Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives von Galbiati, Andrea, Zana, Aureliano, Borsari, Chiara, Persico, Marco, Bova, Stefania, Tkachuk, Oleh, Corfu, Alexandra Ioana, Tamborini, Lucia, Basilico, Nicoletta, Fattorusso, Caterina, Bruno, Stefano, Parapini, Silvia, Conti, Paola

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Tetrasubstituted Pyrrole Derivative Mimetics of Protein-Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells von Persico, Marco, Galatello, Paola, Ferraro, Maria Grazia, Irace, Carlo, Piccolo, Marialuisa, Abduvakhidov, Avazbek, Tkachuk, Oleh, d'Aulisio Garigliota, Maria Luisa, Campiglia, Pietro, Iannece, Patrizia, Varra, Michela, Ramunno, Anna, Fattorusso, Caterina

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Antiplasmodial Activity of p -Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections von Casertano, Marcello, Menna, Marialuisa, Fattorusso, Caterina, Basilico, Nicoletta, Parapini, Silvia, Persico, Marco, Imperatore, Concetta

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Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone von Imperatore, Concetta, Gimmelli, Roberto, Persico, Marco, Casertano, Marcello, Guidi, Alessandra, Saccoccia, Fulvio, Ruberti, Giovina, Luciano, Paolo, Aiello, Anna, Parapini, Silvia, Avunduk, Sibel, Basilico, Nicoletta, Fattorusso, Caterina, Menna, Marialuisa

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Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77 von FERLINI, Cristiano, CICCHILLITTI, Lucia, CAMPIANI, Giuseppe, SCAMBIA, Giovanni, RASPAGLIO, Giuseppina, BARTOLLINO, Silvia, CIMITAN, Samanta, BERTUCCI, Carlo, MOZZETTI, Simona, GALLO, Daniela, PERSICO, Marco, FATTORUSSO, Caterina

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Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells von Proto, Maria Chiara, Fiore, Donatella, Forte, Giovanni, Cuozzo, Paola, Ramunno, Anna, Fattorusso, Caterina, Gazzerro, Patrizia, Pascale, Maria, Franceschelli, Silvia

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Investigating the Role of T7 and T12 Residues on the Biological Properties of Thrombin-Binding Aptamer: Enhancement of Anticoagulant Activity by a Single Nucleobase Modification von Borbone, Nicola, Bucci, Mariarosaria, Oliviero, Giorgia, Morelli, Elena, Amato, Jussara, D’Atri, Valentina, D’Errico, Stefano, Vellecco, Valentina, Cirino, Giuseppe, Piccialli, Gennaro, Fattorusso, Caterina, Varra, Michela, Mayol, Luciano, Persico, Marco, Scuotto, Maria

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The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design von Tundo, Grazia Raffaella, Grasso, Giuseppe, Persico, Marco, Tkachuk, Oleh, Bellia, Francesco, Bocedi, Alessio, Marini, Stefano, Parravano, Mariacristina, Graziani, Grazia, Fattorusso, Caterina, Sbardella, Diego

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Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution von Persico, Marco, Santoro, Anna Maria, D’Urso, Alessandro, Milardi, Danilo, Purrello, Roberto, Cunsolo, Alessandra, Gobbo, Marina, Fattorusso, Roberto, Diana, Donatella, Stefanelli, Manuela, Tundo, Grazia R., Sbardella, Diego, Coletta, Massimo, Fattorusso, Caterina

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Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging von D'Urso, Alessandro, Purrello, Roberto, Cunsolo, Alessandra, Milardi, Danilo, Fattorusso, Caterina, Persico, Marco, Gaczynska, Maria, Osmulski, Pawel A, Santoro, Anna Maria

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Oxime Amides as a Novel Zinc Binding Group in Histone Deacetylase Inhibitors: Synthesis, Biological Activity, and Computational Evaluation von Botta, Cinzia B, Cabri, Walter, Cini, Elena, De Cesare, Lucia, Fattorusso, Caterina, Giannini, Giuseppe, Persico, Marco, Petrella, Antonello, Rondinelli, Francesca, Rodriquez, Manuela, Russo, Adele, Taddei, Maurizio

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Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones von Imperatore, Concetta, Cimino, Paola, Cebrián-Torrejón, Gerardo, Persico, Marco, Aiello, Anna, Senese, Maria, Fattorusso, Caterina, Menna, Marialuisa, Doménech-Carbó, Antonio

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Manadoperoxides A−D from the Indonesian Sponge Plakortis cfr. simplex. Further Insights on the Structure−Activity Relationships of Simple 1,2-Dioxane Antimalarials von Fattorusso, Caterina, Persico, Marco, Calcinai, Barbara, Cerrano, Carlo, Parapini, Silvia, Taramelli, Donatella, Novellino, Ettore, Romano, Adriana, Scala, Fernando, Fattorusso, Ernesto, Taglialatela-Scafati, Orazio

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Amygdaloidins A–L, twelve new 13 α-OH jatrophane diterpenes from Euphorbia amygdaloides L von Corea, Gabriella, Fattorusso, Caterina, Fattorusso, Ernesto, Lanzotti, Virginia

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Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells von Galbiati, Andrea, Bova, Stefania, Pacchiana, Raffaella, Borsari, Chiara, Persico, Marco, Zana, Aureliano, Bruno, Stefano, Donadelli, Massimo, Fattorusso, Caterina, Conti, Paola

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Specific Targeting of Acetylcholinesterase and Butyrylcholinesterase Recognition Sites. Rational Design of Novel, Selective, and Highly Potent Cholinesterase Inhibitors von Savini, Luisa, Gaeta, Alessandra, Fattorusso, Caterina, Catalanotti, Bruno, Campiani, Giuseppe, Chiasserini, Luisa, Pellerano, Cesare, Novellino, Ettore, McKissic, Dawn, Saxena, Ashima

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Artarborol, a nor-Caryophyllane Sesquiterpene Alcohol from Artemisia arborescens . Stereostructure Assignment through Concurrence of NMR Data and Computational Analysis von Fattorusso, Caterina, Stendardo, Emiliano, Appendino, Giovanni, Fattorusso, Ernesto, Luciano, Paolo, Romano, Adriana, Taglialatela-Scafati, Orazio

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A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action von Persico, Marco, Sessa, Raffaele, Cesaro, Elena, Dini, Irene, Costanzo, Paola, Ritieni, Alberto, Fattorusso, Caterina, Grosso, Michela

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Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, and Biological and Structure–Activity Relationship Studies von Gemma, Sandra, Campiani, Giuseppe, Butini, Stefania, Kukreja, Gagan, Coccone, Salvatore Sanna, Joshi, Bhupendra P, Persico, Marco, Nacci, Vito, Fiorini, Isabella, Novellino, Ettore, Fattorusso, Ernesto, Taglialatela-Scafati, Orazio, Savini, Luisa, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia, Morace, Giulia, Yardley, Vanessa, Croft, Simon, Coletta, Massimiliano, Marini, Stefano, Fattorusso, Caterina

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Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold:  Exploring an Innovative Pharmacophore von Gemma, Sandra, Campiani, Giuseppe, Butini, Stefania, Kukreja, Gagan, Joshi, Bhupendra P, Persico, Marco, Catalanotti, Bruno, Novellino, Ettore, Fattorusso, Ernesto, Nacci, Vito, Savini, Luisa, Taramelli, Donatella, Basilico, Nicoletta, Morace, Giulia, Yardley, Vanessa, Fattorusso, Caterina

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