Preclinical evaluation of Insulin-like growth factor receptor 1 (IGF1R) and Insulin Receptor (IR) as a therapeutic targets in triple negative breast cancer von Roche, Sandra, Gaule, Patricia, Winrow, Deirdre, Mukherjee, Nupur, O'Neill, Fiona, Conlon, Neil T, Meiller, Justine, Collins, Denis M, Canonici, Alexandra, Fawsi, Mohammed Ibrahim, Estepa-Fernández, Alejandra, Madden, Stephen F, Crown, John, O'Donovan, Norma, Eustace, Alex J

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Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines von Eustace, Alex J, Crown, John, Clynes, Martin, O'Donovan, Norma

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Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL von Eustace, Alex J, Conlon, Neil T, McDermott, Martina S J, Browne, Brigid C, O'Leary, Patrick, Holmes, Frankie A, Espina, Virginia, Liotta, Lance A, O'Shaughnessy, Joyce, Gallagher, Clair, O'Driscoll, Lorraine, Rani, Sweta, Madden, Stephen F, O'Brien, Neil A, Ginther, Charles, Slamon, Dennis, Walsh, Naomi, Gallagher, William M, Zagozdzon, Radoslaw, Watson, William R, O'Donovan, Norma, Crown, John

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The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells von Glynn, Sharon A, O'Sullivan, Dermot, Eustace, Alex J, Clynes, Martin, O'Donovan, Norma

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Pilot study of bevacizumab in combination with docetaxel and cyclophosphamide as adjuvant treatment for patients with early stage HER-2 negative breast cancer, including analysis o... von Gullo, Giuseppe, Eustace, Alex J., Canonici, Alexandra, Collins, Denis M., Kennedy, Michael J., Grogan, Liam, Breathhnach, Oscar, McCaffrey, John, Keane, Maccon, Martin, Michael J., Gupta, Rajnish, Leonard, Gregory, O’Connor, Miriam, Calvert, Paula M., Donnellan, Paul, Walshe, Janice, McDermott, Enda, Scott, Kathleen, Hernando, Andres, Parker, Imelda, Murray, David W., O’Farrell, Alice C., Maratha, Ashwini, Dicker, Patrick, Rafferty, Mairin, Murphy, Verena, O’Donovan, Norma, Gallagher, William M., Ky, Bonnie, Tryfonopoulos, Dimitrios, Moulton, Brian, Byrne, Annette T., Crown, John

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Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer von Canonici, Alexandra, Browne, Alacoque L., Ibrahim, Mohamed F. K., Fanning, Kevin P., Roche, Sandra, Conlon, Neil T., O’Neill, Fiona, Meiller, Justine, Cremona, Mattia, Morgan, Clare, Hennessy, Bryan T., Eustace, Alex J., Solca, Flavio, O’Donovan, Norma, Crown, John

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Predictive modelling of response to neoadjuvant therapy in HER2+ breast cancer von Cosgrove, Nicola, Eustace, Alex J., O’Donovan, Peter, Madden, Stephen F., Moran, Bruce, Crown, John, Moulton, Brian, Morris, Patrick G., Grogan, Liam, Breathnach, Oscar, Power, Colm, Allen, Michael, Walshe, Janice M., Hill, Arnold D., Blümel, Anna, O’Connor, Darren, Das, Sudipto, Milewska, Małgorzata, Fay, Joanna, Kay, Elaine, Toomey, Sinead, Hennessy, Bryan T., Furney, Simon J.

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In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies von McDermott, Martina, Eustace, Alex J, Busschots, Steven, Breen, Laura, Crown, John, Clynes, Martin, O'Donovan, Norma, Stordal, Britta

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Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers von Milewska, Malgorzata, Cremona, Mattia, Morgan, Clare, O’Shea, John, Carr, Aoife, Vellanki, Sri HariKrishna, Hopkins, Ann M., Toomey, Sinead, Madden, Stephen F., Hennessy, Bryan T., Eustace, Alex J.

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Effects of HER Family-targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer von Collins, Denis M., Madden, Stephen F., Gaynor, Nicola, AlSultan, Dalal, Le Gal, Marion, Eustace, Alex J., Gately, Kathy A., Hughes, Clare, Davies, Anthony M., Mahgoub, Thamir, Ballot, Jo, Toomey, Sinead, O'Connor, Darran P., Gallagher, William M., Holmes, Frankie A., Espina, Virginia, Liotta, Lance, Hennessy, Bryan T., O'Byrne, Kenneth J., Hasmann, Max, Bossenmaier, Birgit, O'Donovan, Norma, Crown, John

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Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer von Kennedy, Sean P., O’Neill, Michael, Cunningham, Darren, Morris, Patrick G., Toomey, Sinead, Blanco-Aparicio, Carmen, Martinez, Sonia, Pastor, Joaquin, Eustace, Alex J., Hennessy, Bryan T.

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Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy von Gaynor, Nicola, Blanco, Alfonso, Madden, Stephen F., Moran, Barry, Fletcher, Jean M., Kaukonen, Damien, Ramírez, Javier Sánchez, Eustace, Alex J., McDermott, Martina S. J., Canonici, Alexandra, Toomey, Sinead, Teiserskiene, Ausra, Hennessy, Bryan T., O’Donovan, Norma, Crown, John, Collins, Denis M.

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The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells von AlSultan, Dalal, Kavanagh, Emma, O’Grady, Shane, Eustace, Alex J, Castell, Alina, Larsson, Lars-Gunnar, Crown, John, Madden, Stephen F, Duffy, Michael J

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Precision Oncology, Artificial Intelligence, and Novel Therapeutic Advancements in the Diagnosis, Prevention, and Treatment of Cancer: Highlights from the 59th Irish Association fo... von Lynch, Seodhna M, Heeran, Aisling B, Burke, Caoimbhe, Lynam-Lennon, Niamh, Eustace, Alex J, Dean, Kellie, Robson, Tracy, Rahman, Arman, Marcone, Simone

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Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference von Kennedy, Sean P, Treacy, Oliver, Allott, Emma H, Eustace, Alex J, Lynam-Lennon, Niamh, Buckley, Niamh, Robson, Tracy

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Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells von Gaule, Patricia, Mukherjee, Nupur, Corkery, Brendan, Eustace, Alex J, Gately, Kathy, Roche, Sandra, O'Connor, Robert, O'Byrne, Kenneth J, Walsh, Naomi, Duffy, Michael J, Crown, John, O'Donovan, Norma

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Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A von Breen, Laura, Gaule, Patricia B., Canonici, Alexandra, Walsh, Naomi, Collins, Denis M., Cremona, Mattia, Hennessy, Bryan T., Duffy, Michael J., Crown, John, Donovan, Norma O’, Eustace, Alex J.

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Predictive biomarkers for dasatinib treatment in melanoma von Eustace, Alex J, Kennedy, Susan, Larkin, Anne-Marie, Mahgoub, Thamir, Tryfonopoulos, Dimitrios, O'Driscoll, Lorraine, Clynes, Martin, Crown, John, O'Donovan, Norma

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The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells von Canonici, Alexandra, Qadir, Zulfiqar, Conlon, Neil T., Collins, Denis M., O’Brien, Neil A., Walsh, Naomi, Eustace, Alex J., O’Donovan, Norma, Crown, John

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Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer von Eustace, Alex J., Lee, Min Jie, Colley, Grace, Roban, Jack, Downing, Tim, Buchanan, Paul J.

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