Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography von Orth, Peter, Xiao, Li, Hernandez, Lorraine D., Reichert, Paul, Sheth, Payal R., Beaumont, Maribel, Yang, Xiaoyu, Murgolo, Nicholas, Ermakov, Grigori, DiNunzio, Edward, Racine, Fred, Karczewski, Jerzy, Secore, Susan, Ingram, Richard N., Mayhood, Todd, Strickland, Corey, Therien, Alex G.

Volltext

Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells von Sukumar, Selvakumar, Wilson, Douglas C, Yu, Ying, Wong, Jerelyn, Naravula, Saraswathi, Ermakov, Grigori, Riener, Romina, Bhagwat, Bhagyashree, Necheva, Antoaneta S, Grein, Jeff, Churakova, Tatyana, Mangadu, Ruban, Georgiev, Peter, Manfra, Denise, Pinheiro, Elaine M, Sriram, Venkataraman, Bailey, Wendy J, Herzyk, Danuta, McClanahan, Terrill K, Willingham, Aarron, Beebe, Amy M, Sadekova, Svetlana

Volltext

Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α von Mak, Victor W., Patel, Akash M., Yen, Rose, Hanisak, Jennifer, Lim, Yeon-Hee, Bao, Jianming, Zheng, Rong, Seganish, W. Michael, Yu, Yang, Healy, David R., Ogawa, Aimie, Ren, Zhao, Soriano, Aileen, Ermakov, Grigori P., Beaumont, Maribel, Metwally, Essam, Cheng, Alan C., Verras, Andreas, Fischmann, Thierry, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Barker, John, Rearden, Paul, Greshock, Thomas J.

Volltext

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab von Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.

Volltext

Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies von Dang, Xibei, Guelen, Lars, Lutje Hulsik, David, Ermakov, Grigori, Hsieh, Edward J, Kreijtz, Joost, Stammen-Vogelzangs, Judith, Lodewijks, Imke, Bertens, Astrid, Bramer, Arne, Guadagnoli, Marco, Nazabal, Alexis, van Elsas, Andrea, Fischmann, Thierry, Juan, Veronica, Beebe, Amy, Beaumont, Maribel, van Eenennaam, Hans

Volltext

Structural insights into selective small molecule activation of PKG1α von Metwally, Essam, Mak, Victor, Soriano, Aileen, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Ermakov, Grigori, Beaumont, Maribel, Tawa, Paul, Barker, John J., Yen, Rose, Patel, Akash, Lim, Yeon-Hee, Healy, David, Hanisak, Jennifer, Cheng, Alan C., Greshock, Tom, Fischmann, Thierry O.

Volltext

Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection von Beaumont, Maribel, Tomazela, Daniela, Hodges, Douglas, Ermakov, Grigori, Hsieh, Edward, Figueroa, Isabel, So, On-Yee, Song, Yaoli, Ma, Huiping, Antonenko, Svetlana, Mengesha, Wondwessen, Zhang, Yi Wei, Zhang, Shuli, Hseih, SuChun, Ayanoglu, Gulesi, Du, Xiaoyan, Rimmer, Eric, Judo, Michael, Vives, Franklin, Yearley, Jennifer H., Moon, Christina, Manibusan, Anthony, Knudsen, Nick, Beck, Andy, Bresson, Damien, Gately, Dennis, Neupane, Divas, Escandón, Enrique

Volltext

Site-Specific Antibody Conjugation Using Modified Bisected N‑Glycans: Method Development and Potential toward Tunable Effector Function von Hsu, Yen-Pang, Nourzaie, Omar, Tocher, Ariel E., Nerella, Kavitha, Ermakov, Grigori, Jung, Jiwon, Fowler, Alexandra, Wu, Peidong, Ayesa, Umme, Willingham, Aarron, Beaumont, Maribel, Ingale, Sampat

Volltext

Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo von Yang, Xiaoyu, Wang, Fengqiang, Zhang, Ying, Wang, Larry, Antonenko, Svetlana, Zhang, Shuli, Zhang, Yi Wei, Tabrizifard, Mohammad, Ermakov, Grigori, Wiswell, Derek, Beaumont, Maribel, Liu, Liming, Richardson, Daisy, Shameem, Mohammed, Ambrogelly, Alexandre

Volltext

Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors von Carrington, Paul E, Gately, Dennis, Manibusan, Anthony, Orvieto, Federica, Bianchi, Elisabetta, Ermakov, Grigori, Knudsen, Nick, Garbaccio, Robert M, Seghezzi, Wolfgang

Volltext bestellen

Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies von Dang, Xibei, Guelen, Lars, Lutje Hulsik, David, Ermakov, Grigori, Hsieh, Edward J., Kreijtz, Joost, Stammen-Vogelzangs, Judith, Lodewijks, Imke, Bertens, Astrid, Bramer, Arne, Guadagnoli, Marco, Nazabal, Alexis, van Elsas, Andrea, Fischmann, Thierry, Juan, Veronica, Beebe, Amy, Beaumont, Maribel, van Eenennaam, Hans

Volltext

ANTI-GITR ANTIBODIES von HODGES, Douglas, J, ERMAKOV, Grigori P, PRESTA, Leonard, G, SCHEBYE, Xiao Min

Volltext bestellen

ANTIBODY PEPTIDE CONJUGATES THAT HAVE AGONIST ACTIVITY AT BOTH THE GLUCAGON AND GLUCAGON-LIKE PEPTIDE 1 RECEPTORS von Carrington, Paul E, Gately, Dennis, Manibusan, Anthony, Orvieto, Federica, Bianchi, Elisabetta, Ermakov, Grigori, Knudsen, Nick, Garbaccio, Robert M, Seghezzi, Wolfgang

Volltext bestellen

Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors von Gately, Dennis, Manibusan, Anthony, Orvieto, Federica, Carrington, Paul, Bianchi, Elisabetta, Ermakov, Grigori, Knudsen, Nick, Garbaccio, Robert M, Seghezzi, Wolfgang

Volltext bestellen

Anti-GITR antibodies von Hodges, Douglas J, Schebye, Xiao Min, Presta, Leonard G, Ermakov, Grigori P

Volltext bestellen

ANTIBODY PEPTIDE CONJUGATES THAT HAVE AGONIST ACTIVITY AT BOTH THE GLUCAGON AND GLUCAGON-LIKE PEPTIDE 1 RECEPTORS von BIANCHI, Elisabetta, GARBACCIO, Robert, M, GATELY, Dennis, CARRINGTON, Paul, E, ORVIETO, Federica, KNUDSEN, Nick, SEGHEZZI, Wolfgang, ERMAKOV, Grigori, MANIBUSAN, Anthony

Volltext bestellen

ANTIBODY PEPTIDE CONJUGATES THAT HAVE AGONIST ACTIVITY AT BOTH THE GLUCAGON AND GLUCAGON-LIKE PEPTIDE 1 RECEPTORS von Gately, Dennis, Manibusan, Anthony, Orvieto, Federica, Carrington, Paul, Bianchi, Elisabetta, Ermakov, Grigori, Knudsen, Nick, Garbaccio, Robert M, Seghezzi, Wolfgang

Volltext bestellen

ANTI-GITR ANTIBODIES von Hodges Douglas J, Presta Leonard G, Schebye Xiao Min, Ermakov Grigori P

Volltext bestellen

ANTIBODY PEPTIDE CONJUGATES THAT HAVE AGONIST ACTIVITY AT BOTH THE GLUCAGON AND GLUCAGON-LIKE PEPTIDE 1 RECEPTORS von BIANCHI, Elisabetta, GARBACCIO, Robert, M, GATELY, Dennis, CARRINGTON, Paul, E, ORVIETO, Federica, KNUDSEN, Nick, SEGHEZZI, Wolfgang, ERMAKOV, Grigori, MANIBUSAN, Anthony

Volltext bestellen

ANTI-GITR ANTIBODIES von ERMAKOV, Grigori P, HODGES, Douglas, PRESTA, Leonard, SCHEBYE, Xiao Min

Volltext bestellen