New advances in CMV and immunosenescence von Sansoni, Paolo, Vescovini, Rosanna, Fagnoni, Francesco F., Akbar, Arne, Arens, Ramon, Chiu, Yen-Ling, Čičin-Šain, Luka, Dechanet-Merville, Julie, Derhovanessian, Evelyna, Ferrando-Martinez, Sara, Franceschi, Claudio, Frasca, Daniela, Fulöp, Tamas, Furman, David, Gkrania-Klotsas, Effrossyni, Goodrum, Felicia, Grubeck-Loebenstein, Beatrix, Hurme, Mikko, Kern, Florian, Lilleri, Daniele, López-Botet, Miguel, Maier, Andrea B., Marandu, Thomas, Marchant, Arnaud, Matheï, Catharina, Moss, Paul, Muntasell, Aura, Remmerswaal, Ester B.M., Riddell, Natalie E., Rothe, Kathrin, Sauce, Delphine, Shin, Eui-Cheol, Simanek, Amanda M., Smithey, Megan J., Söderberg-Nauclér, Cecilia, Solana, Rafael, Thomas, Paul G., van Lier, Rene, Pawelec, Graham, Nikolich-Zugich, Janko

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Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2 von VARCHETTA, Stefania, GIBELLI, Nadia, COSTA, Alberto, FAGNONI, Francesco F, OLIVIERO, Barbara, NARDINI, Elena, GENNARI, Roberto, GATTI, Giovanna, SANTOS SILVA, Luzemira, VILLANI, Laura, TAGLIABUE, Elda, MENARD, Sylvie

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The immune system in extreme longevity von Sansoni, P., Vescovini, R., Fagnoni, F., Biasini, C., Zanni, F., Zanlari, L., Telera, A., Lucchini, G., Passeri, G., Monti, D., Franceschi, C., Passeri, M.

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Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging von Fagnoni, Francesco F., Vescovini, Rosanna, Passeri, Giovanni, Bologna, Giovanni, Pedrazzoni, Mario, Lavagetto, Giampaolo, Casti, Amos, Franceschi, Claudio, Passeri, Mario, Sansoni, Paolo

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Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses von ZERBINI, Alessandro, PILLI, Massimo, MISSALE, Gabriele, PENNA, Amalia, PELOSI, Guido, SCHIANCHI, Claudia, MOLINARI, Atim, SCHIVAZAPPA, Simona, ZIBERA, Carlo, FAGNONI, Francesco F, FERRARI, Carlo

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Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8 + T cells von Vescovini, Rosanna, Telera, Annarita, Fagnoni, Francesco F, Biasini, Claudia, Medici, Maria Cristina, Valcavi, Pierpaolo, di Pede, Patricia, Lucchini, Gianluca, Zanlari, Luca, Passeri, Giovanni, Zanni, Franco, Chezzi, Carlo, Franceschi, Claudio, Sansoni, Paolo

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P155 BLOCKING OF NEGATIVE CO-STIMULATORY PATHWAYS CAN ENHANCE TUMOR-SPECIFIC T-CELL RESPONSE IN HCC PATIENTS UNDERGOING AN IMMUNOTHERAPEUTIC PROTOCOL BASED ON RADIOFREQUENCY THERMA... von Zerbini, A, Pilli, M, Olivani, A, Schianchi, C, Biasini, E, Canetti, D, Massari, M, Fagnoni, F, Ferrari, C, Missale, G

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor von GODFREY, W. R, FAGNONI, F. F, HARARA, M. A, BUCK, D, ENGLEMAN, E. G

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Expansion of cytotoxic CD8+ CD28− T cells in healthy ageing people, including centenarians von FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., SANSONI, P.

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Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic myeloablative hematopoietic stem cell transplantation von Fagnoni, Francesco F., Oliviero, Barbara, Giorgiani, Giovanna, De Stefano, Piero, Dehò, Anna, Zibera, Carlo, Gibelli, Nadia, Maccario, Rita, Da Prada, GianAntonio, Zecca, Marco, Locatelli, Franco

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Massive Load of Functional Effector CD4+ and CD8+ T Cells against Cytomegalovirus in Very Old Subjects von Vescovini, Rosanna, Biasini, Claudia, Fagnoni, Francesco F, Telera, Anna Rita, Zanlari, Luca, Pedrazzoni, Mario, Bucci, Laura, Monti, Daniela, Medici, Maria Cristina, Chezzi, Carlo, Franceschi, Claudio, Sansoni, Paolo

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Intense Antiextracellular Adaptive Immune Response to Human Cytomegalovirus in Very Old Subjects with Impaired Health and Cognitive and Functional Status von Vescovini, Rosanna, Biasini, Claudia, Telera, Anna Rita, Basaglia, Manuela, Stella, Adriano, Magalini, Francesca, Bucci, Laura, Monti, Daniela, Lazzarotto, Tiziana, Dal Monte, Paola, Pedrazzoni, Mario, Medici, Maria Cristina, Chezzi, Carlo, Franceschi, Claudio, Fagnoni, Francesco F, Sansoni, Paolo

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Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians von SANSONI, P, COSSARIZZA, A, FAGIOLO, U, PASSERI, M, FRANCESCHI, C, BRIANTI, V, FAGNONI, F, SNELLI, G, MONTI, D, MARCATO, A, PASSERI, G, ORTOLANI, C, FORTI, E

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Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2 von GENNARI, Roberto, MENARD, Sylvie, OLIVIERO, Barbara, BALLARDINI, Bettina, DA PRADA, Gianantonio, ZAMBELLI, Alberto, COSTA, Alberto, FAGNONI, Francesco, PONCHIO, Luisa, SCELSI, Mario, TAGLIABUE, Elda, CASTIGLIONI, Fabio, VILLANI, Laura, MAGALOTTI, Cesare, GIBELLI, Nadia

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T‐cell dynamics after high‐dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T‐cell compartments with distinct implications for immun... von Fagnoni, Francesco F., Lozza, Laura, Zibera, Carlo, Zambelli, Alberto, Ponchio, Luisa, Gibelli, Nadia, Oliviero, Barbara, Pavesi, Lorenzo, Gennari, Roberto, Vescovini, Rosanna, Sansoni, Paolo, Da Prada, Gianantonio, Robustelli Della Cuna, Gioacchino

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Cytotoxic chemotherapy preceding apheresis of peripheral blood progenitor cells can affect the early reconstitution phase of naive T cells after autologous transplantation von FAGNONI, F. F, LOZZA, L, DA PRADA, G, DELLA CUNA, G. Robustelli, ZIBERA, C, ZAMBELLI, A, GIBELLI, N, OLIVIERO, B, PONCHIO, L, FREGONI, V, PAVESI, L, PEROTTI, C

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Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6 von Ratta, Marina, Fagnoni, Francesco, Curti, Antonio, Vescovini, Rosanna, Sansoni, Paolo, Oliviero, Barbara, Fogli, Miriam, Ferri, Elisa, Della Cuna, Gioacchino Robustelli, Tura, Sante, Baccarani, Michele, Lemoli, Roberto M.

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353 NATURAL KILLER CELL FUNCTION IS ENHANCED AFTER HCC RADIOFREQUENCY THERMAL ABLATION: RATIONAL FOR THE DEVELOPMENT OF ADJUVANT IMMUNOTHERAPY von Zerbini, A, Pilli, M, Pelosi, G, Negri, E, Molinari, A, Tola, D, Laccabue, D, Cavallo, C, Fagnoni, F, Ferrari, C, Missale, G

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Radiofrequency thermal ablation of hepatocellular carcinoma (HCC) can enhance NK cell response von Zerbini, A, Pilli, M, Pelosi, G, Negri, E, Molinari, A, Laccabue, D, Cerioni, S, Fagnoni, F, Ferrari, C, Missale, G

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The enhancement of NK-cell function after radiofrequency thermal ablation for HCC is predictive of clinical outcome von Zerbini, A, Pilli, M, Pelosi, G, Biasini, E, Negri, E, Molinari, A, Laccabue, D, Cerioni, S, Fagnoni, F, Ferrari, C, Missale, G

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