Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2 von Clark, Michael P, Ledeboer, Mark W, Davies, Ioana, Byrn, Randal A, Jones, Steven M, Perola, Emanuele, Tsai, Alice, Jacobs, Marc, Nti-Addae, Kwame, Bandarage, Upul K, Boyd, Michael J, Bethiel, Randy S, Court, John J, Deng, Hongbo, Duffy, John P, Dorsch, Warren A, Farmer, Luc J, Gao, Huai, Gu, Wenxin, Jackson, Katrina, Jacobs, Dylan H, Kennedy, Joseph M, Ledford, Brian, Liang, Jianglin, Maltais, François, Murcko, Mark, Wang, Tiansheng, Wannamaker, M. Woods, Bennett, Hamilton B, Leeman, Joshua R, McNeil, Colleen, Taylor, William P, Memmott, Christine, Jiang, Min, Rijnbrand, Rene, Bral, Christopher, Germann, Ursula, Nezami, Azin, Zhang, Yuegang, Salituro, Francesco G, Bennani, Youssef L, Charifson, Paul S

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Robust Strategy for Hit-to-Lead Discovery: NMR for SAR von Larda, Sacha T., Ayotte, Yann, Denk, Maria M., Coote, Paul, Heffron, Gregory, Bendahan, David, Shahout, Fatma, Girard, Nicolas, Iddir, Mustapha, Bouchard, Patricia, Bilodeau, Francois, Woo, Simon, Farmer, Luc J., LaPlante, Steven R.

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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases von Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J

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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines von Hamann, Lawrence G, Higuchi, Robert I, Zhi, Lin, Edwards, James P, Wang, Xiao-Ning, Marschke, Keith B, Kong, James W, Farmer, Luc J, Jones, Todd K

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Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2 von Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.

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Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK) von FARMER, Luc J, BEMIS, Guy, TER HAAR, Ernst, JIAN WANG, ZHAVERI, Darshana, SALITURO, Francesco G, BRITT, Shawn D, COCHRAN, John, CONNORS, Martin, HARRINGTON, Edmund M, HOOCK, Thomas, MARKLAND, William, NANTHAKUMAR, Suganthini, TASLIMI, Paul

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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants von Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A

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Synthesis and Biological Activity of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Cyclocymopol Monomethyl Ether von Hamann, Lawrence G, Farmer, Luc J, Johnson, Michael G, Bender, Steven L, Mais, Dale E, Wang, Ming-Wei, Crombie, Diane, Goldman, Mark E, Jones, Todd K

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Aza-retinoids as novel retinoid X receptor-specific agonists von Farmer, Luc J., Marron, Kristen S., Canan Koch, Stacie S., Hwang, C.K., Kallel, E Adam, Zhi, Lin, Nadzan, Alex M., Robertson, Dave W., Bennani, Youssef L.

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Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid von Farmer, Luc J., Zhi, Lin, Jeong, Susan, Lamph, William W., Osburn, Deborah L., Croston, Glenn, Flatten, Karen S., Heyman, Rich A., Nadzan, Alex M.

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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants von Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A

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Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization von Perni, Robert B., Pitlik, Janos, Britt, Shawn D., Court, John J., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Levin, Rhonda B., Lin, Chao, Lin, Kai, Moon, Young-Choon, Luong, Yu-Ping, O'Malley, Ethan T., Rao, B.Govinda, Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi

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Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants von Perni, Robert B., Britt, Shawn D., Court, John C., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Kim, Joseph L., Landro, James A., Levin, Rhonda B., Luong, Yu-Ping, O'Malley, Ethan T., Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C., Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi

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New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1 H)-pyrrolidino[3,2- g]quinolinone von Edwards, James P., West, Sarah J., Pooley, Charlotte L.F., Marschke, Keith B., Farmer, Luc J., Jones, Todd K.

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4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6- g]quinolines: Potent, nonsteroidal androgen receptor agonists von Higuchi, Robert I., Edwards, James P., Caferro, Thomas R., Ringgenberg, Josef D., Kong, James W., Hamann, Lawrence G., Arienti, Kristen L., Marschke, Keith B., Davis, Robert L., Farmer, Luc J., Jones, Todd K.

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METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION von BOYD, Michael, John, FARMER, Luc, J, CWYNAR, Valerie, Ann, MILLER, David, B., Jr

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Inhibitors of hepatitis C virus NS3.4A protease. Part 3: P2 proline variants von PERNI, Robert B, FARMER, Luc J, KAI LIN, LUONG, Yu-Ping, MAXWELL, John P, MURCKO, Mark A, PITLIK, Janos, GOVINDA RAO, B, SCHAIRER, Wayne C, TUNG, Roger D, VAN DRIE, John H, WILSON, Keith, COTTRELL, Kevin M, THOMSON, John A, COURT, John J, COURTNEY, Lawrence F, DEININGER, David D, GATES, Cynthia A, HARBESON, Scott L, KIM, Joseph L, CHAO LIN

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Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization von PERNI, Robert B, PITLIK, Janos, CHAO LIN, KAI LIN, MOON, Young-Choon, LUONG, Yu-Ping, O'MALLEY, Ethan T, GOVINDA RAO, B, THOMSON, John A, TUNG, Roger D, VAN DRIE, John H, YUNYI WEI, BRITT, Shawn D, COURT, John J, COURTNEY, Lawrence F, DEININGER, David D, FARMER, Luc J, GATES, Cynthia A, HARBESON, Scott L, LEVIN, Rhonda B

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Methods of preparing inhibitors of influenza viruses replication von Cwynar, Valerie Ann, Farmer, Luc J, Boyd, Michael John, Miller, Jr., David B

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Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines von Hamann, Lawrence G., Winn, David T., Pooley, Charlotte L.F., Tegley, Christopher M., West, Sarah J., Farmer, Luc.J., Zhi, Lin, Edwards, James P., Marschke, Keith B., Mais, Dale E., Goldman, Mark E., Jones, Todd K.

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