Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients von Gruber, F X, Ernst, T, Porkka, K, Engh, R A, Mikkola, I, Maier, J, Lange, T, Hochhaus, A

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The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase... von von Bubnoff, N, Gorantla, S P, Engh, R A, Oliveira, T M, Thöne, S, Åberg, E, Peschel, C, Duyster, J

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Chalcone Derivatives Antagonize Interactions between the Human Oncoprotein MDM2 and p53 von Stoll, Raphael, Renner, Christian, Hansen, Silke, Palme, Stefan, Klein, Christian, Belling, Anja, Zeslawski, Wojciech, Kamionka, Mariusz, Rehm, Till, Mühlhahn, Peter, Schumacher, Ralf, Hesse, Friederike, Kaluza, Brigitte, Voelter, Wolfgang, Engh, Richard A, Holak, Tad A

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The refined 2.15 A X‐ray crystal structure of human liver cathepsin B: the structural basis for its specificity von Musil, D., Zucic, D., Turk, D., Engh, R.A., Mayr, I., Huber, R., Popovic, T., Turk, V., Towatari, T., Katunuma, N.

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Accurate bond and angle parameters for X-ray protein structure refinement von Engh, R. A., Huber, R.

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Conformational Variability of Chicken Cystatin: Comparison of Structures Determined by X-ray Diffraction and NMR Spectroscopy von Engh, Richard A., Dieckmann, Thorsten, Bode, Wolfram, Auerswald, Ennes A., Turk, Vito, Huber, Robert, Oschkinat, Hartmut

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Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for... von Engh, R A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D

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Crystal Structure of a Thermostable Type B DNA Polymerase from Thermococcus gorgonarius von Hopfner, Karl-Peter, Eichinger, Andreas, Engh, Richard A., Laue, Frank, Ankenbauer, Waltraud, Huber, Robert, Angerer, Bernhard

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Tetrahydro-isoquinoline-Based Factor Xa Inhibitors von Kucznierz, Ralf, Grams, Frank, Leinert, Herbert, Marzenell, Klaus, Engh, Richard A, von der Saal, Wolfgang

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Divining the serpin inhibition mechanism: a suicide substrate ‘springe’? von Engh, Richard A., Huber, Robert, Bode, Wolfram, Schulze, Andreas J.

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Structure of malonic acid‐based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data von Brandstetter, Hans, Engh, Richard A., Roedern, Erich Graf Von, Moroder, Luis, Huber, Robert, Bode, Wolfram, Grams, Frank

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In vitro folding and characterization of the p53 DNA binding domain von Klein, C., Hesse, F., Dehner, A., Engh, R. A., Schwaiger, M., Hansen, S.

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition von Brandstetter, H, Kühne, A, Bode, W, Huber, R, von der Saal, W, Wirthensohn, K, Engh, R A

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Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential von Prade, Lars, Engh, Richard A, Girod, Andreas, Kinzel, Volker, Huber, Robert, Bossemeyer, Dirk

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Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase A and Mutants von Breitenlechner, Christine B, Friebe, Walter-Gunar, Brunet, Emmanuel, Werner, Guido, Graul, Klaus, Thomas, Ulrike, Künkele, Klaus-Peter, Schäfer, Wolfgang, Gassel, Michael, Bossemeyer, Dirk, Huber, Robert, Engh, Richard A, Masjost, Birgit

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The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5 von Żesławski, Wojciech, Beisel, Hans-Georg, Kamionka, Mariusz, Kalus, Wenzel, Engh, Richard A., Huber, Robert, Lang, Kurt, Holak, Tad A.

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Structural aspects of serpin inhibition von Schulze, Andreas J., Huber, Robert, Bode, Wolfram, Engh, Richard A.

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Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding von Hopfner, Karl-Peter, Lang, Anja, Karcher, Annette, Sichler, Katrin, Kopetzki, Erhard, Brandstetter, Hans, Huber, Robert, Bode, Wolfram, Engh, Richard A

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High Thermostability and Lack of Cooperative DNA Binding Distinguish the p63 Core Domain from the Homologous Tumor Suppressor p53 von Klein, Christian, Georges, Guy, Künkele, Klaus-Peter, Huber, Robert, Engh, Richard A., Hansen, Silke

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Mutants of Protein Kinase A that Mimic the ATP-binding Site of Protein Kinase B (AKT) von Gaßel, Michael, Breitenlechner, Christine B., Rüger, Petra, Jucknischke, Ute, Schneider, Thorsten, Huber, Robert, Bossemeyer, Dirk, Engh, Richard A.

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