Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study von Davenport, Emma E, DPhil, Burnham, Katie L, MGen, Radhakrishnan, Jayachandran, DPhil, Humburg, Peter, PhD, Hutton, Paula, PG Cert, Mills, Tara C, DPhil, Rautanen, Anna, PhD, Gordon, Anthony C, MD, Garrard, Christopher, DPhil, Hill, Adrian V S, Prof, Hinds, Charles J, Prof, Knight, Julian C, Prof

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Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis von Kwok, Andrew J., Allcock, Alice, Ferreira, Ricardo C., Cano-Gamez, Eddie, Smee, Madeleine, Burnham, Katie L., Zurke, Yasemin-Xiomara, McKechnie, Stuart, Mentzer, Alexander J., Monaco, Claudia, Udalova, Irina A., Hinds, Charles J., Todd, John A., Davenport, Emma E., Knight, Julian C.

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Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 von Maher, Allison K., Burnham, Katie L., Jones, Emma M., Tan, Michelle M. H., Saputil, Rocel C., Baillon, Laury, Selck, Claudia, Giang, Nicolas, Argüello, Rafael, Pillay, Clio, Thorley, Emma, Short, Charlotte-Eve, Quinlan, Rachael, Barclay, Wendy S., Cooper, Nichola, Taylor, Graham P., Davenport, Emma E., Dominguez-Villar, Margarita

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A community approach to mortality prediction in sepsis via gene expression analysis von Sweeney, Timothy E., Perumal, Thanneer M., Henao, Ricardo, Nichols, Marshall, Howrylak, Judith A., Choi, Augustine M., Bermejo-Martin, Jesús F., Almansa, Raquel, Tamayo, Eduardo, Davenport, Emma E., Burnham, Katie L., Hinds, Charles J., Knight, Julian C., Woods, Christopher W., Kingsmore, Stephen F., Ginsburg, Geoffrey S., Wong, Hector R., Parnell, Grant P., Tang, Benjamin, Moldawer, Lyle L., Moore, Frederick E., Omberg, Larsson, Khatri, Purvesh, Tsalik, Ephraim L., Mangravite, Lara M., Langley, Raymond J.

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Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia von Burnham, Katie L, Davenport, Emma E, Radhakrishnan, Jayachandran, Humburg, Peter, Gordon, Anthony C, Hutton, Paula, Svoren-Jabalera, Eduardo, Garrard, Christopher, Hill, Adrian V S, Hinds, Charles J, Knight, Julian C

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IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors von Amariuta, Tiffany, Luo, Yang, Gazal, Steven, Davenport, Emma E., van de Geijn, Bryce, Ishigaki, Kazuyoshi, Westra, Harm-Jan, Teslovich, Nikola, Okada, Yukinori, Yamamoto, Kazuhiko, Price, Alkes L., Raychaudhuri, Soumya

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Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study von Scicluna, Brendon P, van Vught, Lonneke A, Zwinderman, Aeilko H, Wiewel, Maryse A, Davenport, Emma E, Burnham, Katie L, Nürnberg, Peter, Schultz, Marcus J, Horn, Janneke, Cremer, Olaf L, Bonten, Marc J, Hinds, Charles J, Wong, Hector R, Knight, Julian C, van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D.J., Frencken, Jos F., Koster-Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Hoogendijk, Arie J., Huson, Mischa A., Klouwenberg, Peter M. Klein, Ong, David S.Y., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk

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Genetically personalised organ-specific metabolic models in health and disease von Foguet, Carles, Xu, Yu, Ritchie, Scott C., Lambert, Samuel A., Persyn, Elodie, Nath, Artika P., Davenport, Emma E., Roberts, David J., Paul, Dirk S., Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S., Yau, Christopher, Inouye, Michael

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Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes von Macrae, Robyn G C, Colzani, Maria T, Williams, Thomas L, Bayraktar, Semih, Kuc, Rhoda E, Pullinger, Anna L, Bernard, William G, Robinson, Emma L, Davenport, Emma E, Maguire, Janet J, Sinha, Sanjay, Davenport, Anthony P

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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response von Ali, Maruf M U, Bagratuni, Tina, Davenport, Emma L, Nowak, Piotr R, Silva-Santisteban, M Cris, Hardcastle, Anthea, McAndrews, Craig, Rowlands, Martin G, Morgan, Gareth J, Aherne, Wynne, Collins, Ian, Davies, Faith E, Pearl, Laurence H

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An atlas of genetic scores to predict multi-omic traits von Xu, Yu, Ritchie, Scott C., Liang, Yujian, Timmers, Paul R. H. J., Pietzner, Maik, Lannelongue, Loïc, Lambert, Samuel A., Tahir, Usman A., May-Wilson, Sebastian, Foguet, Carles, Johansson, Åsa, Surendran, Praveen, Nath, Artika P., Persyn, Elodie, Peters, James E., Oliver-Williams, Clare, Deng, Shuliang, Prins, Bram, Luan, Jian’an, Bomba, Lorenzo, Soranzo, Nicole, Di Angelantonio, Emanuele, Pirastu, Nicola, Tai, E. Shyong, van Dam, Rob M., Parkinson, Helen, Davenport, Emma E., Paul, Dirk S., Yau, Christopher, Gerszten, Robert E., Mälarstig, Anders, Danesh, John, Sim, Xueling, Langenberg, Claudia, Wilson, James F., Butterworth, Adam S., Inouye, Michael

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Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein von Owen, Nicola E, Williams, Thomas L, Maguire, Janet J, Kuc, Rhoda E, Davenport, Emma E, Davenport, Anthony P

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Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study von Rautanen, Anna, Dr, Mills, Tara C, DPhil, Gordon, Anthony C, MD, Hutton, Paula, PG Cert, Steffens, Michael, MD, Nuamah, Rosamond, BSc, Chiche, Jean-Daniel, Prof, Parks, Tom, MB, Chapman, Stephen J, DM, Davenport, Emma E, MBiochem, Elliott, Katherine S, PhD, Bion, Julian, Prof, Lichtner, Peter, PhD, Meitinger, Thomas, Prof, Wienker, Thomas F, Prof, Caulfield, Mark J, Prof, Mein, Charles, PhD, Bloos, Frank, MD, Bobek, Ilona, PhD, Cotogni, Paolo, MD, Sramek, Vladimir, MD, Sarapuu, Silver, MD, Kobilay, Makbule, Ranieri, V Marco, Prof, Rello, Jordi, Prof, Sirgo, Gonzalo, MD, Weiss, Yoram G, MD, Russwurm, Stefan, MD, Schneider, E Marion, PhD, Reinhart, Konrad, Prof, Holloway, Paul A H, PhD, Knight, Julian C, Prof, Garrard, Chris S, MD, Russell, James A, Prof, Walley, Keith R, Prof, Stüber, Frank, Prof, Hill, Adrian V S, Prof, Hinds, Charles J, Prof

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Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial von Davenport, Emma E, Amariuta, Tiffany, Gutierrez-Arcelus, Maria, Slowikowski, Kamil, Westra, Harm-Jan, Luo, Yang, Shen, Ciyue, Rao, Deepak A, Zhang, Ying, Pearson, Stephen, von Schack, David, Beebe, Jean S, Bing, Nan, John, Sally, Vincent, Michael S, Zhang, Baohong, Raychaudhuri, Soumya

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Interactions Between Genome‐Wide Genetic Factors and Smoking Influencing Risk of Systemic Lupus Erythematosus von Cui, Jing, Raychaudhuri, Soumya, Karlson, Elizabeth W., Speyer, Cameron, Malspeis, Susan, Guan, Hongshu, Sparks, Jeffrey A., Ni, Hongru, Liu, Xinyi, Stevens, Emma, Williams, Jessica N., Davenport, Emma E., Knevel, Rachel, Costenbader, Karen H.

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Transcriptomic profiling facilitates classification of response to influenza challenge von Davenport, Emma E., Antrobus, Richard D., Lillie, Patrick J., Gilbert, Sarah, Knight, Julian C.

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Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders von van Schouwenburg, Pauline A, Davenport, Emma E, Kienzler, Anne-Kathrin, Marwah, Ishita, Wright, Benjamin, Lucas, Mary, Malinauskas, Tomas, Martin, Hilary C, Lockstone, Helen E, Cazier, Jean-Baptiste, Chapel, Helen M, Knight, Julian C, Patel, Smita Y

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Misexpression of inactive genes in whole blood is associated with nearby rare structural variants von Vanderstichele, Thomas, Burnham, Katie L., de Klein, Niek, Tardaguila, Manuel, Howell, Brittany, Walter, Klaudia, Kundu, Kousik, Koeppel, Jonas, Lee, Wanseon, Tokolyi, Alex, Persyn, Elodie, Nath, Artika P., Marten, Jonathan, Petrovski, Slavé, Roberts, David J., Di Angelantonio, Emanuele, Danesh, John, Berton, Alix, Platt, Adam, Butterworth, Adam S., Soranzo, Nicole, Parts, Leopold, Inouye, Michael, Paul, Dirk S., Davenport, Emma E.

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XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments von Bagratuni, Tina, Wu, Ping, Gonzalez de Castro, David, Davenport, Emma L., Dickens, Nicholas J., Walker, Brian A., Boyd, Kevin, Johnson, David C., Gregory, Walter, Morgan, Gareth J., Davies, Faith E.

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Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells von Davenport, Emma L., Moore, Hannah E., Dunlop, Alan S., Sharp, Swee Y., Workman, Paul, Morgan, Gareth J., Davies, Faith E.

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