APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids von Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun

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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation von Johnson, Erik C. B., Dammer, Eric B., Duong, Duc M., Ping, Lingyan, Zhou, Maotian, Yin, Luming, Higginbotham, Lenora A., Guajardo, Andrew, White, Bartholomew, Troncoso, Juan C., Thambisetty, Madhav, Montine, Thomas J., Lee, Edward B., Trojanowski, John Q., Beach, Thomas G., Reiman, Eric M., Haroutunian, Vahram, Wang, Minghui, Schadt, Eric, Zhang, Bin, Dickson, Dennis W., Ertekin-Taner, Nilüfer, Golde, Todd E., Petyuk, Vladislav A., De Jager, Philip L., Bennett, David A., Wingo, Thomas S., Rangaraju, Srikant, Hajjar, Ihab, Shulman, Joshua M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.

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Risk factors for severe COVID-19 differ by age for hospitalized adults von Molani, Sevda, Hernandez, Patricia V., Roper, Ryan T., Duvvuri, Venkata R., Baumgartner, Andrew M., Goldman, Jason D., Ertekin-Taner, Nilüfer, Funk, Cory C., Price, Nathan D., Rappaport, Noa, Hadlock, Jennifer J.

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Molecular estimation of neurodegeneration pseudotime in older brains von Mukherjee, Sumit, Heath, Laura, Preuss, Christoph, Jayadev, Suman, Garden, Gwenn A., Greenwood, Anna K., Sieberts, Solveig K., De Jager, Philip L., Ertekin-Taner, Nilüfer, Carter, Gregory W., Mangravite, Lara M., Logsdon, Benjamin A.

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Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue von Ma, Yiyi, Dammer, Eric B., Felsky, Daniel, Duong, Duc M., Klein, Hans-Ulrich, White, Charles C., Zhou, Maotian, Logsdon, Benjamin A., McCabe, Cristin, Xu, Jishu, Wang, Minghui, Wingo, Thomas S., Lah, James J., Zhang, Bin, Schneider, Julie, Allen, Mariet, Wang, Xue, Ertekin-Taner, Nilüfer, Seyfried, Nicholas T., Levey, Allan I., Bennett, David A., De Jager, Philip L.

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[18F]AV‐1451 clustering of entorhinal and cortical uptake in Alzheimer's disease von Whitwell, Jennifer L., Graff‐Radford, Jonathan, Tosakulwong, Nirubol, Weigand, Stephen D., Machulda, Mary, Senjem, Matthew L., Schwarz, Christopher G., Spychalla, Anthony J., Jones, David T., Drubach, Daniel A., Knopman, David S., Boeve, Bradley F., Ertekin‐Taner, Nilüfer, Petersen, Ronald C., Lowe, Val J., Jack, Clifford R., Josephs, Keith A.

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Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease von Whitwell, Jennifer L., Graff-Radford, Jonathan, Tosakulwong, Nirubol, Weigand, Stephen D., Machulda, Mary M., Senjem, Matthew L., Spychalla, Anthony J., Vemuri, Prashanthi, Jones, David T., Drubach, Daniel A., Knopman, David S., Boeve, Bradley F., Ertekin-Taner, Nilüfer, Petersen, Ronald C., Lowe, Val J., Jack, Clifford R., Josephs, Keith A.

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Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations von Patel, Tulsi, Carnwath, Troy P., Wang, Xue, Allen, Mariet, Lincoln, Sarah J., Lewis‐Tuffin, Laura J., Quicksall, Zachary S., Lin, Shu, Tutor‐New, Frederick Q., Ho, Charlotte C.G., Min, Yuhao, Malphrus, Kimberly G., Nguyen, Thuy T., Martin, Elizabeth, Garcia, Cesar A., Alkharboosh, Rawan M., Grewal, Sanjeet, Chaichana, Kaisorn, Wharen, Robert, Guerrero‐Cazares, Hugo, Quinones‐Hinojosa, Alfredo, Ertekin‐Taner, Nilüfer

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The landscape of metabolic brain alterations in Alzheimer's disease von Batra, Richa, Arnold, Matthias, Wörheide, Maria A., Allen, Mariet, Wang, Xue, Blach, Colette, Levey, Allan I., Seyfried, Nicholas T., Ertekin‐Taner, Nilüfer, Bennett, David A., Kastenmüller, Gabi, Kaddurah‐Daouk, Rima F., Krumsiek, Jan

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A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech von Josephs, Keith A., Duffy, Joseph R., Clark, Heather M., Utianski, Rene L., Strand, Edythe A., Machulda, Mary M., Botha, Hugo, Martin, Peter R., Pham, Nha Trang Thu, Stierwalt, Julie, Ali, Farwa, Buciuc, Marina, Baker, Matthew, Fernandez De Castro, Cristhoper H., Spychalla, Anthony J., Schwarz, Christopher G., Reid, Robert I., Senjem, Matthew L., Jack, Clifford R., Lowe, Val J., Bigio, Eileen H., Reichard, Ross R., Polley, Eric. J., Ertekin-Taner, Nilufer, Rademakers, Rosa, DeTure, Michael A., Ross, Owen A., Dickson, Dennis W., Whitwell, Jennifer L.

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Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology von Miller, Brendan, Kim, Su‐Jeong, Cao, Kevin, Mehta, Hemal H., Thumaty, Neehar, Kumagai, Hiroshi, Iida, Tomomitsu, McGill, Cassandra, Pike, Christian J., Nurmakova, Kamila, Levine, Zachary A., Sullivan, Patrick M., Yen, Kelvin, Ertekin‐Taner, Nilüfer, Atzmon, Gil, Barzilai, Nir, Cohen, Pinchas

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Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids von Zhao, Jing, Lu, Wenyan, Ren, Yingxue, Fu, Yuan, Martens, Yuka A., Shue, Francis, Davis, Mary D., Wang, Xue, Chen, Kai, Li, Fuyao, Liu, Chia-Chen, Graff-Radford, Neill R., Wszolek, Zbigniew K., Younkin, Steven G., Brafman, David A., Ertekin-Taner, Nilüfer, Asmann, Yan W., Dickson, Dennis W., Xu, Ziying, Pan, Meixia, Han, Xianlin, Kanekiyo, Takahisa, Bu, Guojun

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TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia von Nicholson, Alexandra M., Finch, NiCole A., Wojtas, Aleksandra, Baker, Matt C., Perkerson, Ralph B., Castanedes‐Casey, Monica, Rousseau, Linda, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Hsiung, Ging‐Yuek R., Mackenzie, Ian R., Finger, Elizabeth, Boeve, Bradley F., Ertekin‐Taner, Nilüfer, Graff‐Radford, Neill R., Dickson, Dennis W., Rademakers, Rosa

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Whole genome sequencing–based copy number variations reveal novel pathways and targets in Alzheimer's disease von Ming, Chen, Wang, Minghui, Wang, Qian, Neff, Ryan, Wang, Erming, Shen, Qi, Reddy, Joseph S., Wang, Xue, Allen, Mariet, Ertekin‐Taner, Nilüfer, De Jager, Philip L., Bennett, David A., Haroutunian, Vahram, Schadt, Eric, Zhang, Bin

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Clinicopathological associations of hemispheric dominance in primary progressive apraxia of speech von Robinson, Carling G., Duffy, Joseph R., Clark, Heather A., Utianski, Rene L., Machulda, Mary M., Botha, Hugo, Singh, Neha Atulkumar, Pham, Nha Trang Thu, Ertekin‐Taner, Nilufer, Dickson, Dennis W., Lowe, Val J., Whitwell, Jennifer L., Josephs, Keith A.

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Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology von Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter

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TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease von Chakrabarty, Paramita, Li, Andrew, Ladd, Thomas B, Strickland, Michael R, Koller, Emily J, Burgess, Jeremy D, Funk, Cory C, Cruz, Pedro E, Allen, Mariet, Yaroshenko, Mariya, Wang, Xue, Younkin, Curtis, Reddy, Joseph, Lohrer, Benjamin, Mehrke, Leonie, Moore, Brenda D, Liu, Xuefei, Ceballos-Diaz, Carolina, Rosario, Awilda M, Medway, Christopher, Janus, Christopher, Li, Hong-Dong, Dickson, Dennis W, Giasson, Benoit I, Price, Nathan D, Younkin, Steven G, Ertekin-Taner, Nilüfer, Golde, Todd E

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Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease von Li, Hong‐Dong, Funk, Cory C., McFarland, Karen, Dammer, Eric B., Allen, Mariet, Carrasquillo, Minerva M., Levites, Yona, Chakrabarty, Paramita, Burgess, Jeremy D., Wang, Xue, Dickson, Dennis, Seyfried, Nicholas T., Duong, Duc M., Lah, James J., Younkin, Steven G., Levey, Allan I., Omenn, Gilbert S., Ertekin‐Taner, Nilüfer, Golde, Todd E., Price, Nathan D.

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Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments von Caride, Ariel, Jang, Jin Sung, Shi, Geng-Xian, Lenz, Sam, Zhong, Jian, Kim, Kwan Hyun, Allen, Mariet, Robertson, Keith D, Farrugia, Gianrico, Ordog, Tamas, Ertekin-Taner, Nilüfer, Lee, Jeong-Heon

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Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology von Nho, Kwangsik, Nudelman, Kelly, Allen, Mariet, Hodges, Angela, Kim, Sungeun, Risacher, Shannon L., Apostolova, Liana G., Lin, Kuang, Lunnon, Katie, Wang, Xue, Burgess, Jeremy D., Ertekin‐Taner, Nilüfer, Petersen, Ronald C., Wang, Lisu, Qi, Zhenhao, He, Aiqing, Neuhaus, Isaac, Patel, Vishal, Foroud, Tatiana, Faber, Kelley M., Lovestone, Simon, Simmons, Andrew, Weiner, Michael W., Saykin, Andrew J.

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