Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models von Li, Fu, Emmerton, Kim K, Jonas, Mechthild, Zhang, Xinqun, Miyamoto, Jamie B, Setter, Jocelyn R, Nicholas, Nicole D, Okeley, Nicole M, Lyon, Robert P, Benjamin, Dennis R, Law, Che-Leung

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Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates von Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.

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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Setter, Jocelyn R, Hunter, Joshua H, Cochran, Julia H, Waight, Andrew B, Gordon, Kristine A, Toki, Brian E, Emmerton, Kim K, Zeng, Weiping, Stone, Ivan J, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C

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Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR + and Heterogeneous Tumor Models von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Lai, Holden W H, Leiske, Christopher I, Emmerton, Kim K, Waight, Andrew B, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C

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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates von Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.

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Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models von Moquist, Philip N, Bovee, Tim D, Waight, Andrew B, Mitchell, Jamie A, Miyamoto, Jamie B, Mason, Marsha L, Emmerton, Kim K, Stevens, Nicole, Balasubramanian, Cindy, Simmons, Jessica K, Lyon, Robert P, Senter, Peter D, Doronina, Svetlana O

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Development of Novel Antibody-Camptothecin Conjugates von Lyski, Ryan D, Bou, Lauren B, Lau, Uland Y, Meyer, David W, Cochran, Julia H, Okeley, Nicole M, Emmerton, Kim K, Zapata, Francisco, Simmons, Jessica K, Trueblood, Esther S, Ortiz, David J, Zaval, Margo C, Snead, Katie M, Jin, Steven, Farr, Lauren M, Ryan, Maureen C, Senter, Peter D, Jeffrey, Scott C

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Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins von Lau, Uland Y, Benoit, Lauren T, Stevens, Nicole S, Emmerton, Kim K, Zaval, Margo, Cochran, Julia H, Senter, Peter D

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Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation von Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.

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Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates von Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.

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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates von Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.

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Abstract A097: Tubulysin ADC payloads: An antimitotic drug class that retains activity in multidrug resistant models von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Emmerton, Kim K, Senter, Peter D, Jeffrey, Scott C

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Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities von Levengood, Matthew R., Zhang, Xinqun, Emmerton, Kim K., Hunter, Joshua H., Senter, Peter D.

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Front Cover: Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation (ChemMedChem 7/2021) von Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.

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Abstract 2803: Novel auristatins with high activity on efflux-positive models and demonstrable bystander activity von Moquist, Philip N., Bovee, Tim D., Waight, Andrew B., Owen, Sarah, Mitchell, Jamie A., Zaval, Margo, Quick, Marsha, Sandall, Sharsti, Emmerton, Kim K., Blesie, Nicole, Lyon, Robert P., Senter, Peter, Doronina, Svetlana

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Abstract 1649: Impact of linker and conjugation site on tubulysin M ADC stability and in vivo activity von Burke, Patrick J., Hamilton, Joseph Z., Pires, Thomas A., Leiske, Christopher I., Cochran, Julia H., Setter, Jocelyn R., Emmerton, Kim K., Waight, Andrew B., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.

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Abstract 56: Antibody-drug conjugates containing glucuronide-tubulysin payloads display activity in MDR+ and heterogeneous tumor models von Burke, Patrick J., Hamilton, Joseph Z., Hunter, Joshua H., Cochran, Julia H., Pires, Thomas A., Leiske, Christopher I., Emmerton, Kim K., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.

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Canadian Surgery Forum von Fayez, R, Roy, M, Villeneuve, S, AlMuntashery, A, Demyttenaere, S, Christou, N, Court, O, Bodie, G, Bonrath, E, Hagen, J, Okrainec, A, Sullivan, P, Grantcharov, T, Almamar, A, Sharma, A, Karmali, S, Birch, D W, Gill, R S, Majumdar, S R, Wang, X, Tuepah, R, Klarenbach, S W, Birch, D W, Karmali, S, Sharma, A M, Padwal, R J, Raîche, I, Smith, C, Haggar, F, Moloo, H, Poulin, E C, Martel, G, Yelle, J-D, Mamazza, J, Mueller, C L, Jackson, T D, Penner, T, Pitzul, K, Urbach, D R, Moustarah, F, Biertho, L, Hould, F-S, Lebel, S, Lescelleur, O, Marceau, S, Marceau, P, Biron, S, Khokhotva, M, Grantcharov, T, Anvari, M, Sharma, A, Yusuf, S, Kwong, J, Okrainec, A, Pitzul, K B, Urbach, D R, Jackson, T, Elkassem, S, Lindsay, D, Sullivan, P, Smith, L, Bonrath, E, Zevin, B, Dedy, N, Grantcharov, T P, Zevin, B, Bonrath, E M, Aggarwal, R, Grantcharov, T, Sockalingam, S, Cassin, S, Crawford, S, Pitzul, K, Khan, A, Hawa, R

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