Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis von Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth M., Adams, Jerry M., Colman, Peter M.

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BECLIN1: Protein Structure, Function and Regulation von Tran, Sharon, Fairlie, W. Douglas, Lee, Erinna F.

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The Structural Biology of Bcl-xL von Lee, Erinna F., Fairlie, W. Douglas

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Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer von Fairlie, Walter Douglas, Lee, Erinna F

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Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers von Fairlie, W Douglas, Lee, Erinna F

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Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia von Glaser, Stefan P, Lee, Erinna F, Trounson, Evelyn, Bouillet, Philippe, Wei, Andrew, Fairlie, W Douglas, Izon, David J, Zuber, Johannes, Rappaport, Amy R, Herold, Marco J, Alexander, Warren S, Lowe, Scott W, Robb, Lorraine, Strasser, Andreas

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Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer von Lee, Erinna F, Fairlie, W Douglas

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ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types von Chüeh, Anderly C., Tse, Janson W.T., Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna F., Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

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Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo von Ji, Yanhao, Harris, Michael A, Newton, Lucas M, Harris, Tiffany J, Fairlie, W Douglas, Lee, Erinna F, Hawkins, Christine J

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Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins von Hockings, Colin, Alsop, Amber E., Fennell, Stephanie C., Lee, Erinna F., Fairlie, W. Douglas, Dewson, Grant, Kluck, Ruth M.

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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival von Lee, Erinna F., Harris, Tiffany J., Tran, Sharon, Evangelista, Marco, Arulananda, Surein, John, Thomas, Ramnac, Celeste, Hobbs, Chloe, Zhu, Haoran, Gunasingh, Gency, Segal, David, Behren, Andreas, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., Strasser, Andreas, Rohrbeck, Leona, Haass, Nikolas K., Herold, Marco J., Fairlie, W. Douglas

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Structural insights into the degradation of Mcl-1 induced by BH3 domains von Czabotar, Peter E, Lee, Erinna F, van Delft, Mark F, Day, Catherine L, Smith, Brian J, Huang, David C.S, Fairlie, W. Douglas, Hinds, Mark G, Colman, Peter M

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In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions von Atkin-Smith, Georgia K., Santavanond, Jascinta P., Light, Amanda, Rimes, Joel S., Samson, Andre L., Er, Jeremy, Liu, Joy, Johnson, Darryl N., Le Page, Mélanie, Rajasekhar, Pradeep, Yip, Raymond K. H., Geoghegan, Niall D., Rogers, Kelly L., Chang, Catherine, Bryant, Vanessa L., Margetts, Mai, Keightley, M. Cristina, Kilpatrick, Trevor J., Binder, Michele D., Tran, Sharon, Lee, Erinna F., Fairlie, Walter D., Ozkocak, Dilara C., Wei, Andrew H., Hawkins, Edwin D., Poon, Ivan K. H.

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role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins von Mérino, Delphine, Giam, Maybelline, Hughes, Peter D, Siggs, Owen M, Heger, Klaus, O'Reilly, Lorraine A, Adams, Jerry M, Strasser, Andreas, Lee, Erinna F, Fairlie, Walter D, Bouillet, Philippe

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MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib von Young, Adelaide I J, Law, Andrew M K, Castillo, Lesley, Chong, Sabrina, Cullen, Hayley D, Koehler, Martin, Herzog, Sebastian, Brummer, Tilman, Lee, Erinna F, Fairlie, Walter D, Lucas, Morghan C, Herrmann, David, Allam, Amr, Timpson, Paul, Watkins, D Neil, Millar, Ewan K A, O'Toole, Sandra A, Gallego-Ortega, David, Ormandy, Christopher J, Oakes, Samantha R

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Influenza A virus infection‐induced macroautophagy facilitates MHC class II‐restricted endogenous presentation of an immunodominant viral epitope von Deng, Jieru, Lu, Chunni, Liu, Chuanxin, Oveissi, Sara, Fairlie, W. Douglas, Lee, Erinna F., Bilsel, Pamuk, Puthalakath, Hamsa, Chen, Weisan

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α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells von Checco, James W, Lee, Erinna F, Evangelista, Marco, Sleebs, Nerida J, Rogers, Kelly, Pettikiriarachchi, Anne, Kershaw, Nadia J, Eddinger, Geoffrey A, Belair, David G, Wilson, Julia L, Eller, Chelcie H, Raines, Ronald T, Murphy, William L, Smith, Brian J, Gellman, Samuel H, Fairlie, W. Douglas

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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax von Fletcher, Jamie I, Meusburger, Sarina, Hawkins, Christine J, Riglar, David T, Lee, Erinna F, Fairlie, W. Douglas, Huang, David C.S, Adams, Jerry M

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High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL von Lee, Erinna F, Sadowsky, Jack D, Smith, Brian J, Czabotar, Peter E, Peterson-Kaufman, Kimberly J, Colman, Peter M, Gellman, Samuel H, Fairlie, W. Douglas

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Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 von Lee, Erinna F., Smith, Nicholas A., Soares da Costa, Tatiana P., Meftahi, Nastaran, Yao, Shenggen, Harris, Tiffany J., Tran, Sharon, Pettikiriarachchi, Anne, Perugini, Matthew A., Keizer, David W., Evangelista, Marco, Smith, Brian J., Fairlie, W. Douglas

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