Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells von Jones, Jessica E C, Esler, William P, Patel, Rushi, Lanba, Adhiraj, Vera, Nicholas B, Pfefferkorn, Jeffrey A, Vernochet, Cecile

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Metabolic Targets in Nonalcoholic Fatty Liver Disease von Esler, William P, Bence, Kendra K

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A Portrait of Alzheimer Secretases: New Features and Familiar Faces von Esler, William P., Wolfe, Michael S.

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The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes von Linden, Melissa A., Ross, Trenton T., Beebe, David A., Gorgoglione, Matthew F., Hamilton, Karyn L., Miller, Benjamin F., Braun, Barry, Esler, William P.

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Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction von Gutierrez, Jemy A., Liu, Wei, Perez, Sylvie, Xing, Gang, Sonnenberg, Gabriele, Kou, Kou, Blatnik, Matt, Allen, Richard, Weng, Yan, Vera, Nicholas B., Chidsey, Kristin, Bergman, Arthur, Somayaji, Veena, Crowley, Collin, Clasquin, Michelle F., Nigam, Anu, Fulham, Melissa A., Erion, Derek M., Ross, Trenton T., Esler, William P., Magee, Thomas V., Pfefferkorn, Jeffrey A., Bence, Kendra K., Birnbaum, Morris J., Tesz, Gregory J.

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Activity-Dependent Isolation of the Presenilin- γ-Secretase Complex Reveals Nicastrin and a γ Substrate von Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Ye, Wenjuan, Diehl, Thekla S., Selkoe, Dennis J., Wolfe, Michael S.

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Pharmacologic inhibition of lipogenesis for the treatment of NAFLD von Esler, William P., Cohen, David E.

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Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants von Sawant‐Basak, Aarti, Bergman, Arthur J., Mancuso, Jessica, Tripathy, Sakambari, Gosset, James R., Mendes da Costa, Laure, Esler, William P., Calle, Roberto A.

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Small-Molecule Ghrelin Receptor Antagonists Improve Glucose Tolerance, Suppress Appetite, and Promote Weight Loss von Esler, William P, Rudolph, Joachim, Claus, Thomas H, Tang, Weifeng, Barucci, Nicole, Brown, Su-Ellen, Bullock, William, Daly, Michelle, DeCarr, Lynn, Li, Yaxin, Milardo, Lucinda, Molstad, David, Zhu, Jian, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J

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Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1 von Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Diehl, Thekla S., Moore, Chad L., Tsai, Jui-Yi, Rahmati, Talat, Xia, Weiming, Selkoe, Dennis J., Wolfe, Michael S.

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Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity von Rudolph, Joachim, Esler, William P, O'Connor, Stephen, Coish, Philip D. G, Wickens, Philip L, Brands, Michael, Bierer, Donald E, Bloomquist, Brian T, Bondar, Georgiy, Chen, Libing, Chuang, Chih-Yuan, Claus, Thomas H, Fathi, Zahra, Fu, Wenlang, Khire, Uday R, Kristie, James A, Liu, Xiao-Gao, Lowe, Derek B, McClure, Andrea C, Michels, Martin, Ortiz, Astrid A, Ramsden, Philip D, Schoenleber, Robert W, Shelekhin, Tatiana E, Vakalopoulos, Alexandros, Tang, Weifeng, Wang, Lei, Yi, Lin, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J, Bullock, William H

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Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models von Jiménez de Oya, Nereida, Esler, William P., Huard, Kim, El-Kattan, Ayman F., Karamanlidis, Georgios, Blázquez, Ana-Belén, Ramos-Ibeas, Priscila, Escribano-Romero, Estela, Louloudes-Lázaro, Andrés, Casas, Josefina, Sobrino, Francisco, Hoehn, Kyle, James, David E., Gutiérrez-Adán, Alfonso, Saiz, Juan-Carlos, Martín-Acebes, Miguel A.

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ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials von Calle, Roberto A., Amin, Neeta B., Carvajal-Gonzalez, Santos, Ross, Trenton T., Bergman, Arthur, Aggarwal, Sudeepta, Crowley, Collin, Rinaldi, Anthony, Mancuso, Jessica, Aggarwal, Naresh, Somayaji, Veena, Inglot, Malgorzata, Tuthill, Theresa A., Kou, Kou, Boucher, Magalie, Tesz, Greg, Dullea, Robert, Bence, Kendra K., Kim, Albert M., Pfefferkorn, Jeffrey A., Esler, William P.

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Alzheimer's Disease Amyloid Propagation by a Template-Dependent Dock-Lock Mechanism von Esler, William P, Stimson, Evelyn R, Jennings, Joan M, Vinters, Harry V, Ghilardi, Joseph R, Lee, Jonathan P, Mantyh, Patrick W, Maggio, John E

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Fundamental high-pressure calibration from all-electron quantum Monte Carlo calculations von Esler, K P, Cohen, R E, Militzer, B, Kim, Jeongnim, Needs, R J, Towler, M D

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Fibrillar beta -Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo von Weldon, Derik T, Rogers, Scott D, Ghilardi, Joseph R, Finke, Matthew P, Cleary, James P, O'Hare, Eugene, Esler, William P, Maggio, John E, Mantyh, Patrick W

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A phase 2a, randomized, double‐blind, placebo‐controlled, three‐arm, parallel‐group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF‐06835919 in patien... von Saxena, Aditi R., Lyle, Stephanie‐An, Khavandi, Kaivan, Qiu, Ruolun, Whitlock, Mark, Esler, William P., Kim, Albert M.

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver‐Targeting Acetyl‐CoA Carboxylase Inhibitor (PF‐05221304): A Three‐Part Randomized Phase 1 Study von Bergman, Arthur, Carvajal‐Gonzalez, Santos, Tarabar, Sanela, Saxena, Aditi R., Esler, William P., Amin, Neeta B.

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Notch and the Amyloid Precursor Protein Are Cleaved by Similar γ-Secretase(s) von Kimberly, W. Taylor, Esler, William P, Ye, Wenjuan, Ostaszewski, Beth L, Gao, Jun, Diehl, Thekla, Selkoe, Dennis J, Wolfe, Michael S

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An efficient hybrid orbital representation for quantum Monte Carlo calculations von Luo, Ye, Esler, Kenneth P., Kent, Paul R. C., Shulenburger, Luke

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