Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange von Labrijn, Aran F, Meesters, Joyce I, de Goeij, Bart E C G, van den Bremer, Ewald T J, Neijssen, Joost, van Kampen, Muriel D, Strumane, Kristin, Verploegen, Sandra, Kundu, Amitava, Gramer, Michael J, van Berkel, Patrick H C, van de Winkel, Jan G J, Schuurman, Janine, Parren, Paul W H I

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Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose von Gramer, Michael J., Eckblad, Jackie J., Donahue, Ruth, Brown, Joseph, Shultz, Carrie, Vickerman, Kent, Priem, Patrick, van den Bremer, Ewald T.J., Gerritsen, Jolanda, van Berkel, Patrick H.C.

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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen von Wang, Guanbo, de Jong, Rob N., van den Bremer, Ewald T.J., Beurskens, Frank J., Labrijn, Aran F., Ugurlar, Deniz, Gros, Piet, Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

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Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selec... von Dyachenko, Andrey, Wang, Guanbo, Belov, Mike, Makarov, Alexander, de Jong, Rob N, van den Bremer, Ewald T. J, Parren, Paul W. H. I, Heck, Albert J. R

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Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry von Wang, Guanbo, de Jong, Rob N, van den Bremer, Ewald T. J, Parren, Paul W. H. I, Heck, Albert J. R

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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo von Labrijn, Aran F, Buijsse, Antonio Ortiz, van den Bremer, Ewald T J, Verwilligen, Annemiek Y W, Bleeker, Wim K, Thorpe, Susan J, Killestein, Joep, Polman, Chris H, Aalberse, Rob C, Schuurman, Janine, van de Winkel, Jan G J, Parren, Paul W H I

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Controlled Fab-arm exchange for the generation of stable bispecific IgG1 von Labrijn, Aran F, Meesters, Joyce I, Priem, Patrick, de Jong, Rob N, van den Bremer, Ewald T J, van Kampen, Muriel D, Gerritsen, Arnout F, Schuurman, Janine, Parren, Paul W H I

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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xeno... von Johnson, Spenser S., Liu, Dijie, Ewald, Jordan T., Robles-Planells, Claudia, Pulliam, Casey, Christensen, Keegan A., Bayanbold, Khaliunaa, Wels, Brian R., Solst, Shane R., O'Dorisio, M. Sue, Menda, Yusuf, Spitz, Douglas R., Fath, Melissa A.

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In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spec... von Rosati, Sara, van den Bremer, Ewald TJ, Schuurman, Janine, Parren, Paul WHI, Kamerling, Johannis P, Heck, Albert JR

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Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength von Labrijn, Aran F, Rispens, Theo, Meesters, Joyce, Rose, Rebecca J, den Bleker, Tamara H, Loverix, Stefan, van den Bremer, Ewald T J, Neijssen, Joost, Vink, Tom, Lasters, Ignace, Aalberse, Rob C, Heck, Albert J R, van de Winkel, Jan G J, Schuurman, Janine, Parren, Paul W H I

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Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities von van Kampen, Muriel D., Kuipers-De Wilt, Leonie H.A.M., van Egmond, Mariëlle L., Reinders-Blankert, Petra, van den Bremer, Ewald T.J., Wang, Guanbo, Heck, Albert J.R., Parren, Paul W.H.I., Beurskens, Frank J., Schuurman, Janine, de Jong, Rob N.

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Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecifi... von van den Bremer, Ewald T. J, Labrijn, Aran F, van den Boogaard, Ramon, Priem, Patrick, Scheffler, Kai, Melis, Joost P. M, Schuurman, Janine, Parren, Paul W. H. I, de Jong, Rob N

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Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation von van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patrick HC, Parren, Paul WHI

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry von Rose, Rebecca J., Labrijn, Aran F., van den Bremer, Ewald T.J., Loverix, Stefan, Lasters, Ignace, van Berkel, Patrick H.C., van de Winkel, Jan G.J., Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

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Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches von Gramer, Michael J, van den Bremer, Ewald TJ, van Kampen, Muriel D, Kundu, Amitava, Kopfmann, Peter, Etter, Eric, Stinehelfer, David, Long, Justin, Lannom, Tom, Noordergraaf, Esther H, Gerritsen, Jolanda, Labrijn, Aran F, Schuurman, Janine, van Berkel, Patrick HC, Parren, Paul WHI

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Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection von Ewald, Jordan T, Steinbrekera, Baiba, Bermick, Jennifer R, Santillan, Donna A, Colaizy, Tarah T, Santillan, Mark K, Roghair, Robert D

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Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG von Rose, Rebecca J., van Berkel, Patrick H.C., van den Bremer, Ewald T.J., Labrijn, Aran F., Vink, Tom, Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.

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Is Childhood Sexual Abuse Related to Self-Injurious Behavior? von Ewald, T.M., MD

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Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints von Walker, J A, Ewald, T J, Lewallen, E, Van Wijnen, A, Hanssen, A D, Morrey, B F, Morrey, M E, Abdel, M P, Sanchez-Sotelo, J

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Tissue mechanics regulate brain development, homeostasis and disease von Barnes, J Matthew, Przybyla, Laralynne, Weaver, Valerie M

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