonneau, Pierre

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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly von Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane

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Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target von VAILLANCOURT, Frederic H, BRAULT, Martine, CHIU, Tim T, MAHROUCHE, Louiza, FAUCHER, Anne-Marie, CARTIER, Mireille, CORDINGLEY, Michael G, BETHELL, Richard C, HUIPING JIANG, WHITE, Peter W, KUKOLJ, George, PILOTE, Louise, UYTTERSPROT, Nathalie, GAILLARD, Elias T, STOTTZ, James H, KNIGHT, Brian L, PANTAGES, Lynn, MCFARIAND, Mary, BREITFELDER, Steffen

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Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase von Faucher, Anne-Marie, White, Peter W, Brochu, Christian, Grand-Maître, Chantal, Rancourt, Jean, Fazal, Gulrez

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First Archaeological Evidence for Old World Crops in the Caribbean: The Presence of Barley on the Island of Barbuda von Faucher, Anne-Marie, Bain, Allison, Grimes, Vaughan

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Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibi... von Goudreau, Nathalie, Hucke, Oliver, Faucher, Anne-Marie, Grand-Maître, Chantal, Lepage, Olivier, Bonneau, Pierre R., Mason, Stephen W., Titolo, Steve

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus von Lamarre, Daniel, Anderson, Paul C, Bailey, Murray, Beaulieu, Pierre, Bolger, Gordon, Bonneau, Pierre, Bös, Michael, Cameron, Dale R, Cartier, Mireille, Cordingley, Michael G, Faucher, Anne-Marie, Goudreau, Nathalie, Kawai, Stephen H, Kukolj, George, Lagacé, Lisette, LaPlante, Steven R, Narjes, Hans, Poupart, Marc-André, Rancourt, Jean, Sentjens, Roel E, St George, Roger, Simoneau, Bruno, Steinmann, Gerhard, Thibeault, Diane, Tsantrizos, Youla S, Weldon, Steven M, Yong, Chan-Loi, Llinàs-Brunet, Montse

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Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486 von WHITE, Peter W, FAUCHER, Anne-Marie, MASSARIOL, Marie-Josée, WELCHNER, Ewald, RANCOURT, Jean, CARTIER, Mireille, ARCHAMBAULT, Jacques

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Novel Inhibitor Binding Site Discovery on HIV‑1 Capsid N‑Terminal Domain by NMR and X‑ray Crystallography von Goudreau, Nathalie, Lemke, Christopher T, Faucher, Anne-Marie, Grand-Maître, Chantal, Goulet, Sylvie, Lacoste, Jean-Eric, Rancourt, Jean, Malenfant, Eric, Mercier, Jean-François, Titolo, Steve, Mason, Stephen W

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Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1 von JIANMIN DUAN, LIUZZI, Michel, PARIS, William, LIARD, Francine, BROWNE, Abigail, DANSEREAU, Nathalie, SIMONEAU, Bruno, FAUCHER, Anne-Marie, CORDINGLEY, Michael G

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Preparation of Chiral Bisoxazolines: Observations on the Effect of Substituents von Denmark, Scott E, Nakajima, Noriyuki, Nicaise, Olivier J.-C, Faucher, Anne-Marie, Edwards, James P

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Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease von Crute, James J, Grygon, Christine A, Hargrave, Karl D, Simoneau, Bruno, Faucher, Anne-Marie, Bolger, Gordon, Kibler, Philip, Liuzzi, Michel, Cordingley, Michael G

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Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061 von Llinàs-Brunet, Montse, Bailey, Murray D, Bolger, Gordon, Brochu, Christian, Faucher, Anne-Marie, Ferland, Jean Marie, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Grand-Maître, Chantal, Halmos, Ted, Lapeyre-Paquette, Nicole, Liard, Francine, Poirier, Martin, Rhéaume, Manon, Tsantrizos, Youla S, Lamarre, Daniel

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Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors von O’Meara, Jeff A., Jakalian, Araz, LaPlante, Steven, Bonneau, Pierre R., Coulombe, René, Faucher, Anne-Marie, Guse, Ingrid, Landry, Serge, Racine, Jennifer, Simoneau, Bruno, Thavonekham, Bounkham, Yoakim, Christiane

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Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans von Faucher, Anne-Marie, Bailey, Murray D, Beaulieu, Pierre L, Brochu, Christian, Duceppe, Jean-Simon, Ferland, Jean-Marie, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Kawai, Stephen H, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S, Llinàs-Brunet, Montse

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Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors von Tremblay, Martin, Bethell, Richard C., Cordingley, Michael G., DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Edwards, Paul J., Faucher, Anne-Marie, Halmos, Ted, James, Clint A., Kuhn, Cyrille, Lacoste, Jean-Éric, Lamorte, Louie, LaPlante, Steven R., Malenfant, Éric, Minville, Joannie, Morency, Louis, Morin, Sébastien, Rajotte, Daniel, Salois, Patrick, Simoneau, Bruno, Tremblay, Sonia, Sturino, Claudio F.

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Cyclopropanation with Diazomethane and Bis(oxazoline)palladium(II) Complexes von Denmark, Scott E, Stavenger, Robert A, Faucher, Anne-Marie, Edwards, James P

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