Discovery, Synthesis, And Structure-Based Optimization of a Series of N‑(tert-Butyl)-2‑(N‑arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibi... von Jacobs, Jon, Grum-Tokars, Valerie, Zhou, Ya, Turlington, Mark, Saldanha, S. Adrian, Chase, Peter, Eggler, Aimee, Dawson, Eric S, Baez-Santos, Yahira M, Tomar, Sakshi, Mielech, Anna M, Baker, Susan C, Lindsley, Craig W, Hodder, Peter, Mesecar, Andrew, Stauffer, Shaun R

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Evaluation of the Biosynthetic Proposal for the Synthesis of Marineosins A and B von Aldrich, Leslie N, Dawson, Eric S, Lindsley, Craig W

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Streptomyces coelicolor A3(2) CYP102 Protein, a Novel Fatty Acid Hydroxylase Encoded as a Heme Domain without an N-Terminal Redox Partner von Lamb, David C, Lei, Li, Zhao, Bin, Yuan, Hang, Jackson, Colin J, Warrilow, Andrew G.S, Skaug, Tove, Dyson, Paul J, Dawson, Eric S, Kelly, Steven L, Hachey, David L, Waterman, Michael R

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Novel Benzodiazepine Photoaffinity Probe Stereoselectively Labels a Site Deep within the Membrane-Spanning Domain of the Cholecystokinin Receptor von Hadac, Elizabeth M, Dawson, Eric S, Darrow, James W, Sugg, Elizabeth E, Lybrand, Terry P, Miller, Laurence J

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2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency von Schulte, Michael L., Dawson, Eric S., Saleh, Sam A., Cuthbertson, Madison L., Manning, H. Charles

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Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening von Li, Jun, Smith, Jarrod A, Dawson, Eric S, Fu, Allie, Nickels, Michael L, Schulte, Michael L, Manning, H. Charles

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An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Discipl... von de Souza, Andrea, Bittker, Joshua A., Lahr, David L., Brudz, Steve, Chatwin, Simon, Oprea, Tudor I., Waller, Anna, Yang, Jeremy J., Southall, Noel, Guha, Rajarshi, Schürer, Stephan C., Vempati, Uma D., Southern, Mark R., Dawson, Eric S., Clemons, Paul A., Chung, Thomas D.Y.

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A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells von HIGHT, Matthew R, CHEUNG, Yiu-Yin, MANNING, H. Charles, NICKELS, Michael L, DAWSON, Eric S, PING ZHAO, SALEH, Samir, BUCK, Jason R, DEWEI TANG, WASHINGTON, M. Kay, COFFEY, Robert J

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Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel von Bhave, Gautam, Chauder, Brian A., Liu, Wen, Dawson, Eric S., Kadakia, Rishin, Nguyen, Thuy T., Lewis, L. Michelle, Meiler, Jens, Weaver, C. David, Satlin, Lisa M., Lindsley, Craig W., Denton, Jerod S.

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Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133 von Wang, Hao-Ran, Wu, Meng, Yu, Haibo, Long, Shunyou, Stevens, Amy, Engers, Darren W, Sackin, Henry, Daniels, J Scott, Dawson, Eric S, Hopkins, Corey R, Lindsley, Craig W, Li, Min, McManus, Owen B

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A Model for the Solution Structure of the Rod Arrestin Tetramer von Hanson, Susan M., Dawson, Eric S., Francis, Derek J., Van Eps, Ned, Klug, Candice S., Hubbell, Wayne L., Meiler, Jens, Gurevich, Vsevolod V.

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Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies von Kaufmann, Kristian W., Dawson, Eric S., Henry, L. Keith, Field, Julie R., Blakely, Randy D., Meiler, Jens

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A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport von Henry, L. Keith, Iwamoto, Hideki, Field, Julie R., Kaufmann, Kristian, Dawson, Eric S., Jacobs, Miriam T., Adams, Chelsea, Felts, Bruce, Zdravkovic, Igor, Armstrong, Vanessa, Combs, Steven, Solis, Ernesto, Rudnick, Gary, Noskov, Sergei Y., DeFelice, Louis J., Meiler, Jens, Blakely, Randy D.

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Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M 1 Receptor Function in the Central Nervous System von Lebois, Evan P, Bridges, Thomas M, Lewis, L. Michelle, Dawson, Eric S, Kane, Alexander S., Xiang, Zixiu, Jadhav, Satyawan B, Yin, Huiyong, Kennedy, J. Phillip, Meiler, Jens, Niswender, Colleen M., Jones, Carrie K, Conn, P Jeffrey, Weaver, C David, Lindsley, Craig W

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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Dise... von Xiang, Zixiu, Thompson, Analisa D, Brogan, John T, Schulte, Michael L, Melancon, Bruce J, Mi, Debbie, Lewis, L. Michelle, Zou, Bende, Yang, Liya, Morrison, Ryan, Santomango, Tammy, Byers, Frank, Brewer, Katrina, Aldrich, Jonathan S, Yu, Haibo, Dawson, Eric S, Li, Min, McManus, Owen, Jones, Carrie K, Daniels, J. Scott, Hopkins, Corey R, Xie, Ximin Simon, Conn, P. Jeffrey, Weaver, C. David, Lindsley, Craig W

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Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer von Harikumar, Kaleeckal G, Pinon, Delia I, Wessels, William S, Dawson, Eric S, Lybrand, Terry P, Prendergast, Franklyn G, Miller, Laurence J

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Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway von Theriault, Jimmy R., Felts, Andrew S., Bates, Brittney S., Perez, Jose R., Palmer, Michelle, Gilbert, Shawn R., Dawson, Eric S., Engers, Julie L., Lindsley, Craig W., Emmitte, Kyle A.

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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu5): From an Artificial Neural Networ... von Mueller, Ralf, Dawson, Eric S, Meiler, Jens, Rodriguez, Alice L, Chauder, Brian A, Bates, Brittney S, Felts, Andrew S, Lamb, Jeffrey P, Menon, Usha N, Jadhav, Sataywan B, Kane, Alexander S, Jones, Carrie K, Gregory, Karen J, Niswender, Colleen M, Conn, P. Jeffrey, Olsen, Christopher M, Winder, Danny G, Emmitte, Kyle A, Lindsley, Craig W

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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Netwo... von Mueller, Ralf, Dawson, Eric S., Meiler, Jens, Rodriguez, Alice L., Chauder, Brian A., Bates, Brittney S., Felts, Andrew S., Lamb, Jeffrey P., Menon, Usha N., Jadhav, Sataywan B., Kane, Alexander S., Jones, Carrie K., Gregory, Karen J., Niswender, Colleen M., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A., Lindsley, Craig W.

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Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold von Rodriguez, Alice L., Zhou, Ya, Williams, Richard, David Weaver, C., Vinson, Paige N., Dawson, Eric S., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M., Macdonald, Gregor J., Scott Daniels, J., Niswender, Colleen M., Jones, Carrie K., Jeffrey Conn, P., Lindsley, Craig W., Stauffer, Shaun R.

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