Anaerobic fungi in the tortoise alimentary tract illuminate early stages of host-fungal symbiosis and Neocallimastigomycota evolution von Pratt, Carrie J., Meili, Casey H., Jones, Adrienne L., Jackson, Darian K., England, Emma E., Wang, Yan, Hartson, Steve, Rogers, Janet, Elshahed, Mostafa S., Youssef, Noha H.

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Evaluating the impact of redox potential on the growth capacity of anaerobic gut fungi von England, Emma E, Pratt, Carrie J, Elshahed, Mostafa S, Youssef, Noha H

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Clinical features and management of human monkeypox: a retrospective observational study in the UK von Adler, Hugh, Hine, Paul, Snell, Luke B, Osborne, Jane C, Rampling, Tommy, Beadsworth, Mike BJ, Dunning, Jake, Hunter, Ewan R, Jacobs, Michael, Khoo, Saye H, Porter, David, Porter, Robert J, Ratcliffe, Libuše, Schmid, Matthias L, Tunbridge, Anne J, Wingfield, Tom, Price, Nicholas M, Abouyannis, Mike, Al-Balushi, Asma, Aston, Stephen, Ball, Robert, Blanchard, Thomas J, Davies, Geraint, Gillespie, Angela, Hicks, Scott R, Hoyle, Marie-Claire, Ilozue, Chinenye, Mair, Luke, Marshall, Suzanne, Neary, Anne, Nsutebu, Emmanuel, Ryan, Hannah, Turtle, Lance, van Aartsen, Jon, Walker, Naomi F, Woolley, Stephen, Chawla, Anu, Smielewska, Anna, Benson, Cathryn, Brindley, Cheryl, Das, Urmi, Eyton-Chong, Chin K, Gnanalingham, Claire, Larru, Beatriz, McBride, Joanna, Oliver, Claire, Paul, Princy, Riordan, Andrew, Abrahamsen, Jennifer, Athan, Breda, Bhagani, Sanjay, Brown, Colin S, Carpenter, Oliver, Cropley, Ian, Hopkins, Susan, Joyce, Jessica, Lamb, Lucy, Lyons, Adrian, Mahungu, Tabitha, Mepham, Stephen, Mukwaira, Edina, Rodger, Alison, Williams, Alan, Allen, Denise, Dixon, Jill, Evans, Adam, McNicholas, Pauline, Price, D Ashley, Schwab, Uli, Ward, Margaret, Emonts, Marieke, Owens, Stephen, Douthwaite, Sam T, Goodman, Anna, MacMahon, Eithne, Nebbia, Gaia, Parsons, Joseph, Sullivan, Tadgh, Taj, Usman, van Nipsen tot Pannerden, Claire, Winslow, Helen, Zatyka, Ewa, Alozie-Otuka, Ekene, Beviz, Csaba, Ceesay, Yusupha, Gargee, Latchmin, Mitchell, Hannah, Tabios, Federico, Wigglesworth, Neil, Brooks, Tim, Dryden, Matthew, Furneaux, Jenna, Truelove, Elizabeth, Warrell, Clare E, Firth, Richard, Hobson, Gemma, Johnson, Christopher, Dewynter, Alison, Spence, Oliver, Hruby, Dennis E

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A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage von Zou, Xueqing, Koh, Gene Ching Chiek, Nanda, Arjun Scott, Degasperi, Andrea, Urgo, Katie, Roumeliotis, Theodoros I, Agu, Chukwuma A, Badja, Cherif, Momen, Sophie, Young, Jamie, Amarante, Tauanne Dias, Side, Lucy, Brice, Glen, Perez-Alonso, Vanesa, Rueda, Daniel, Gomez, Celine, Bushell, Wendy, Harris, Rebecca, Choudhary, Jyoti S, Jiricny, Josef, Skarnes, William C, Nik-Zainal, Serena

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Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease von Claes, Christel, Danhash, Emma Pascal, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, England, Whitney E, Lim, Tau En, Hidalgo, Jorge Luis Silva, Spitale, Robert C, Davtyan, Hayk, Blurton-Jones, Mathew

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Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma von Jones, Christine L., Degasperi, Andrea, Grandi, Vieri, Amarante, Tauanne D., Mitchell, Tracey J., Nik-Zainal, Serena, Whittaker, Sean J.

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Presence of oxygen and mitochondria in skeletal muscle early postmortem von England, Eric M., Matarneh, Sulaiman K., Mitacek, Rachel M., Abraham, Anupam, Ramanathan, Ranjith, Wicks, Jordan C., Shi, Hao, Scheffler, Tracy L., Oliver, Emily M., Helm, Emma T., Gerrard, David E.

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An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy von Pagnamenta, Alistair T, Kaiyrzhanov, Rauan, Zou, Yaqun, Da'as, Sahar I, Maroofian, Reza, Donkervoort, Sandra, Dominik, Natalia, Lauffer, Marlen, Ferla, Matteo P, Orioli, Andrea, Giess, Adam, Tucci, Arianna, Beetz, Christian, Sedghi, Maryam, Ansari, Behnaz, Barresi, Rita, Basiri, Keivan, Cortese, Andrea, Elgar, Greg, Fernandez-Garcia, Miguel A, Yip, Janice, Foley, A Reghan, Gutowski, Nicholas, Jungbluth, Heinz, Lassche, Saskia, Lavin, Tim, Marcelis, Carlo, Marks, Peter, Marini-Bettolo, Chiara, Medne, Livija, Moslemi, Ali-Reza, Sarkozy, Anna, Reilly, Mary M, Muntoni, Francesco, Millan, Francisca, Muraresku, Colleen C, Need, Anna C, Nemeth, Andrea H, Neuhaus, Sarah B, Norwood, Fiona, O'Donnell, Marie, O'Driscoll, Mary, Rankin, Julia, Yum, Sabrina W, Zolkipli-Cunningham, Zarazuela, Brusius, Isabell, Wunderlich, Gilbert, Karakaya, Mert, Wirth, Brunhilde, Fakhro, Khalid A, Tajsharghi, Homa, Bönnemann, Carsten G, Taylor, Jenny C, Houlden, Henry

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Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study von Ibañez, Kristina, Polke, James, Hagelstrom, R Tanner, Dolzhenko, Egor, Pasko, Dorota, Thomas, Ellen Rachel Amy, Smith, Katherine R, McDonagh, Ellen M, Polychronopoulos, Dimitris, Chan, Georgia, Davison, James E, Festenstein, Richard, Fratta, Pietro, Giunti, Paola, Howard, Robin, Venkata, Laxmi, Laurá, Matilde, Morris, Huw, Robinson, Robert, Rosser, Elisabeth, Faravelli, Francesca, Schrag, Anette, Schott, Jonathan M, Wood, Nicholas W, Bourn, David, Eggleton, Kelly, Twiss, Philip, Almheiri, Ghareesa, Sheikh, Isabella, Vandrovcova, Jana, Brittain, Helen, Baple, Emma, Moutsianas, Loukas, Deshpande, Viraj, Perry, Denise L, Ajay, Subramanian S., Rajan, Vani, Oprych, Kathryn, Chinnery, Patrick F, Wilson, Gill, Ellard, Sian, Temple, I Karen, McMullan, Dom, Naresh, Kikkeri, Flinter, Frances A, Taylor, Jenny C, Greenhalgh, Lynn, Newman, William, Brennan, Paul, Sayer, John A, Raymond, F Lucy, Deans, Zandra C, Hill, Sue, Fowler, Tom, Scott, Richard H, Chinnery, Patrick F, Rendon, Augusto, Eberle, Michael A, Taft, Ryan J, Arumugam, Prabhu, Bleda, Marta, Boardman-Pretty, Freya, Boissiere, Jeanne M., Devereau, Andrew, Elgar, Greg, Foulger, Rebecca E., Furió-Tarí, Pedro, Hackett, Joanne, Hamblin, Angela, Holman, James, Hubbard, Tim J.P., Jones, Louise J., Kayikci, Melis, Lawson, Kay, Leigh, Sarah E.A., Leong, Ivonne U.S., Maleady-Crowe, Fiona, Mason, Joanne, Mueller, Michael, Murugaesu, Nirupa, Odhams, Chris A., Perez-Gil, Daniel, Pullinger, John, Rahim, Tahrima, Riesgo-Ferreiro, Pablo, Ryten, Mina, Savage, Kevin, Sawant, Kushmita, Sieghart, Alexander, Smedley, Damian, Sosinsky, Alona, Spooner, William, Stevens, Helen E., Stuckey, Alexander, Sultana, Razvan, Tregidgo, Carolyn, Walsh, Emma, Watters, Sarah A., Williams, Eleanor, Zarowiecki, Magdalena

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Human and mouse essentiality screens as a resource for disease gene discovery von Cacheiro, Pilar, Muñoz-Fuentes, Violeta, Murray, Stephen A., Dickinson, Mary E., Bucan, Maja, Nutter, Lauryl M. J., Peterson, Kevin A., Haselimashhadi, Hamed, Flenniken, Ann M., Morgan, Hugh, Westerberg, Henrik, Konopka, Tomasz, Hsu, Chih-Wei, Christiansen, Audrey, Lanza, Denise G., Beaudet, Arthur L., Heaney, Jason D., Fuchs, Helmut, Gailus-Durner, Valerie, Sorg, Tania, Prochazka, Jan, Novosadova, Vendula, Lelliott, Christopher J., Wardle-Jones, Hannah, Wells, Sara, Teboul, Lydia, Cater, Heather, Stewart, Michelle, Hough, Tertius, Wurst, Wolfgang, Sedlacek, Radislav, Adams, David J., Seavitt, John R., Tocchini-Valentini, Glauco, Mammano, Fabio, Braun, Robert E., McKerlie, Colin, Herault, Yann, de Angelis, Martin Hrabě, Mallon, Ann-Marie, Lloyd, K. C.  Kent, Brown, Steve D. M., Parkinson, Helen, Meehan, Terrence F., Smedley, Damian

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Dynamic changes in insulin-like growth factor binding protein expression occur between embryonic and early post-hatch development in broiler chickens von Vaccaro, Lauren A., Herring, Kyle, Wilson, Abigail, England, Emma, Smith, Addison L., Ellestad, Laura E.

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De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment von Rodger, Catherine, Flex, Elisabetta, Allison, Rachel J., Sanchis-Juan, Alba, Hasenahuer, Marcia A., Cecchetti, Serena, French, Courtney E., Edgar, James R., Carpentieri, Giovanna, Ciolfi, Andrea, Pantaleoni, Francesca, Bruselles, Alessandro, Onesimo, Roberta, Zampino, Giuseppe, Marcon, Francesca, Siniscalchi, Ester, Lees, Melissa, Krishnakumar, Deepa, McCann, Emma, Yosifova, Dragana, Jarvis, Joanna, Kruer, Michael C., Marks, Warren, Campbell, Jonathan, Allen, Louise E., Gustincich, Stefano, Raymond, F. Lucy, Tartaglia, Marco, Reid, Evan

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Invasion impacts and dynamics of a European‐wide introduced species von Haubrock, Phillip J., Ahmed, Danish A., Cuthbert, Ross N., Stubbington, Rachel, Domisch, Sami, Marquez, Jaime R. G., Beidas, Ayah, Amatulli, Giuseppe, Kiesel, Jens, Shen, Longzhu Q., Soto, Ismael, Angeler, David G., Bonada, Núria, Cañedo‐Argüelles, Miguel, Csabai, Zoltán, Datry, Thibault, Eyto, Elvira, Dohet, Alain, Drohan, Emma, England, Judy, Feio, Maria J., Forio, Marie A. E., Goethals, Peter, Graf, Wolfram, Heino, Jani, Hudgins, Emma J., Jähnig, Sonja C., Johnson, Richard K., Larrañaga, Aitor, Leitner, Patrick, L'Hoste, Lionel, Lizee, Marie‐Helene, Maire, Anthony, Rasmussen, Jes J., Schäfer, Ralf B., Schmidt‐Kloiber, Astrid, Vannevel, Rudy, Várbíró, Gábor, Wiberg‐Larsen, Peter, Haase, Peter

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Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis von Dewan, Ramita, Keagle, Pamela, Bacikova, Dagmar, Soltis, Anthony R., Kost, Jason, Colombrita, Claudia, Lewis, Elizabeth A., Pensato, Viviana, Castellotti, Barbara, McLaughlin, Russell L., Comi, Giacomo P., Ceroni, Mauro, Gagliardi, Stella, van Blitterswijk, Marka, Corrado, Lucia, Sorarù, Gianni, Williams, Kelly L., Morrison, Karen E., Veldink, Jan H., Brown, Robert H., Ambrose, John C., Brittain, H., Elgar, Greg, Halai, Dina, Holman, James E., Jackson, Rob, Leong, Ivonne U.S., Maleady-Crowe, Fiona, Mason, Joanne, Riesgo-Ferreiro, Pablo, Rogers, Tim, Watters, Sarah A., Arepalli, Sampath, Chiò, Adriano, Dunckley, Travis L., Faghri, Faraz, Feldman, Eva, Floeter, Mary Kay, Gerhard, Glenn, Jansson, Lilja, Kirby, Janine, Mora, Gabriele, Nalls, Mike A., Pulst, Stefan M., Ravits, John M., Renton, Alan E., Robberecht, Wim, Robey, Ian, Dols-Icardo, Oriol, Illán-Gala, Ignacio, Lleó, Alberto, Khoshnood, Behzad, Sorbi, Sandro, Pastor, Pau, Bigio, Eileen H., Black, Sandra E., Brunetti, Maura, Canosa, Antonio, Gan-Or, Ziv, Goate, Alison, Hupalo, Daniel, Infante, Jon, Kaufmann, Horacio, Kim, Ronald C., Krüger, Rejko, Logroscino, Giancarlo, Love, Seth, Mao, Qinwen, Masliah, Eliezer, Pletnikova, Olga, Reynolds, Regina H., Scherzer, Clemens R., Serrano, Geidy E., Xiromerisiou, Georgia, Phatnani, Hemali, Kwan, Justin, Broach, James R., Arcila-Londono, Ximena, Malaspina, Andrea, Thompson, Leslie M., Dardiotis, Efthimios, Chandran, Siddharthan, Butovsky, Oleg, Dubnau, Joshua, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Altschuler, Steven, Hu, Michele T.M., Leigh, P. Nigel, Massey, Luke A., Pavese, Nicola, Vaughan, Jenny, Rowe, James B., Ghidoni, Roberta, Ryten, Mina, Tanaka, Toshiko, Ferrucci, Luigi, Vonsattel, Jean Paul, Landers, John E.

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Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides von O'Brien, Darragh P., Jones, Hannah B.L., Guenther, Franziska, Murphy, Emma J., England, Katherine S., Vendrell, Iolanda, Anderson, Malcolm, Brennan, Paul E., Davis, John B., Pinto-Fernández, Adán, Turnbull, Andrew P., Kessler, Benedikt M.

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The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model von Claes, Christel, England, Whitney E., Danhash, Emma P., Kiani Shabestari, Sepideh, Jairaman, Amit, Chadarevian, Jean Paul, Hasselmann, Jonathan, Tsai, Andy P., Coburn, Morgan A., Sanchez, Jessica, Lim, Tau En, Hidalgo, Jorge L. S., Tu, Christina, Cahalan, Michael D., Lamb, Bruce T., Landreth, Gary E., Spitale, Robert C., Blurton‐Jones, Mathew, Davtyan, Hayk

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Detailed Analysis of ITPR1 Missense Variants Guides Diagnostics and Therapeutic Design von Tolonen, Jussi Pekka, Parolin Schnekenberg, Ricardo, McGowan, Simon, Sims, David, McEntagart, Meriel, Elmslie, Frances, Shears, Debbie, Stewart, Helen, Tofaris, George K., Dabir, Tabib, Morrison, Patrick J., Johnson, Diana, Hadjivassiliou, Marios, Ellard, Sian, Shaw‐Smith, Charles, Znaczko, Anna, Dixit, Abhijit, Suri, Mohnish, Sarkar, Ajoy, Harrison, Rachel E., Jones, Gabriela, Houlden, Henry, Ceravolo, Giorgia, Jarvis, Joanna, Williams, Jonathan, Shanks, Morag E., Clouston, Penny, Rankin, Julia, Blumkin, Lubov, Lerman‐Sagie, Tally, Ponger, Penina, Raskin, Salmo, Granath, Katariina, Uusimaa, Johanna, Conti, Hector, McCann, Emma, Joss, Shelagh, Blakes, Alexander J.M., Metcalfe, Kay, Kingston, Helen, Bertoli, Marta, Kneen, Rachel, Lynch, Sally Ann, Martínez Albaladejo, Inmaculada, Moore, Austen Peter, Jones, Wendy D., Becker, Esther B.E., Németh, Andrea H.

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Genomic loci susceptible to systematic sequencing bias in clinical whole genomes von Freeman, Timothy M, Wang, Dennis, Harris, Jason

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Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial von Perkins, Gavin D, Prof, Lall, Ranjit, PhD, Quinn, Tom, Prof, Deakin, Charles D, Prof, Cooke, Matthew W, Prof, Horton, Jessica, MSc, Lamb, Sarah E, Prof, Slowther, Anne-Marie, DPhil, Woollard, Malcolm, Prof, Carson, Andy, FRCGP, Smyth, Mike, MSc, Whitfield, Richard, BSc, Williams, Amanda, MA, Pocock, Helen, MSc, Black, John J M, FCEM, Wright, John, FCEM, Han, Kyee, FCEM, Gates, Simon, Prof

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Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia von Chen, Zhongbo, Tucci, Arianna, Cipriani, Valentina, Gustavsson, Emil K, Ibañez, Kristina, Reynolds, Regina H, Zhang, David, Vestito, Letizia, García, Alejandro Cisterna, Sethi, Siddharth, Brenton, Jonathan W, García-Ruiz, Sonia, Fairbrother-Browne, Aine, Gil-Martinez, Ana-Luisa, Wood, Nick, Hardy, John A, Smedley, Damian, Houlden, Henry, Botía, Juan, Ryten, Mina

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