Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-la... von Marabelle, Aurélien, Fakih, Marwan, Lopez, Juanita, Shah, Manisha, Shapira-Frommer, Ronnie, Nakagawa, Kazuhiko, Chung, Hyun Cheol, Kindler, Hedy L, Lopez-Martin, Jose A, Miller, Wilson H, Italiano, Antoine, Kao, Steven, Piha-Paul, Sarina A, Delord, Jean-Pierre, McWilliams, Robert R, Fabrizio, David A, Aurora-Garg, Deepti, Xu, Lei, Jin, Fan, Norwood, Kevin, Bang, Yung-Jue

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A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient S... von Trabucco, Sally E., Gowen, Kyle, Maund, Sophia L., Sanford, Eric, Fabrizio, David A., Hall, Michael J., Yakirevich, Evgeny, Gregg, Jeffrey P., Stephens, Phil J., Frampton, Garrett M., Hegde, Priti S., Miller, Vincent A., Ross, Jeffrey S., Hartmaier, Ryan J., Huang, Shih-Min A., Sun, James X.

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Addressing the gap in precision medicine von Fabrizio, David A

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Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial von Peters, Solange, Dziadziuszko, Rafal, Morabito, Alessandro, Felip, Enriqueta, Gadgeel, Shirish M., Cheema, Parneet, Cobo, Manuel, Andric, Zoran, Barrios, Carlos H., Yamaguchi, Masafumi, Dansin, Eric, Danchaivijitr, Pongwut, Johnson, Melissa, Novello, Silvia, Mathisen, Michael S., Shagan, Sarah M., Schleifman, Erica, Wang, Jin, Yan, Mark, Mocci, Simonetta, Voong, David, Fabrizio, David A., Shames, David S., Riehl, Todd, Gandara, David R., Mok, Tony

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Blood-based tumor mutational burden as a biomarker for atezolizumab in non-small cell lung cancer: the phase 2 B-F1RST trial von Kim, Edward S., Velcheti, Vamsidhar, Mekhail, Tarek, Yun, Cindy, Shagan, Sarah M., Hu, Sylvia, Chae, Young Kwang, Leal, Ticiana A., Dowell, Jonathan E., Tsai, Michaela L., Dakhil, Christopher S. R., Stella, Philip, Jin, Yanling, Shames, David S., Schleifman, Erica, Fabrizio, David A., Phan, See, Socinski, Mark A.

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Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden von Chalmers, Zachary R, Connelly, Caitlin F, Fabrizio, David, Gay, Laurie, Ali, Siraj M, Ennis, Riley, Schrock, Alexa, Campbell, Brittany, Shlien, Adam, Chmielecki, Juliann, Huang, Franklin, He, Yuting, Sun, James, Tabori, Uri, Kennedy, Mark, Lieber, Daniel S, Roels, Steven, White, Jared, Otto, Geoffrey A, Ross, Jeffrey S, Garraway, Levi, Miller, Vincent A, Stephens, Phillip J, Frampton, Garrett M

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Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3 von Ross, Jeffrey S., Fakih, Marwan, Ali, Siraj M., Elvin, Julia A., Schrock, Alexa B., Suh, James, Vergilio, Jo‐Anne, Ramkissoon, Shakti, Severson, Eric, Daniel, Sugganth, Fabrizio, David, Frampton, Garrett, Sun, James, Miller, Vincent A., Stephens, Philip J., Gay, Laurie M.

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Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition von Fabrizio, David A, George, Jr, Thomas J, Dunne, Richard F, Frampton, Garrett, Sun, James, Gowen, Kyle, Kennedy, Mark, Greenbowe, Joel, Schrock, Alexa B, Hezel, Aram F, Ross, Jeffrey S, Stephens, Phillip J, Ali, Siraj M, Miller, Vincent A, Fakih, Marwan, Klempner, Samuel J

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Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response von Montesion, Meagan, Murugesan, Karthikeyan, Jin, Dexter X, Sharaf, Radwa, Sanchez, Nora, Guria, Ameet, Minker, Max, Li, Gerald, Fisher, Virginia, Sokol, Ethan S, Pavlick, Dean C, Moore, Jay A, Braly, Alan, Singal, Gaurav, Fabrizio, David, Comment, Leah A, Rizvi, Naiyer A, Alexander, Brian M, Frampton, Garrett M, Hegde, Priti S, Albacker, Lee A

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Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High‐Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures von Johnson, Adrienne, Severson, Eric, Gay, Laurie, Vergilio, Jo‐Anne, Elvin, Julia, Suh, James, Daniel, Sugganth, Covert, Mandy, Frampton, Garrett M., Hsu, Sigmund, Lesser, Glenn J., Stogner‐Underwood, Kimberly, Mott, Ryan T., Rush, Sarah Z., Stanke, Jennifer J., Dahiya, Sonika, Sun, James, Reddy, Prasanth, Chalmers, Zachary R., Erlich, Rachel, Chudnovsky, Yakov, Fabrizio, David, Schrock, Alexa B., Ali, Siraj, Miller, Vincent, Stephens, Philip J., Ross, Jeffrey, Crawford, John R., Ramkissoon, Shakti H.

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Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial von Mercadante, Sebastiano, David, Fabrizio, Villari, Patrizia, Spedale, Vincenza Manuela, Casuccio, Alessandra

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Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors von Lee, Jessica K., Sivakumar, Smruthy, Schrock, Alexa B., Madison, Russell, Fabrizio, David, Gjoerup, Ole, Ross, Jeffrey S., Frampton, Garrett M., Napalkov, Pavel, Montesion, Meagan, Schutzman, Jennifer L., Ye, Xin, Hegde, Priti S., Nagasaka, Misako, Oxnard, Geoffrey R., Sokol, Ethan S., Ou, Sai-Hong Ignatius, Shi, Zhen

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Genomic immunotherapy (IO) biomarkers detected on comprehensive genomic profiling (CGP) of tissue and circulating tumor DNA (ctDNA) von Yoshino, Takayuki, Tukachinsky, Hanna, Lee, Jessica Kim, Sokol, Ethan, Pavlick, Dean C., Aiyer, Aparna, Fabrizio, David, Venstrom, Jeffrey Michael, Mishima, Saori, Nakamura, Yoshiaki, Oxnard, Geoffrey R.

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Fast-track anesthesia and outcomes in hepatopancreatic cancer surgery: a retrospective analysis von Mercadante, Sebastiano, David, Fabrizio, Mandalà, Lucio, Villari, Patrizia, Mezzatesta, Pietro, Casuccio, Alessandra

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DRAGON, a Bone Morphogenetic Protein Co-receptor von Samad, Tarek A., Rebbapragada, Anuradha, Bell, Esther, Zhang, Ying, Sidis, Yisrael, Jeong, Sung-Jin, Campagna, Jason A., Perusini, Stephen, Fabrizio, David A., Schneyer, Alan L., Lin, Herbert Y., Brivanlou, Ali H., Attisano, Liliana, Woolf, Clifford J.

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Deletions on 9p21 are associated with worse outcomes after anti-PD-1/PD-L1 monotherapy but not chemoimmunotherapy von Ebot, Ericka M., Duncan, Daniel L., Tolba, Khaled, Fabrizio, David, Frampton, Garrett M., Comment, Leah A., Albacker, Lee A.

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Controlled Sedation for Refractory Symptoms in Dying Patients von Mercadante, Sebastiano, MD, Intravaia, Giuseppe, RN, Villari, Patrizia, MD, Ferrera, Patrizia, MD, David, Fabrizio, MD, Casuccio, Alessandra, BS

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TMB standardization by alignment to reference standards: Phase II of the Friends of Cancer Research TMB Harmonization Project von Merino, Diana M., McShane, Lisa, Butler, Matt, Funari, Vincent Anthony, Hellmann, Matthew David, Chaudhary, Ruchi, Chen, Shu-Jen, Chen, Wangjuh Sting, Conroy, Jeffrey M., Fabrizio, David, MacConaill, Laura E, Pallavajjala, Aparna, Papin, Arnaud, Sausen, Mark, Weigman, Victor J, Xie, Mingchao, Zehir, Ahmet, Zhao, Chen, Williams, Paul M.

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Evaluation of tissue- and plasma-derived tumor mutational burden (TMB) and genomic alterations of interest in CheckMate 848, a study of nivolumab combined with ipilimumab and nivol... von He, Jie, Kalinava, Natallia, Doshi, Parul, Pavlick, Dean C, Albacker, Lee A, Ebot, Ericka M, Tukachinsky, Hanna, Pratt, James, Fusaro, Gina, Oxnard, Geoffrey R, Green, George, Fabrizio, David, Baden, Jonathan

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Breakthrough Pain in Oncology: A Longitudinal Study von Mercadante, Sebastiano, MD, Zagonel, Vittoria, MD, Breda, Enrico, MD, Arcara, Carlo, MD, Gebbia, Vittorio, MD, Porzio, Giampiero, MD, Aielli, Federica, MD, David, Fabrizio, MD, Gammucci, Teresa, MD, Narducci, Filomena, MD, Lanzetta, Gaetano, MD, Restuccia, Rossella, MD, Lembo, Alessandro, MD, Passeri, Virginia, MD, Virzì, Vladimir, MD, Casuccio, Alessandra, BS

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