Species-Specific Metabolism of SGX523 by Aldehyde Oxidase and the Toxicological Implications von Diamond, Sharon, Boer, Jason, Maduskuie, Thomas P., Falahatpisheh, Nikoo, Li, Yu, Yeleswaram, Swamy

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The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies von Stubbs, Matthew C, Burn, Timothy C, Sparks, Richard, Maduskuie, Thomas, Diamond, Sharon, Rupar, Mark, Wen, Xiaoming, Volgina, Alla, Zolotarjova, Nina, Waeltz, Paul, Favata, Margaret, Jalluri, Ravi, Liu, Huiqing, Liu, Xuesong Mike, Li, Jun, Collins, Robert, Falahatpisheh, Nikoo, Polam, Padmaja, DiMatteo, Darlise, Feldman, Patricia, Dostalik, Valerie, Thekkat, Pramod, Gardiner, Christine, He, Xin, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Ruggeri, Bruce, Yeleswaram, Swamy, Xue, Chu-Biao, Yao, Wenqing, Combs, Andrew P, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip C C

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INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3‑Kinase Delta (PI3Kδ) von Yue, Eddy W, Li, Yun-Long, Douty, Brent, He, Chunhong, Mei, Song, Wayland, Brian, Maduskuie, Thomas, Falahatpisheh, Nikoo, Sparks, Richard B, Polam, Padmaja, Zhu, Wenyu, Glenn, Joseph, Feng, Hao, Zhang, Ke, Li, Yanlong, He, Xin, Katiyar, Kamna, Covington, Maryanne, Feldman, Patricia, Shin, Niu, Wang, Kathy He, Diamond, Sharon, Li, Yu, Koblish, Holly K, Hall, Leslie, Scherle, Peggy, Yeleswaram, Swamy, Xue, Chu-Biao, Metcalf, Brian, Combs, Andrew P, Yao, Wenqing

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Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies von Stubbs, Matthew C., Maduskuie, Thomas, Burn, Timothy, Diamond-Fosbenner, Sharon, Falahatpisheh, Nikoo, Volgina, Alla, Zolotarjova, Nina, Wen, Xiaoming, Feldman, Patricia, Rupar, Mark, Collins, Robert, Marando, Cindy, Ruggeri, Bruce, Covington, Maryanne, Liu, Xuesong Mike, Wynn, Richard, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Combs, Andrew P., Liu, Phillip C.

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Abstract 3525: The BET inhibitor INCB054329 is efficacious as a single agent or in combination with targeted agents in colorectal cancer models von Liu, Xuesong, Li, Jun, He, Xin, Stubbs, Matthew, Favata, Margaret, Wen, Xiaoming, Chang, Hong, Rumberger, Beth R., Li, Yanlong, Maduskuie, Thomas, Sparks, Richard, Falahatpisheh, Nikoo, Polam, Padmaja, Combs, Andrew P., Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip C.

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Abstract C103: The combination of PI3kδ-selective inhibition and immunomodulation shows efficacy in solid tumor models von Koblish, Holly K., Wang, Liang-Chuan, Hansbury, Michael, Zhang, Yue, Yang, Gengjie, Burn, Timothy, Waeltz, Paul, Rupar, Mark, Yue, Eddy, Douty, Brent, Maduskuie, Thomas, Falahatpisheh, Nikoo, Li, Yun-long, Combs, Andrew, Hollis, Gregory, Huber, Reid, Scherle, Peggy

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Novel Inhibition of Porcine Pepsin by a Substituted Piperidine von Marcinkeviciene, Jovita, Kopcho, Lisa M., Yang, Tao, Copeland, Robert A., Glass, Brian M., Combs, Andrew P., Falahatpisheh, Nikoo, Thompson, Lorin

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Abstract 691: Activity of the BET inhibitor INCB054329 in models of multiple myeloma von Stubbs, Matthew, Wen, Xiaoming, Dostalik, Valerie, O'Connor, Sybil, Caulder, Eian, Vogina, Alla, Maduskuie, Thomas, Sparks, Richard, Huang, Taisheng, Falahatpisheh, Nikoo, Polam, Padmaja, Xue, Chu-Biao, Liu, Xuesong M., Burn, Timothy, Vaddi, Kris, Combs, Andrew P., Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC

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Abstract 3523: Discovery of a novel BET inhibitor INCB054329 von Liu, Phillip CC, Liu, Xuesong Mike, Stubbs, Matthew C., Maduskuie, Thomas, Sparks, Richard, Zolotarjova, Nina, Li, Jun, Wen, Xiaoming, Favata, Margaret, Feldman, Patricia, Volgina, Alla, DiMatteo, Darlise, Collins, Robert, Falahatpisheh, Nikoo, Polam, Padmaja, Li, Yu, Covington, Maryanne, Diamond-Fosbenner, Sharon, Wynn, Richard, Burn, Timothy, Vaddi, Kris, Yeleswaram, Swamy, Combs, Andrew P., Yao, Wenqing, Huber, Reid, Scherle, Peggy, Hollis, Gregory

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Abstract 692: The BET inhibitor INCB054329 is synergistic with JAK1 inhibition in models of multiple myeloma von Stubbs, Matthew C., Liu, Xuesong M., Wen, Xiaoming, Li, Jun, Dostalik, Valerie, O'Connor, Sybil, Caulder, Eian, Favata, Margaret, Rupar, Mark, Li, Yu, Rumberger, Beth, Maduskuie, Thomas, Sparks, Richard, Falahatpisheh, Nikoo, Polam, Padmaja, Vaddi, Kris, Burn, Timothy, Combs, Andrew P., Yao, Wenqing, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC

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Preparation of Glycosyl Tetrazoles and Application as Glycosyl Donors von Falahatpisheh, Nikoo, Sulikowski, Gary A.

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Photochemically Enhanced Binding of Small Molecules to the Tumor Necrosis Factor Receptor-1 Inhibits the Binding of TNF-α von Carter, Percy H., Scherle, Peggy A., Muckelbauer, Jodi A., Voss, Matthew E., Liu, Rui-Qin, Thompson, Lorin A., Tebben, Andrew J., Solomon, Kimberly A., Lo, Yvonne C., Li, Zhong, Strzemienski, Paul, Yang, Gengjie, Falahatpisheh, Nikoo, Xu, Meizhong, Wu, Zhongren, Farrow, Neil A., Ramnarayan, Kal, Wang, Jing, Rideout, Darryl, Yalamoori, Venkatachalapathi, Domaille, Peter, Underwood, Dennis J., Trzaskos, James M., Friedman, Steven M., Newton, Robert C., Decicco, Carl P.

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Pharmacological inactivation of PI3Kδ in the tumor microenvironment enhances efficacy of other immunotherapeutic agents von Wang, Liang-Chuan S, Koblish, Holly, Hansbury, Michael, Zhang, Yue, Yang, Gengjie, Burn, Timothy, Waeltz, Paul, Rupar, Mark, Yue, Eddy, Douty, Brent, Maduskuie, Thomas, Falahatpisheh, Nikoo, Li, Yun-Long, Combs, Andrew P, Hollis, Gregory, Huber, Reid, Scherle, Peggy

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1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS von COMBS, Andrew, MADUSKUIE, Thomas, FALAHATPISHEH, Nikoo

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1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins von Combs, Andrew, Maduskuie, Thomas, Falahatpisheh, Nikoo

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1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS von COMBS, Andrew, MADUSKUIE, Thomas, FALAHATPISHEH, Nikoo

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1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins von Combs, Andrew, Maduskuie, Thomas, Falahatpisheh, Nikoo

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1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins von Combs, Andrew, Maduskuie, Thomas, Falahatpisheh, Nikoo

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1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS von COMBS, Andrew, MADUSKUIE, Thomas, FALAHATPISHEH, Nikoo

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AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS von Shao, Lixin, Shepard, Stacey, Combs, Andrew P, Falahatpisheh, Nikoo

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