Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development von de Alwis, Ruklanthi, Chen, Shiwei, Gan, Esther S., Ooi, Eng Eong

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Dengue virus activates cGAS through the release of mitochondrial DNA von Sun, Bo, Sundström, Karin B., Chew, Jun Jie, Bist, Pradeep, Gan, Esther S., Tan, Hwee Cheng, Goh, Kenneth C., Chawla, Tanu, Tang, Choon Kit, Ooi, Eng Eong

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Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and... von Syenina, Ayesa, Gan, Esther S, Toh, Justin Z N, de Alwis, Ruklanthi, Lin, Lowell Z, Tham, Christine Y L, Yee, Jia Xin, Leong, Yan Shan, Sam, Huizhen, Cheong, Charlene, Teh, Yii Ean, Wee, Ian L E, Ng, Dorothy H L, Chan, Kuan Rong, Sim, Jean X Y, Kalimuddin, Shirin, Ong, Eugenia Z, Low, Jenny G, Ooi, Eng Eong

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Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development von Yau, Clement, Low, John Z.H., Gan, Esther S., Kwek, Swee Sen, Cui, Liang, Tan, Hwee Cheng, Mok, Darren Z.L., Chan, Candice Y.Y., Sessions, October M., Watanabe, Satoru, Vasudevan, Subhash G., Lee, Yie Hou, Chan, Kuan Rong, Ooi, Eng Eong

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A systematic approach to the development of a safe live attenuated Zika vaccine von Kwek, Swee Sen, Watanabe, Satoru, Chan, Kuan Rong, Ong, Eugenia Z., Tan, Hwee Cheng, Ng, Wy Ching, Nguyen, Mien T. X., Gan, Esther S., Zhang, Summer L., Chan, Kitti W. K., Tan, Jun Hao, Sessions, October M., Manuel, Menchie, Pompon, Julien, Chua, Camillus, Hazirah, Sharifah, Tryggvason, Karl, Vasudevan, Subhash G., Ooi, Eng Eong

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Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity von Enkirch, Theresa, Sauber, Svenja, Anderson, Danielle E, Gan, Esther S, Kenanov, Dimitar, Maurer-Stroh, Sebastian, von Messling, Veronika

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A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice von de Alwis, Ruklanthi, Gan, Esther S., Chen, Shiwei, Leong, Yan Shan, Tan, Hwee Cheng, Zhang, Summer L., Yau, Clement, Low, Jenny G.H., Kalimuddin, Shirin, Matsuda, Daiki, Allen, Elizabeth C., Hartman, Paula, Park, Kyoung-Joo Jenny, Alayyoubi, Maher, Bhaskaran, Hari, Dukanovic, Adrian, Bao, Yanjie, Clemente, Brenda, Vega, Jerel, Roberts, Scott, Gonzalez, Jose A., Sablad, Marciano, Yelin, Rodrigo, Taylor, Wendy, Tachikawa, Kiyoshi, Parker, Suezanne, Karmali, Priya, Davis, Jared, Sullivan, Brian M., Sullivan, Sean M., Hughes, Steve G., Chivukula, Pad, Ooi, Eng Eong

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A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection von Gan, Esther S., Syenina, Ayesa, Linster, Martin, Ng, Benson, Zhang, Summer L., Watanabe, Satoru, Rajarethinam, Ravisankar, Tan, Hwee Cheng, Smith, Gavin JD, Ooi, Eng Eong

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Dengue virus compartmentalization during antibody-enhanced infection von Ong, Eugenia Z., Zhang, Summer L., Tan, Hwee Cheng, Gan, Esther S., Chan, Kuan Rong, Ooi, Eng Eong

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The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses von Bigotti, Maria Giulia, Klein, Katja, Gan, Esther S., Anastasina, Maria, Andersson, Simon, Vapalahti, Olli, Katajisto, Pekka, Erdmann, Maximilian, Davidson, Andrew D., Butcher, Sarah J., Collinson, Ian, Ooi, Eng Eong, Balistreri, Giuseppe, Brancaccio, Andrea, Yamauchi, Yohei

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Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope von Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram

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Aviremic organ transplant dengue virus transmission – A case report von Sim, Jean X. Y., Gan, Esther S., Tan, Hwee C., Choy, Milly M., Wong, Hei M., Tan, Ban H., Kee, Terence, Ho, Quan Y., Thangaraju, Sobhana, Lin, Raymond T. P., Ooi, Eng E., Low, Jenny G.‐H.

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Genomic signature of early T-cell response is associated with lower antibody titer threshold for sterilizing immunity von Ong, Eugenia Z., Gan, Esther S., de Alwis, Ruklanthi, Wijaya, Limin, Ong, Xin Mei, Zhang, Menglan, Wong, Abigail WL, Cheung, Yin Bun, Zellweger, Raphaël M., Ooi, Eng Eong, Low, Jenny G.

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Abstract 13927: AAV Gene Therapy to Treat Underlying Cardiac Biomechanical Defects in Lmna Dilated Cardiomyopathy Improves Lifespan and Preserves Ejection Fraction in Lmna DCM Mous... von Werner, Hendrikje, Gan, Esther S, Loh, Connie Y, Khaing, Nyein Thet, Zhang, Jinqiu, Ong, Mervyn, Burke, Brian, Tan, Yann Chong, Stewart, Colin L, Lee, Yin Loon

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Abstract 12498: AAV-Mediated LINC Complex Uncoupling Ameliorates Pathology in a Mouse Model of LMNA Dilated Cardiomyopathy von Werner, Hendrikje, Gan, Esther S, Loh, Connie, Ng, Jennifer, Khaing, Nyein Thet, Zhang, Jinqiu, Ong, Mervyn, Lee, John, Russell, David W, Tan, Yann Chong, Stewart, Colin, Burke, Brian, Lee, Yin Loon

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Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and... von Ayesa Syenina, Esther S. Gan, Justin Z. N. Toh, Ruklanthi de Alwis, Lowell Z. Lin, Christine Y. L. Tham, Jia Xin Yee, Yan Shan Leong, Huizhen Sam, Charlene Cheong, Yii Ean Teh, Ian L. E. Wee, Dorothy H. L. Ng, Kuan Rong Chan, Jean X. Y. Sim, Shirin Kalimuddin, Eugenia Z. Ong, Jenny G. Low, Eng Eong Ooi

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Aviremic organ transplant dengue virus transmission - A case report von Sim, Jean X Y, Gan, Esther S, Tan, Hwee C, Choy, Milly M, Wong, Hei M, Tan, Ban H, Kee, Terence, Ho, Quan Y, Thangaraju, Sobhana, Lin, Raymond T P, Ooi, Eng E, Low, Jenny G-H

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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer von Liu, Xiaoguang, Olszewski, Kellen, Zhang, Yilei, Lim, Esther W., Shi, Jiejun, Zhang, Xiaoshan, Zhang, Jie, Lee, Hyemin, Koppula, Pranavi, Lei, Guang, Zhuang, Li, You, M. James, Fang, Bingliang, Li, Wei, Metallo, Christian M., Poyurovsky, Masha V., Gan, Boyi

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Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal von Xie, Stephanie Z., Garcia-Prat, Laura, Voisin, Veronique, Ferrari, Robin, Gan, Olga I., Wagenblast, Elvin, Kaufmann, Kerstin B., Zeng, Andy G.X., Takayanagi, Shin-ichiro, Patel, Ishita, Lee, Esther K., Jargstorf, Joseph, Holmes, Gareth, Romm, Guy, Pan, Kristele, Shoong, Michelle, Vedi, Aditi, Luberto, Chiara, Minden, Mark D., Bader, Gary D., Laurenti, Elisa, Dick, John E.

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Effect of Ezetimibe on Hepatic Fat, Inflammatory Markers, and Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Subjects on a Weight Loss Diet von Chan, Dick C, Watts, Gerald F, Gan, Seng Khee, Ooi, Esther M.M, Barrett, P. Hugh R

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