GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates von Breen, Danna M., Kim, Hanna, Bennett, Donald, Calle, Roberto A., Collins, Susie, Esquejo, Ryan M., He, Tao, Joaquim, Stephanie, Joyce, Alison, Lambert, Matthew, Lin, Laura, Pettersen, Betty, Qiao, Shuxi, Rossulek, Michelle, Weber, Gregory, Wu, Zhidan, Zhang, Bei B., Birnbaum, Morris J.

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Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial von Saxena, Aditi R., Gorman, Donal N., Esquejo, Ryan M., Bergman, Arthur, Chidsey, Kristin, Buckeridge, Clare, Griffith, David A., Kim, Albert M.

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SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation von Roqueta-Rivera, Manuel, Esquejo, Ryan M., Phelan, Peter E., Sandor, Katalin, Daniel, Bence, Foufelle, Fabienne, Ding, Jun, Li, Xiaoman, Khorasanizadeh, Sepideh, Osborne, Timothy F.

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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis von Miao, Ji, Ling, Alisha V., Manthena, Praveen V., Gearing, Mary E., Graham, Mark J., Crooke, Rosanne M., Croce, Kevin J., Esquejo, Ryan M., Clish, Clary B., Vicent, David, Biddinger, Sudha B.

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An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis von Jeon, Tae-Il, Esquejo, Ryan M., Roqueta-Rivera, Manuel, Phelan, Peter E., Moon, Young-Ah, Govindarajan, Subramaniam S., Esau, Christine C., Osborne, Timothy F.

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum von Esquejo, Ryan M., Roqueta-Rivera, Manuel, Shao, Wei, Phelan, Peter E., Seneviratne, Uthpala, am Ende, Christopher W., Hershberger, Paul M., Machamer, Carolyn E., Espenshade, Peter J., Osborne, Timothy F.

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Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity von Flaherty, Stephen E., Bezy, Olivier, Zheng, Wei, Yan, Dong, Li, Xiangping, Jagarlapudi, Srinath, Albuquerque, Bina, Esquejo, Ryan M., Peloquin, Matthew, Semache, Meriem, Mancini, Arturo, Kang, Liya, Drujan, Doreen, Breitkopf, Susanne B., Griffin, John D., Jean Beltran, Pierre M., Xue, Liang, Stansfield, John, Pashos, Evanthia, Shakey, Quazi, Pehmøller, Christian, Monetti, Mara, Birnbaum, Morris J., Fortin, Jean-Philippe, Wu, Zhidan

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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice von Cokorinos, Emily C., Delmore, Jake, Reyes, Allan R., Albuquerque, Bina, Kjøbsted, Rasmus, Jørgensen, Nicolas O., Tran, Jean-Luc, Jatkar, Aditi, Cialdea, Katherine, Esquejo, Ryan M., Meissen, John, Calabrese, Matthew F., Cordes, Jason, Moccia, Robert, Tess, David, Salatto, Christopher T., Coskran, Timothy M., Opsahl, Alan C., Flynn, Declan, Blatnik, Matthew, Li, Wenlin, Kindt, Erick, Foretz, Marc, Viollet, Benoit, Ward, Jessica, Kurumbail, Ravi G., Kalgutkar, Amit S., Wojtaszewski, Jørgen F.P., Cameron, Kimberly O., Miller, Russell A.

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Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model von Bernardo, Barbara, Joaquim, Stephanie, Garren, Jeonifer, Boucher, Magalie, Houle, Christopher, LaCarubba, Brianna, Qiao, Shuxi, Wu, Zhidan, Esquejo, Ryan M., Peloquin, Matthew, Kim, Hanna, Breen, Danna M.

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AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism von Esquejo, Ryan M., Albuquerque, Bina, Sher, Anna, Blatnik, Matthew, Wald, Kyle, Peloquin, Matthew, Delmore, Jake, Kindt, Erick, Li, Wenlin, Young, Jamey D., Cameron, Kim, Miller, Russell A.

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Lipid-cell cycle nexus: SREBP regulates microRNAs targeting Fbxw7 von Esquejo, Ryan M, Jeon, Tae-Il, Osborne, Timothy F

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Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models von Esquejo, Ryan M., Salatto, Christopher T., Delmore, Jake, Albuquerque, Bina, Reyes, Allan, Shi, Yuji, Moccia, Rob, Cokorinos, Emily, Peloquin, Matthew, Monetti, Mara, Barricklow, Jason, Bollinger, Eliza, Smith, Brennan K., Day, Emily A., Nguyen, Chuong, Geoghegan, Kieran F., Kreeger, John M., Opsahl, Alan, Ward, Jessica, Kalgutkar, Amit S., Tess, David, Butler, Lynne, Shirai, Norimitsu, Osborne, Timothy F., Steinberg, Gregory R., Birnbaum, Morris J., Cameron, Kimberly O., Miller, Russell A.

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Abstract 3056: Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival von Breen, Danna M., Beaumont, Kevin, Bennett, Donald, Brosnan, Julia, Calle, Roberto, Chabot, Jeffrey R., Collins, Susie, Cunio, Teresa, Esquejo, Ryan M., Joaquim, Stephanie, Joyce, Alison, Kim, Hanna, Lin, Laura, Pettersen, Betty, Qiao, Shuxi, Rossulek, Michelle, Tierney, Brendan, Walters, Karen M., Weber, Gregory, Wu, Zhidan, Zhang, Bei B., Birnbaum, Morris J.

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Growth differentiation factor 15 (GDF-15) as a key regulator of cachexia induced by platinum-based chemotherapy von Breen, Danna, Beaumont, Kevin, Bennett, Donald, Brosnan, Julia, Calle, Roberto A, Chabot, Jeffrey, Collins, Susie, Esquejo, Ryan, Joaquim, Stephanie, Joyce, Alison, Kim, Hanna, Lin, Laura, Pettersen, Betty A, Qiao, Shuxi, Rossulek, Michelle I, Walters, Karen, Weber, Gregory, Wu, Zhidan, Zhang, Bei Betty, Birnbaum, Morris J

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Protein kinase A (PKA) interferes with the processing and activity of sterol regulatory element binding proteins (SREBPs) von Esquejo, Ryan Magadan, Phelan, Peter E., Roqueta‐Rivera, Manuel, Osborne, Timothy F.

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An SREBP Responsive micro-RNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis von Jeon, Tae-Il, Esquejo, Ryan M., Roqueta-Rivera, Manuel, Phelan, Peter E., Moon, Young-Ah, Govindarajan, Subramaniam S., Esau, Christine C., Osborne, Timothy F.

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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis von Miao, Ji, Ling, Alisha V, Manthena, Praveen V, Gearing, Mary E, Graham, Mark J, Crooke, Rosanne M, Croce, Kevin J, Esquejo, Ryan M, Clish, Clary B, Torrecilla, Esther, Vázquez, Gumersindo Fernández, Rubio, Miguel A, Cabrerizo, Lucio, Barabash, Ana, Pernaute, Andrés Sánchez, Torres, Antonio J, Vicent, David, Biddinger, Sudha B

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