KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells von Etchin, J, Berezovskaya, A, Conway, A S, Galinsky, I A, Stone, R M, Baloglu, E, Senapedis, W, Landesman, Y, Kauffman, M, Shacham, S, Wang, J C Y, Look, A T

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Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells von Etchin, J, Sun, Q, Kentsis, A, Farmer, A, Zhang, Z C, Sanda, T, Mansour, M R, Barcelo, C, McCauley, D, Kauffman, M, Shacham, S, Christie, A L, Kung, A L, Rodig, S J, Chook, Y M, Look, A T

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Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice von Etchin, J, Montero, J, Berezovskaya, A, Le, B T, Kentsis, A, Christie, A L, Conway, A S, Chen, W C, Reed, C, Mansour, M R, Ng, C E L, Adamia, S, Rodig, S J, Galinsky, I A, Stone, R M, Klebanov, B, Landesman, Y, Kauffman, M, Shacham, S, Kung, A L, Wang, J C Y, Letai, A, Look, A T

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P1429: MULTIPLEX DELETION OF MYELOID ANTIGENS CD33 AND CLL‐1 BY CRISPR/CAS9 IN HUMAN HEMATOPOIETIC STEM CELLS HIGHLIGHTS THE POTENTIAL OF NEXT‐GENERATION TRANSPLANTS FOR AML TREATM... von Xavier‐Ferrucio, J., Luo, C., Angelini, G., Krishnamurthy, S., Patel, N., Pettiglio, M., Collingsworth, T., Isik, M., Ghodssi, A., Halfond, A., Etchin, J., Keschner, Y., Mundelboim, G., Tavares, P., Cummins, C., Falla, A., Hazelbaker, D., Paik, E., Sanchez, J., Ge, G., Lydeard, J., Lin, M. I., Chakraborty, T.

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Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide von Filippo, Joseph San, Chi, Peter, Sehorn, Michael G., Etchin, Julia, Krejci, Lumir, Sung, Patrick

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Activity of a selective inhibitor of nuclear export, selinexor von Conway, A S, Etchin, J, Le, B T, Kentsis, A, Berezovskaya, A, Montero, J, Christie, A L

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KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells von Etchin, J, Berezovskaya, A, Conway, A S, Galinsky, I A, Stone, R M, Baloglu, E, Senapedis, W, Landesman, Y, Kauffman, M, Shacham, S, Wang, J C Y, Look, A T

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Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss von He, S, Zimmerman, MW, Layden, HM, Berezovskaya, A, Etchin, J, Martel, MW, Thurston, G, Jing, C-B, van Rooijen, E, Kaufman, CK, Rodig, SJ, Zon, LI, Patton, EE, Mansour, MR, Look, AT

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Small genomic insertions form enhancers that misregulate oncogenes von Abraham, BJ, Hnisz, D, Weintraub, AS, Kwiatkowski, N, Li, CH, Li, Z, Weichert-Leahey, N, Rahman, S, Liu, Y, Etchin, J, Li, B, Shen, S, Lee, TI, Zhang, J, Look, AT, Mansour, MR, Young, RA

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An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element von Mansour, MR, Abraham, BJ, Anders, L, Berezovskaya, A, Gutierrez, A, Durbin, AD, Etchin, J, Lawton, L, Sallan, SE, Silverman, LB, Loh, ML, Hunger, SP, Sanda, T, Young, RA, Look, AT

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Access to specialty healthcare in urban versus rural US populations: a systematic literature review von Cyr, Melissa E, Etchin, Anna G, Guthrie, Barbara J, Benneyan, James C

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An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element von Mansour, Marc R., Abraham, Brian J., Anders, Lars, Berezovskaya, Alla, Gutierrez, Alejandro, Durbin, Adam D., Etchin, Julia, Lawton, Lee, Sallan, Stephen E., Silverman, Lewis B., Loh, Mignon L., Hunger, Stephen P., Sanda, Takaomi, Young, Richard A., Look, A. Thomas

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In Situ Laboratory-Based Transmission X-Ray Microscopy and Tomography of Material Deformation at the Nanoscale von Patterson, B. M., Cordes, N. L., Henderson, K., Mertens, J. C. E., Clarke, A. J., Hornberger, B., Merkle, A., Etchin, S., Tkachuk, A., Leibowitz, M., Trapp, D., Qiu, W., Zhang, B., Bale, H., Lu, X., Hartwell, R., Withers, P. J., Bradley, R. S.

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Small genomic insertions form enhancers that misregulate oncogenes von Abraham, Brian J., Hnisz, Denes, Weintraub, Abraham S., Kwiatkowski, Nicholas, Li, Charles H., Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Lee, Tong Ihn, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Young, Richard A.

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Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss von He, Shuning, Zimmerman, Mark W., Layden, Hillary M., Berezovskaya, Alla, Etchin, Julia, Martel, Megan W., Thurston, Grace, Jing, Chang-Bin, van Rooijen, Ellen, Kaufman, Charles K., Rodig, Scott J., Zon, Leonard I., Patton, E. Elizabeth, Mansour, Marc R., Look, A. Thomas

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Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2 von Galkin, Vitold E, Etchin, Julia, Egelman, Edward, Yu, Xiong, Schild, David, Chen, Junjie, Wiese, Claudia, Williams, Gareth J, Sy, Shirley M-H, Sung, Patrick, Tsai, Miaw-Sheue, Dray, Eloïse, Saro, Dorina, Hammel, Michal, Liu, Dongqing

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KPT‐330 inhibitor of CRM1 (XPO1)‐mediated nuclear export has selective anti‐leukaemic activity in preclinical models of T‐cell acute lymphoblastic leukaemia and acute myeloid leuka... von Etchin, Julia, Sanda, Takaomi, Mansour, Marc R., Kentsis, Alex, Montero, Joan, Le, Bonnie T., Christie, Amanda L., McCauley, Dilara, Rodig, Scott J., Kauffman, Michael, Shacham, Sharon, Stone, Richard, Letai, Anthony, Kung, Andrew L., Thomas Look, A.

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Abstract 2953: Selective activity of XPO1 inhibitors in TET2-mutant myeloid malignancies von Prutsch, Nicole, Jing, Chang-Bin, Etchin, Julia, Berezovskaya, Alla, Tiv, Hong, Poitras, Michael J., Gokhale, Prafulla, Landesman, Yosef, Look, A. Thomas

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Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells von Barceló, Carles, Etchin, Julia, Mansour, Marc R, Sanda, Takaomi, Ginesta, Mireia M, Sanchez-Arévalo Lobo, Victor J, Real, Francisco X, Capellà, Gabriel, Estanyol, Josep M, Jaumot, Montserrat, Look, A. Thomas, Agell, Neus

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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice von Townsend, Elizabeth C., Murakami, Mark A., Christodoulou, Alexandra, Christie, Amanda L., Köster, Johannes, DeSouza, Tiffany A., Morgan, Elizabeth A., Kallgren, Scott P., Liu, Huiyun, Wu, Shuo-Chieh, Plana, Olivia, Montero, Joan, Stevenson, Kristen E., Rao, Prakash, Vadhi, Raga, Andreeff, Michael, Armand, Philippe, Ballen, Karen K., Barzaghi-Rinaudo, Patrizia, Cahill, Sarah, Clark, Rachael A., Cooke, Vesselina G., Davids, Matthew S., DeAngelo, Daniel J., Dorfman, David M., Eaton, Hilary, Ebert, Benjamin L., Etchin, Julia, Firestone, Brant, Fisher, David C., Freedman, Arnold S., Galinsky, Ilene A., Gao, Hui, Garcia, Jacqueline S., Garnache-Ottou, Francine, Graubert, Timothy A., Gutierrez, Alejandro, Halilovic, Ensar, Harris, Marian H., Herbert, Zachary T., Horwitz, Steven M., Inghirami, Giorgio, Intlekofer, Andrew M., Ito, Moriko, Izraeli, Shai, Jacobsen, Eric D., Jacobson, Caron A., Jeay, Sébastien, Jeremias, Irmela, Kelliher, Michelle A., Koch, Raphael, Konopleva, Marina, Kopp, Nadja, Kornblau, Steven M., Kung, Andrew L., Kupper, Thomas S., LeBoeuf, Nicole R., LaCasce, Ann S., Lees, Emma, Li, Loretta S., Look, A. Thomas, Murakami, Masato, Muschen, Markus, Neuberg, Donna, Ng, Samuel Y., Odejide, Oreofe O., Orkin, Stuart H., Paquette, Rachel R., Place, Andrew E., Roderick, Justine E., Ryan, Jeremy A., Sallan, Stephen E., Shoji, Brent, Silverman, Lewis B., Soiffer, Robert J., Steensma, David P., Stegmaier, Kimberly, Stone, Richard M., Tamburini, Jerome, Thorner, Aaron R., van Hummelen, Paul, Wadleigh, Martha, Wiesmann, Marion, Weng, Andrew P., Wuerthner, Jens U., Williams, David A., Wollison, Bruce M., Lane, Andrew A., Letai, Anthony, Bertagnolli, Monica M., Ritz, Jerome, Brown, Myles, Long, Henry, Aster, Jon C., Shipp, Margaret A., Griffin, James D., Weinstock, David M.

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