Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease von Eyers, Patrick A, Keeshan, Karen, Kannan, Natarajan

Volltext

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation von Hardman, Gemma, Perkins, Simon, Brownridge, Philip J, Clarke, Christopher J, Byrne, Dominic P, Campbell, Amy E, Kalyuzhnyy, Anton, Myall, Ashleigh, Eyers, Patrick A, Jones, Andrew R, Eyers, Claire E

Volltext

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential von Meyer, Bjoern, Chiaravalli, Jeanne, Gellenoncourt, Stacy, Brownridge, Philip, Bryne, Dominic P., Daly, Leonard A., Grauslys, Arturas, Walter, Marius, Agou, Fabrice, Chakrabarti, Lisa A., Craik, Charles S., Eyers, Claire E., Eyers, Patrick A., Gambin, Yann, Jones, Andrew R., Sierecki, Emma, Verdin, Eric, Vignuzzi, Marco, Emmott, Edward

Volltext

Local protein kinase A action proceeds through intact holoenzymes von Smith, F. Donelson, Esseltine, Jessica L., Nygren, Patrick J., Veesler, David, Byrne, Dominic P., Vonderach, Matthias, Strashnov, Ilya, Eyers, Claire E., Eyers, Patrick A., Langeberg, Lorene K., Scott, John D.

Volltext

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease von Reiterer, Veronika, Eyers, Patrick A, Farhan, Hesso

Volltext

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity von Byrne, Dominic P., Shrestha, Safal, Galler, Martin, Cao, Min, Daly, Leonard A., Campbell, Amy E., Eyers, Claire E., Veal, Elizabeth A., Kannan, Natarajan, Eyers, Patrick A.

Volltext

Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes von Bury, Leah, Coelho, Paula A, Simeone, Angela, Ferries, Samantha, Eyers, Claire E, Eyers, Patrick A, Zernicka-Goetz, Magdalena, Glover, David M

Volltext

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells von Foulkes, Daniel M, Byrne, Dominic P, Yeung, Wayland, Shrestha, Safal, Bailey, Fiona P, Ferries, Samantha, Eyers, Claire E, Keeshan, Karen, Wells, Carrow, Drewry, David H, Zuercher, William J, Kannan, Natarajan, Eyers, Patrick A

Volltext

Tracing the origin and evolution of pseudokinases across the tree of life von Kwon, Annie, Scott, Steven, Taujale, Rahil, Yeung, Wayland, Kochut, Krys J, Eyers, Patrick A, Kannan, Natarajan

Volltext

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome von Wilson, Leah J, Linley, Adam, Hammond, Dean E, Hood, Fiona E, Coulson, Judy M, MacEwan, David J, Ross, Sarah J, Slupsky, Joseph R, Smith, Paul D, Eyers, Patrick A, Prior, Ian A

Volltext

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL von Greaves, Georgia, Milani, Mateus, Butterworth, Michael, Carter, Rachel J., Byrne, Dominic P., Eyers, Patrick A., Luo, Xu, Cohen, Gerald M., Varadarajan, Shankar

Volltext

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner von Bailey, Fiona P, Byrne, Dominic P, Oruganty, Krishnadev, Eyers, Claire E, Novotny, Christopher J, Shokat, Kevan M, Kannan, Natarajan, Eyers, Patrick A

Volltext

TRIBBLES: A Twist in the Pseudokinase Tail von Eyers, Patrick A.

Volltext

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties von Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S

Volltext

Covalent Aurora A regulation by the metabolic integrator coenzyme A von Tsuchiya, Yugo, Byrne, Dominic P., Burgess, Selena G., Bormann, Jenny, Baković, Jovana, Huang, Yueyang, Zhyvoloup, Alexander, Yu, Bess Yi Kun, Peak-Chew, Sew, Tran, Trang, Bellany, Fiona, Tabor, Alethea B., Chan, AW Edith, Guruprasad, Lalitha, Garifulin, Oleg, Filonenko, Valeriy, Vonderach, Matthias, Ferries, Samantha, Eyers, Claire E., Carroll, John, Skehel, Mark, Bayliss, Richard, Eyers, Patrick A., Gout, Ivan

Volltext

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases von Venkat, Aarya, Watterson, Grace, Byrne, Dominic P, O'Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E, Daly, Leonard A, Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E, Eyers, Patrick A, Kannan, Natarajan

Volltext

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota von Luis, Ana S, Baslé, Arnaud, Byrne, Dominic P., Wright, Gareth S. A., London, James A., Jin, Chunsheng, Karlsson, Niclas G., Hansson, Gunnar C., Eyers, Patrick A., Czjzek, Mirjam, Barbeyron, Tristan, Yates, Edwin A., Martens, Eric C., Cartmell, Alan

Volltext

KinView: a visual comparative sequence analysis tool for integrated kinome research von McSkimming, Daniel Ian, Dastgheib, Shima, Baffi, Timothy R, Byrne, Dominic P, Ferries, Samantha, Scott, Steven Thomas, Newton, Alexandra C, Eyers, Claire E, Kochut, Krzysztof J, Eyers, Patrick A, Kannan, Natarajan

Volltext

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases von Huang, Liang-Chin, Taujale, Rahil, Gravel, Nathan, Venkat, Aarya, Yeung, Wayland, Byrne, Dominic P, Eyers, Patrick A, Kannan, Natarajan

Volltext

A framework for identification of actionable cancer genome dependencies in small cell lung cancer von Sos, Martin L., Dietlein, Felix, Peifer, Martin, Schöttle, Jakob, Balke-Want, Hyatt, Müller, Christian, Koker, Mirjam, Richters, André, Heynck, Stefanie, Malchers, Florian, Heuckmann, Johannes M., Seidel, Danila, Eyers, Patrick A., Ullrich, Rolad T., Antonchick, Andrey P., Vintonyak, Viktor V., Schneider, Peter M., Ninomiya, Takashi, Waldmann, Herbert, Büttner, Reinhard, Rauh, Daniel, Heukamp, Lukas C., Thomas, Roman K.

Volltext