Allosteric inhibition of protein tyrosine phosphatase 1B von Wiesmann, Christian, Barr, Kenneth J, Kung, Jenny, Zhu, Jiang, Erlanson, Daniel A, Shen, Wang, Fahr, Bruce J, Zhong, Min, Taylor, Lisa, Randal, Mike, McDowell, Robert S, Hansen, Stig K

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Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development von Vu, Binh T., Dominique, Romyr, Fahr, Bruce J., Li, Hongju H., Fry, David C., Xu, Lizhong, Yang, Hong, Puzio-Kuter, Anna, Good, Andrew, Liu, Binbin, Huang, Kuo-Sen, Tanaka, Naoko, Davis, Thomas W., Dumble, Melissa L.

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Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering von Yang, Wenjin, Fucini, Raymond V, Fahr, Bruce T, Randal, Mike, Lind, Kenneth E, Lam, Melissa B, Lu, Wanli, Lu, Yafan, Cary, Douglas R, Romanowski, Michael J, Colussi, Dennis, Pietrak, Beth, Allison, Timothy J, Munshi, Sanjeev K, Penny, David M, Pham, Phuongly, Sun, Jian, Thomas, Anila E, Wilkinson, Jennifer M, Jacobs, Jeffrey W, McDowell, Robert S, Ballinger, Marcus D

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors von Fucini, Raymond V., Hanan, Emily J., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Barr, Kenneth J., Zhu, Jiang, Yoburn, Joshua C., Liu, Yang, Fahr, Bruce T., Fan, Junfa, Lu, Yafan, Pham, Phuongly, Choong, Ingrid C., VanderPorten, Erica C., Bui, Minna, Purkey, Hans E., Evanchik, Marc J., Yang, Wenjin

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MF-300 (15-PGDH ENZYME INHIBITOR) REVERSES AGE-RELATED MUSCLE WEAKNESS IN MICE BY RESTORING MUSCLE QUALITY von Webster, Micah, Martin, Jennifer, Fahr, Bruce, Khairallah, Ramzi

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Tethering identifies fragment that yields potent inhibitors of human caspase-1 von Fahr, Bruce T., O’Brien, Tom, Pham, Phuongly, Waal, Nathan D., Baskaran, Subramanian, Raimundo, Brian C., Lam, Joni W., Sopko, Michelle M., Purkey, Hans E., Romanowski, Michael J.

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Abstract LB006: PC14586: The first orally bioavailable small molecule reactivator of Y220C mutant p53 in clinical development von Dumble, Melissa, Xu, Lizhong, Dominique, Romyr, Liu, Binbin, Yang, Hong, McBrayer, Mary-Kate, Thomas, Dafydd, Fahr, Bruce, Li, Hongju, Huang, Kuo-Sen, Robell, Kimberly, Mulligan, Chris, Russo, Brandon, Puzio-Kuter, Anna, Davis, Thomas, Vu, Binh

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Total Synthesis of Aeruginosin 98B von Trost, Barry M, Kaneko, Toshiyuki, Andersen, Neil G, Tappertzhofen, Christoph, Fahr, Bruce

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PGDH INHIBITORS AND METHODS OF MAKING AND USING von FAHR, Bruce

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PGDH INHIBITORS AND METHODS OF MAKING AND USING von FAHR, Bruce

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Structural analysis of caspase-1 inhibitors derived from Tethering von Fahr, Bruce T., Sopko, Michelle M., Lam, Joni W., O'Brien, Tom, Waal, Nathan D., Pham, Phuongly, Purkey, Hans E., Raimundo, Brian C., Romanowski, Michael J.

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Novel Base-Induced [1,2]-Acyl Shift of Allylic Esters of Cyclopropanecarboxylic Acids von Jung, Michael E, Fahr, Bruce T

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Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency von Egbertson, Melissa, McGaughey, Georgia B., Pitzenberger, Steven M., Stauffer, Shaun R., Coburn, Craig A., Stachel, Shawn J., Yang, Wenjin, Barrow, James C., Neilson, Lou Anne, McWherter, Melody, Perlow, Debra, Fahr, Bruce, Munshi, Sanjeev, Allison, Timothy J., Holloway, Katharine, Selnick, Harold G., Yang, ZhiQiang, Swestock, John, Simon, Adam J., Sankaranarayanan, Sethu, Colussi, Dennis, Tugusheva, Katherine, Lai, Ming-Tain, Pietrak, Beth, Haugabook, Shari, Jin, Lixia, Chen, I.-W., Holahan, Marie, Stranieri-Michener, Maria, Cook, Jacquelynn J., Vacca, Joseph, Graham, Samuel L.

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Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design von Choong, Ingrid C, Lew, Willard, Lee, Dennis, Pham, Phuongly, Burdett, Matthew T, Lam, Joni W, Wiesmann, Christian, Luong, Tinh N, Fahr, Bruce, DeLano, Warren L, McDowell, Robert S, Allen, Darin A, Erlanson, Daniel A, Gordon, Eric M, O'Brien, Tom

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Total Syntheses of the Cytotoxic Marine Natural Product, Aplysiapyranoid C1 von Jung, Michael E, Fahr, Bruce T, D'Amico, Derin C

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METHODS FOR COMBINATION TREATMENT OF SPINAL MUSCULAR ATROPHY von CASDIN, Alexander, FAHR, Bruce, WEBSTER, Micah

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Modifications of the isonipecotic acid fragment of SNS-032 : Analogs with improved permeability and lower efflux ratio von JUNFA FAN, FAHR, Bruce, CHOONG, Ingrid C, STOCKETT, David, CHAN, Erica, CHEETI, Sravanthi, SERAFIMOVA, Iana, YAFAN LU, PHAM, Phuongly, WALKER, Duncan H, HOCH, Ute

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A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties von Choong, Ingrid C., Serafimova, Iana, Fan, Junfa, Stockett, David, Chan, Erica, Cheeti, Sravanthi, Lu, Yafan, Fahr, Bruce, Pham, Phuongly, Arkin, Michelle R., Walker, Duncan H., Hoch, Ute

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BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING von FAHR, Bruce, GREEN, Michael J, DUGAR, Sundeep, RAI, Roopa

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PYRROLO[2,3-B]PYRIDINE PGDH INHIBITORS AND METHODS OF MAKING AND USING von FAHR, Bruce, GREEN, Michael J, DUGAR, Sundeep, RAI, Roopa

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