Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice von JIMENEZ-CHILLARON, Josep C, ISGANAITIS, Elvira, PATTI, Mary-Elizabeth, CHARALAMBOUS, Marika, GESTA, Stephane, PENTINAT-PELEGRIN, Thais, FAUCETTE, Ryan R, OTIS, Jessica P, CHOW, Alice, DIAZ, Ruben, FERGUSON-SMITH, Anne

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Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody von Kenniston, Jon A., Faucette, Ryan R., Martik, Diana, Comeau, Stephen R., Lindberg, Allison P., Kopacz, Kris J., Conley, Gregory P., Chen, Jie, Viswanathan, Malini, Kastrapeli, Niksa, Cosic, Janja, Mason, Shauna, DiLeo, Mike, Abendroth, Jan, Kuzmic, Petr, Ladner, Robert C., Edwards, Thomas E., TenHoor, Christopher, Adelman, Burt A., Nixon, Andrew E., Sexton, Daniel J.

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Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015 von Dagbay, Kevin B., Treece, Erin, Streich, Frederick C., Jackson, Justin W., Faucette, Ryan R., Nikiforov, Anastasia, Lin, Susan C., Boston, Chris J., Nicholls, Samantha B., Capili, Allan D., Carven, Gregory J.

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2D-LC-MS/MS to measure cleaved high-molecular-weight kininogen in human plasma as a biomarker for C1-INH-HAE von Zhang, Guodong, Sexton, Daniel J, Faucette, Ryan R, Qiu, Yongchang, Wu, Jiang

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Nonclinical Development of SRK-181: An Anti-Latent TGFβ1 Monoclonal Antibody for the Treatment of Locally Advanced or Metastatic Solid Tumors von Welsh, Brian T., Faucette, Ryan, Bilic, Sanela, Martin, Constance J., Schürpf, Thomas, Chen, David, Nicholls, Samantha, Lansita, Janice, Kalra, Ashish

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A phase 1 study investigating DX-2930 in healthy subjects von Chyung, Yung, MD, Vince, Bradley, DO, Iarrobino, Ryan, BA, Sexton, Dan, PhD, Kenniston, Jon, PhD, Faucette, Ryan, BS, TenHoor, Chris, PharmD, PhD, Stolz, Leslie E., PhD, Stevens, Chris, MD, Biedenkapp, Joseph, PhD, Adelman, Burt, MD

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A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema von Sexton, Dan, Faucette, Ryan, Rivera-Hernandez, Melody, Kenniston, Jon A, Papaioannou, Nikolaos, Cosic, Janja, Kopacz, Kris, Salmon, Gary, Beauchemin, Chantal, Juethner, Salomé, Yeung, Dave

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Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis von Banerji, Aleena, Busse, Paula, Shennak, Mustafa, Lumry, William, Davis-Lorton, Mark, Wedner, Henry J, Jacobs, Joshua, Baker, James, Bernstein, Jonathan A, Lockey, Richard, Li, H. Henry, Craig, Timothy, Cicardi, Marco, Riedl, Marc, Al-Ghazawi, Ahmad, Soo, Carolyn, Iarrobino, Ryan, Sexton, Daniel J, TenHoor, Christopher, Kenniston, Jon A, Faucette, Ryan, Still, J. Gordon, Kushner, Harvey, Mensah, Robert, Stevens, Chris, Biedenkapp, Joseph C, Chyung, Yung, Adelman, Burt

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Abstract 1801: Development of a comprehensive biomarker strategy to support phase 1 clinical trial of SRK-181 the latent TGFβ1 inhibitor von Brueckner, Christopher, Faucette, Ryan, Caldwell, Charles, Reitsma, Sofia, Wawersik, Stefan, Kalra, Ashish, Gan, Lu, Lee-Hoeflich, Si Tuen

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First-in-human phase 1 trial (DRAGON) of SRK-181, a potential first-in-class selective latent TGFβ1 inhibitor, alone or in combination with anti-PD-(L)1 treatment in patients with... von Yap, Timothy A., Barve, Minal A., Gainor, Justin F., Weekes, Colin D., Bockorny, Bruno, Ju, Yawen, Faucette, Ryan, Bilic, Sanela, Lee-Hoeflich, Si Tuen, Song, Guochen, Chyung, Yung, Legler, Michelle, Gan, Lu, Bendell, Johanna C.

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Peroxisome Proliferator Activator Receptor γ Coactivator-1 Expression Is Reduced in Obesity: POTENTIAL PATHOGENIC ROLE OF SATURATED FATTY ACIDS AND p38 MITOGEN-ACTIVATED PROTEIN KI... von Crunkhorn, Sarah, Dearie, Farrell, Mantzoros, Christos, Gami, Hiral, da Silva, Wagner S, Espinoza, Daniel, Faucette, Ryan, Barry, Kristen, Bianco, Antonio C, Patti, Mary Elizabeth

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A Biomarker Assay For The Detection Of Contact System Activation von Faucette, Ryan R, Cicardi, Marco, Suffritti, Chiara, Kenniston, Jon A, Sexton, Daniel J, Adelman, Burt

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Comparison Of Plasma Kallikrein Inhibition By The Monoclonal Antibody Inhibitor DX-2930 To Endogenous C1-INH von Sexton, Daniel, Kenniston, Jon, Faucette, Ryan, Nixon, Andrew, TenHoor, Christopher, Chyung, Yung H, Adelman, Burt

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Comparison Of Plasma Kallikrein Inhibition By The Endogenous C1-Inhibitor Versus DX-2930, a Monoclonal Antibody Inhibitor von Sexton, Daniel J, Kenniston, Jon A, Faucette, Ryan R, Nixon, Andrew E, TenHoor, Chris, Chyung, Yung, Adelman, Burt

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Discovery and Characterization of a Highly Specific Antibody Inhibitor of Factor XIIa, and the Subsequent Generation of a Factor XIIa/Plasma Kallikrein Bispecific Antibody von Mason, Shauna D, Kenniston, Jon, Comeau, Stephen R, Conley, Gregory P, Kastrapeli, Niksa, Kopacz, Kris J, Lindberg, Allison P, Cosic, Janja, Kivaa, Monicah, Qiu, James A, Faucette, Ryan, Sexton, Dan, Tenhoor, Christopher, Gailani, David, Dickeson, S. Kent, Cheng, Qiufang, Wallisch, Michael, Gruber, Andras, Adelman, Burt, Nixon, Andrew

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Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015 von Dagbay, Kevin B, Treece, Erin, Streich, Jr, Frederick C, Jackson, Justin W, Faucette, Ryan R, Nikiforov, Anastasia, Lin, Susan C, Boston, Chris J, Nicholls, Samantha B, Capili, Allan D, Carven, Gregory J

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Refined Method for Collection of Plasma Samples to Evaluate the Role of Plasma Kallikrein in Various Disease States von Bernstein, Jonathan A., MD, Wedner, H. James, MD FAAAAI, Busse, Paula J., MD FAAAAI, Banerji, Aleena, MD, Cicardi, Marco, Sufritti, C, Brooks, Edward G., MD, Cheifitz, Adam, Schwartz, Lawrence B., MD PhD FAAAAI, Akin, Cem, MD PhD FAAAAI, Sexton, Daniel, Stevens, Chris, Stolz, Leslie E, Viswanathan, Malini, Faucette, Ryan, Biedenkapp, Joseph C, Chyung, Yung H, Adelman, Burt

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Modeling and Analyses to Identify Potential Dosing Regimens of DX-2930 for the Long-Term Prophylaxis of Hereditary Angioedema von Wedner, H. James, MD FAAAAI, Busse, Paula J., MD FAAAAI, Banerji, Aleena, MD, Shennak, Mustafa, Lumry, William R., MD FAAAAI, Davis-Lorton, Mark A., MD FAAAAI, Jacobs, Joshua S., MD, Baker, James W., MD FAAAAI, Bernstein, Jonathan A., MD, Lockey, Richard F., MD, Li, H. Henry, MD PhD, Craig, Timothy J, Cicardi, Marco, Riedl, Marc A., MD MS, Al-Ghazawi, Ahmad, Soo, Carolyn, Iarrobino, Ryan, Sexton, Daniel, TenHoor, Christopher, Faucette, Ryan, Biedenkapp, Joseph C, Chyung, Yung H, Adelman, Burt

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Relationship Between Drug Exposure and Clinical Response Observed in the Phase 1b Study of DX-2930 in Subjects with Hereditary Angioedema von Jacobs, Joshua S., MD, Busse, Paula J., MD FAAAAI, Banerji, Aleena, MD, Shennak, Mustafa, Lumry, William R., MD FAAAAI, Davis-Lorton, Mark A., MD FAAAAI, Wedner, H. James, MD FAAAAI, Baker, James W., MD FAAAAI, Bernstein, Jonathan A., MD, Lockey, Richard F., MD, Li, H. Henry, MD PhD, Craig, Timothy J, Cicardi, Marco, Riedl, Marc A., MD MS, Al-Ghazawi, Ahmad, Soo, Carolyn, Iarrobino, Ryan, Sexton, Daniel, TenHoor, Christopher, Faucette, Ryan, Biedenkapp, Joseph C, Chyung, Yung H, Adelman, Burt

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Pharmacodynamic Effect of DX-2930 on Plasma Kallikrein in Hereditary Angioedema Patients von Davis-Lorton, Mark A., MD FAAAAI, Busse, Paula J., MD FAAAAI, Banerji, Aleena, MD, Shennak, Mustafa, Lumry, William R., MD FAAAAI, Wedner, H. James, MD FAAAAI, Jacobs, Joshua S., MD, Baker, James W., MD FAAAAI, Bernstein, Jonathan A., MD, Lockey, Richard F., MD, Li, H. Henry, MD PhD, Craig, Timothy J, Cicardi, Marco, Riedl, Marc A., MD MS, Al-Ghazawi, Ahmad, Soo, Carolyn, Iarrobino, Ryan, Sexton, Daniel, TenHoor, Christopher, Faucette, Ryan, Biedenkapp, Joseph C, Chyung, Yung H, Adelman, Burt

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