Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors von Shang, Xun, Marchioni, Fillipo, Evelyn, Chris R., Sipes, Nisha, Zhou, Xuan, Seibel, William, Wortman, Matthew, Zheng, Yi

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Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth von Tan, Zongqing, Wortman, Matthew, Dillehay, Kelsey L., Seibel, William L., Evelyn, Chris R., Smith, Shanna J., Malkas, Linda H., Zheng, Yi, Lu, Shan, Dong, Zhongyun

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Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance von Kesarwani, Meenu, Huber, Erika, Kincaid, Zachary, Evelyn, Chris R., Biesiada, Jacek, Rance, Mark, Thapa, Mahendra B., Shah, Neil P., Meller, Jarek, Zheng, Yi, Azam, Mohammad

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CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling von Evelyn, Chris R, Wade, Susan M, Wang, Qin, Wu, Mei, Iñiguez-Lluhí, Jorge A, Merajver, Sofia D, Neubig, Richard R

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Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423 von Evelyn, Chris R., Bell, Jessica L., Ryu, Jenny G., Wade, Susan M., Kocab, Andrew, Harzdorf, Nicole L., Hollis Showalter, H.D., Neubig, Richard R., Larsen, Scott D.

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A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells von Aittaleb, Mohamed, Gao, Guang, Evelyn, Chris R., Neubig, Richard R., Tesmer, John J.G.

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Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme von Evelyn, Chris R., Biesiada, Jacek, Duan, Xin, Tang, Hong, Shang, Xun, Papoian, Ruben, Seibel, William L., Nelson, Sandra, Meller, Jaroslaw, Zheng, Yi

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Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs von Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J.G

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Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases von Shang, Xun, Marchioni, Fillipo, Sipes, Nisha, Evelyn, Chris R., Jerabek-Willemsen, Moran, Duhr, Stefan, Seibel, William, Wortman, Matthew, Zheng, Yi

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Rational Design of Small Molecule Inhibitors Targeting the Ras GEF, SOS1 von Evelyn, Chris R., Duan, Xin, Biesiada, Jacek, Seibel, William L., Meller, Jaroslaw, Zheng, Yi

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High-Throughput Screening for Small-Molecule Inhibitors of LARG-Stimulated RhoA Nucleotide Binding via a Novel Fluorescence Polarization Assay von Evelyn, Chris R., Ferng, Timothy, Rojas, Rafael J., Larsen, Martha J., Sondek, John, Neubig, Richard R.

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Structure of G[alpha]q-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs von Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J G

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Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks von Evelyn, Chris R, Lisabeth, Erika M, Wade, Susan M, Haak, Andrew J, Johnson, Craig N, Lawlor, Elizabeth R, Neubig, Richard R

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Structure of$\text{G}\alpha _{\text{q}}-\text{p}63\text{RhoGEF}-\text{RhoA}$Complex Reveals a Pathway for the Activation of RhoA by GPCRs von Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R., Vettel, Christiane, Baltus, Doris, Evelyn, Chris R., Neubig, Richard R., Wieland, Thomas, Tesmer, John J. G.

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Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs von Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J G

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The antimicrobial potential of Streptomyces from insect microbiomes von Chevrette, Marc G., Carlson, Caitlin M., Ortega, Humberto E., Thomas, Chris, Ananiev, Gene E., Barns, Kenneth J., Book, Adam J., Cagnazzo, Julian, Carlos, Camila, Flanigan, Will, Grubbs, Kirk J., Horn, Heidi A., Hoffmann, F. Michael, Klassen, Jonathan L., Knack, Jennifer J., Lewin, Gina R., McDonald, Bradon R., Muller, Laura, Melo, Weilan G. P., Pinto-Tomás, Adrián A., Schmitz, Amber, Wendt-Pienkowski, Evelyn, Wildman, Scott, Zhao, Miao, Zhang, Fan, Bugni, Tim S., Andes, David R., Pupo, Monica T., Currie, Cameron R.

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A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family von Clarke, Bradley R., Ovchinnikova, Olga G., Sweeney, Ryan P., Kamski-Hennekam, Evelyn R., Gitalis, Russel, Mallette, Evan, Kelly, Steven D., Lowary, Todd L., Kimber, Matthew S., Whitfield, Chris

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Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients von de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul

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IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase–associated lipocalin during acute kidney injury von Skrypnyk, Nataliya I., Gist, Katja M., Okamura, Kayo, Montford, John R., You, Zhiying, Yang, Haichun, Moldovan, Radu, Bodoni, Evelyn, Blaine, Judith T., Edelstein, Charles L., Soranno, Danielle E., Kirkbride-Romeo, Lara A., Griffin, Benjamin R., Altmann, Chris, Faubel, Sarah

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Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis von Tacconelli, Evelina, Carrara, Elena, Savoldi, Alessia, Harbarth, Stephan, Mendelson, Marc, Monnet, Dominique L, Pulcini, Céline, Kahlmeter, Gunnar, Kluytmans, Jan, Carmeli, Yehuda, Ouellette, Marc, Outterson, Kevin, Patel, Jean, Cavaleri, Marco, Cox, Edward M, Houchens, Chris R, Grayson, M Lindsay, Hansen, Paul, Singh, Nalini, Theuretzbacher, Ursula, Magrini, Nicola, Aboderin, Aaron Oladipo, Al-Abri, Seif Salem, Awang Jalil, Nordiah, Benzonana, Nur, Bhattacharya, Sanjay, Brink, Adrian John, Burkert, Francesco Robert, Cars, Otto, Cornaglia, Giuseppe, Dyar, Oliver James, Friedrich, Alex W, Gales, Ana C, Gandra, Sumanth, Giske, Christian Georg, Goff, Debra A, Goossens, Herman, Gottlieb, Thomas, Guzman Blanco, Manuel, Hryniewicz, Waleria, Kattula, Deepthi, Jinks, Timothy, Kanj, Souha S, Kerr, Lawrence, Kieny, Marie-Paule, Kim, Yang Soo, Kozlov, Roman S, Labarca, Jaime, Laxminarayan, Ramanan, Leder, Karin, Leibovici, Leonard, Levy-Hara, Gabriel, Littman, Jasper, Malhotra-Kumar, Surbhi, Manchanda, Vikas, Moja, Lorenzo, Ndoye, Babacar, Pan, Angelo, Paterson, David L, Paul, Mical, Qiu, Haibo, Ramon-Pardo, Pilar, Rodríguez-Baño, Jesús, Sanguinetti, Maurizio, Sengupta, Sharmila, Sharland, Mike, Si-Mehand, Massinissa, Silver, Lynn L, Song, Wonkeung, Steinbakk, Martin, Thomsen, Jens, Thwaites, Guy E, van der Meer, Jos WM, Van Kinh, Nguyen, Vega, Silvio, Villegas, Maria Virginia, Wechsler-Fördös, Agnes, Wertheim, Heiman Frank Louis, Wesangula, Evelyn, Woodford, Neil, Yilmaz, Fidan O, Zorzet, Anna

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