Cytotoxic T Lymphocytes Kill Multiple Targets Simultaneously via Spatiotemporal Uncoupling of Lytic and Stimulatory Synapses von Wiedemann, Aurelie, Depoil, David, Faroudi, Mustapha, Valitutti, Salvatore

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Lytic versus Stimulatory Synapse in Cytotoxic T Lymphocyte/Target Cell Interaction: Manifestation of a Dual Activation Threshold von Faroudi, Mustapha, Utzny, Clemens, Salio, Mariolina, Cerundolo, Vincenzo, Guiraud, Martine, Müller, Sabina, Valitutti, Salvatore

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715 FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, induces LAG-3 shedding resulting in receptor downregulation by T cells via a novel mechanism of action von Morrow, Michelle, Faroudi, Mustapha, Chakraborty, Krishnendu, Liao, Wenjia, Winnewisser, Julia, Seal, Claire, Gliddon, Daniel, Brewis, Neil

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FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity von Kraman, Matthew, Faroudi, Mustapha, Allen, Natalie L, Kmiecik, Katarzyna, Gliddon, Daniel, Seal, Claire, Koers, Alexander, Wydro, Mateusz M, Batey, Sarah, Winnewisser, Julia, Young, Lesley, Tuna, Mihriban, Doody, Jacqueline, Morrow, Michelle, Brewis, Neil

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Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression von Sungalee, Stéphanie, Mamessier, Emilie, Morgado, Ester, Grégoire, Emilie, Brohawn, Philip Z, Morehouse, Christopher A, Jouve, Nathalie, Monvoisin, Céline, Menard, Cédric, Debroas, Guilhaume, Faroudi, Mustapha, Mechin, Violaine, Navarro, Jean-Marc, Drevet, Charlotte, Eberle, Franziska C, Chasson, Lionel, Baudimont, Fannie, Mancini, Stéphane J, Tellier, Julie, Picquenot, Jean-Michel, Kelly, Rachel, Vineis, Paolo, Ruminy, Philippe, Chetaille, Bruno, Jaffe, Elaine S, Schiff, Claudine, Hardwigsen, Jean, Tice, David A, Higgs, Brandon W, Tarte, Karin, Nadel, Bertrand, Roulland, Sandrine

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Abstract 5651: A LAG-3/PD-L1 bispecific antibody inhibits tumor growth in two syngeneic colon carcinoma models von Kraman, Matthew, Kmiecik, Katarzyna, Zimarino, Carlo, Everett, Katy, Faroudi, Mustapha, Wydro, Mateusz, Doody, Jacqueline

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Abstract 2399: LAG-3/PD-L1 mAb2 can overcome PD-L1-mediated compensatory upregulation of LAG-3 induced by single-agent checkpoint blockade von Faroudi, Mustapha, Kraman, Matthew, Fosh, Natalie, Reader, Claire, Gliddon, Daniel, Seal, Claire, Lucas, Christa, Koers, Alexander, Wydro, Mateusz, Morrow, Michelle, Brewis, Neil

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Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitum... von Kraman, Matthew, Fosh, Natalie, Kmiecik, Katarzyna, Everett, Katy, Zimarino, Carlo, Faroudi, Mustapha, Wydro, Mateusz, Koers, Alexander, Young, Lesley, Gliddon, Daniel, Morrow, Michelle, Doody, Jacqueline, Tuna, Mihriban, Brewis, Neil

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Critical roles for Rac GTPases in T-cell migration to and within lymph nodes von Faroudi, Mustapha, Hons, Miroslav, Zachacz, Agnieszka, Dumont, Celine, Lyck, Ruth, Stein, Jens V., Tybulewicz, Victor L.J.

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Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation von Caramalho, Íris, Faroudi, Mustapha, Padovan, Elisabetta, Müller, Sabina, Valitutti, Salvatore

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Mechanism and function of Vav1 localisation in TCR signalling von Ksionda, Olga, Saveliev, Alexander, Köchl, Robert, Rapley, Jonathan, Faroudi, Mustapha, Smith-Garvin, Jennifer E, Wülfing, Christoph, Rittinger, Katrin, Carter, Tom, Tybulewicz, Victor L J

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Abstract PR06: A LAG-3/PD-L1 bispecific antibody inhibits tumour growth in two syngeneic colon carcinoma models von Everett, Katy, Kraman, Matthew, Kmiecik, Katarzyna, Allen, Natalie, Faroudi, Mustapha, Zimarino, Carlo, Wydro, Mateusz, Doody, Jacqueline

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Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling von Faroudi, Mustapha, Zaru, Rossana, Paulet, Pierre, Muller, Sabina, Valitutti, Salvatore

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New insights to the functional role of the T cell-antigen presenting cell immunological synapse von Faroudi, Mustapha, Zaru, Rossana, Favier, Benoit, Valitutti, Salvatore

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Abstract B091: A LAG-3/PD-L1 bispecific antibody inhibits tumor growth in two syngeneic colon carcinoma models von Doody, Jacqueline, Kraman, Matthew, Everett, Katy, Zimarino, Carlo, Kmiecik, Katarzyna, Faroudi, Mustapha, Thompson, Paul, Wydro, Mateusz, Wollerton, Francisca, Gaspar, Carlos, Tuna, Mihriban

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Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression von Sungalee, Stéphanie, Mamessier, Emilie, Morgado, Ester, Grégoire, Emilie, Brohawn, Philip, Morehouse, Christopher, Jouve, Nathalie, Monvoisin, Céline, Menard, Cédric, Debroas, Guilhaume, Faroudi, Mustapha, Mechin, Violaine, Navarro, Jean-Marc, Drevet, Charlotte, Eberle, Franziska, Chasson, Lionel, Baudimont, Fannie, Mancini, Stéphane, Tellier, Julie, Picquenot, Jean-Michel, Kelly, Rachel, Vineis, Paolo, Ruminy, Philippe, Chetaille, Bruno, Jaffe, Elaine, Schiff, Claudine, Hardwigsen, Jean, Tice, David, Higgs, Brandon, Tarte, Karin, Nadel, Bertrand, Roulland, Sandrine

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Frequency Encoding of T-Cell Receptor Engagement Dynamics in Calcium Time Series von Utzny, Clemens, Faroudi, Mustapha, Valitutti, Salvatore

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The β1 and β3 Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation von Doucey, Marie-Agnès, Legler, Daniel F., Faroudi, Mustapha, Boucheron, Nicole, Baumgaertner, Petra, Naeher, Dieter, Cebecauer, Marek, Hudrisier, Denis, Rüegg, Curzio, Palmer, Ed, Valitutti, Salvatore, Bron, Claude, Luescher, Immanuel F.

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FC BINDING FRAGMENTS COMPRISING A PD-L1 ANTIGEN-BINDING SITE von Wollerton Van Horck, Francisca, Tuna, Mihriban, Akele, Frederick, Faroudi, Mustapha, Privezentzev, Cyril, Fiehler, Ryan, Badr, Fadi

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MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS von SAITAKIS, MICHAEL, AMIGORENA, SEBASTIAN, LANTZ, OLIVIER, GUILLOT-DELOST, MAUDE, FAROUDI, MUSTAPHA, GERARD, PIERRE-EMMANUEL, ZHUKOVSKY, EUGENE

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