Targeting PI3K signalling in cancer: opportunities, challenges and limitations von Engelman, Jeffrey A

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Anchored multiplex PCR for targeted next-generation sequencing von Zheng, Zongli, Liebers, Matthew, Zhelyazkova, Boryana, Cao, Yi, Panditi, Divya, Lynch, Kerry D, Chen, Juxiang, Robinson, Hayley E, Shim, Hyo Sup, Chmielecki, Juliann, Pao, William, Engelman, Jeffrey A, Iafrate, A John, Le, Long Phi

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Epidermal Growth Factor Receptor Mutations in Non–Small-Cell Lung Cancer: Implications for Treatment and Tumor Biology von Pasi A. Jänne, Jeffrey A. Engelman, Bruce E. Johnson

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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial Cells von ISAKOFF, Steven J, ENGELMAN, Jeffrey A, IRIE, Hanna Y, JI LUO, BRACHMANN, Saskia M, PEARLINE, Rachel V, CANTLEY, Lewis C, BRUGGE, Joan S

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ErbB-3 Mediates Phosphoinositide 3-Kinase Activity in Gefitinib-Sensitive Non-Small Cell Lung Cancer Cell Lines von Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, Cichowski, Karen, Johnson, Bruce E., Cantley, Lewis C.

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Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins von SHIMAMURA, Takeshi, LOWELL, April M, ENGELMAN, Jeffrey A, SHAPIRO, Geoffrey I

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Differential Effects of Gefitinib and Cetuximab on Non–small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations von Mukohara, Toru, Engelman, Jeffrey A., Hanna, Nasser H., Yeap, Beow Y., Kobayashi, Susumu, Lindeman, Neal, Halmos, Balázs, Pearlberg, Joseph, Tsuchihashi, Zenta, Cantley, Lewis C., Tenen, Daniel G., Johnson, Bruce E., Jänne, Pasi A.

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Bronchial and Peripheral Murine Lung Carcinomas Induced by T790M-L858R Mutant EGFR Respond to HKI-272 and Rapamycin Combination Therapy von Li, Danan, Shimamura, Takeshi, Ji, Hongbin, Chen, Liang, Haringsma, Henry J., McNamara, Kate, Liang, Mei-Chih, Perera, Samanthi A., Zaghlul, Sara, Borgman, Christa L., Kubo, Shigeto, Takahashi, Masaya, Sun, Yanping, Chirieac, Lucian R., Padera, Robert F., Lindeman, Neal I., Jänne, Pasi A., Thomas, Roman K., Meyerson, Matthew L., Eck, Michael J., Engelman, Jeffrey A., Shapiro, Geoffrey I., Wong, Kwok-Kin

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Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities von Razani, Babak, Engelman, Jeffery A., Wang, Xiao Bo, Schubert, William, Zhang, Xiao Lan, Marks, Carolyn B., Macaluso, Frank, Russell, Robert G., Li, Maomi, Pestell, Richard G., Di Vizio, Dolores, Hou, Harry, Kneitz, Burkhard, Lagaud, Guy, Christ, George J., Edelmann, Winfried, Lisanti, Michael P.

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Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice von Brachmann, Saskia M., Ueki, Kohjiro, Engelman, Jeffrey A., Kahn, Ronald C., Cantley, Lewis C.

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A Sweet New Role for EGFR in Cancer von Engelman, Jeffrey A., Cantley, Lewis C.

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Caveolins, Liquid-Ordered Domains, and Signal Transduction von Smart, Eric J., Graf, Gregory A., McNiven, Mark A., Sessa, William C., Engelman, Jeffrey A., Scherer, Philipp E., Okamoto, Takashi, Lisanti, Michael P.

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Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities von Galbiati, Ferruccio, Engelman, Jeffrey A., Volonte, Daniela, Zhang, Xiao Lan, Minetti, Carlo, Li, Maomi, Hou, Harry, Kneitz, Burkhard, Edelmann, Winfried, Lisanti, Michael P.

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p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex von Luo, Ji, Field, Seth J, Lee, Jennifer Y, Engelman, Jeffrey A, Cantley, Lewis C

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Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae von Razani, Babak, Wang, Xiao Bo, Engelman, Jeffery A., Battista, Michela, Lagaud, Guy, Zhang, Xiao Lan, Kneitz, Burkhard, Hou, Harry, Christ, George J., Edelmann, Winfried, Lisanti, Michael P.

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Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade von Galbiati, Ferruccio, Volonté, Daniela, Engelman, Jeffrey A., Watanabe, Genichi, Burk, Robert, Pestell, Richard G., Lisanti, Michael P.

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Specific Inhibitors of p38 Mitogen-activated Protein Kinase Block 3T3-L1 Adipogenesis von Engelman, Jeffrey A., Lisanti, Michael P., Scherer, Philipp E.

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Molecular mechanisms of resistance to first- and second-generation ALK inhibitors in ALK-rearranged lung cancer von Gainor, J, Dardaei, L, Yoda, S, Friboulet, L, Leischler, I, Katayama, R, Dagogo-Jack, I, Gadgeel, S, Schultz, K, Singh, M, Chin, E, Parks, M, Lee, D, DiCecca, R.H, Lockerman, E, Huynh, T, Logan, J, Benes, C.H, Engelman, J.A, Shaw, A

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Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers von Engelman, Jeffrey A, Zhang, Xiao Lan, Lisanti, Michael P

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Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo von Scherer, P E, Lewis, R Y, Volonte, D, Engelman, J A, Galbiati, F, Couet, J, Kohtz, D S, van Donselaar, E, Peters, P, Lisanti, M P

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