PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy von Jani, Jitesh P, Arcari, Joel, Bernardo, Vincent, Bhattacharya, Samit K, Briere, David, Cohen, Bruce D, Coleman, Kevin, Christensen, James G, Emerson, Erling O, Jakowski, Amy, Hook, Kenneth, Los, Gerrit, Moyer, James D, Pruimboom-Brees, Ingrid, Pustilnik, Leslie, Rossi, Ann Marie, Steyn, Stefan J, Su, Chunyan, Tsaparikos, Konstantinos, Wishka, Donn, Yoon, Kwansik, Jakubczak, John L

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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor von JANI, Jitesh P, FINN, Richard S, MORRIS, Joel, MOYER, James D, PUSTILNIK, Leslie R, RAFIDI, Kristina, RALSTON, Sherry, ROSSI, Ann Marie K, STEYN, Stefanus J, WAGNER, Larry, WINTER, Steven M, BHATTACHARYA, Samit K, CAMPBELL, Mary, COLEMAN, Kevin G, CONNELL, Richard D, CURRIER, Nicolas, EMERSON, Erling O, FLOYD, Eugenia, HARRIMAN, Shawn, KATH, John C

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Abstract 5466: The Mdm2 inhibitor, NVP-CGM097, in combination with the BRAF inhibitor NVP-LGX818 elicits synergistic antitumor effects in melanoma von Wang, Hui Qin, Zubrowski, Matthew, Emerson, Erling, Pradhan, Elina, Jeay, Sébastien, Wiesmann, Marion, Caponigro, Giordano, Wuerthner, Jens, Schlegel, Robert, Cao, Z. Alexander, Huang, Alan, Halilovic, Ensar

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Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy von Beebe, Jean S, Jani, Jitesh P, Knauth, Elisabeth, Goodwin, Peter, Higdon, Carla, Rossi, Ann Marie, Emerson, Erling, Finkelstein, Martin, Floyd, Eugenia, Harriman, Shawn, Atherton, Jim, Hillerman, Steve, Soderstrom, Cathy, Kou, Kou, Gant, Tom, Noe, Mark C, Foster, Barb, Rastinejad, Farzan, Marx, Matthew A, Schaeffer, Tracey, Whalen, Pamela M, Roberts, W Gregory

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Abstract A86: Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors von Roberts, Walter Gregory, Berliner, Martin, Coleman, Kevin, Emerson, Erling, Griffor, Matt, Hulford, Catherine, Jani, Jitesh, Kath, John, LaGreca, Susan, Lin, Jing, Lorenzen, Marianne J., Marr, Eric, Martinez-Alsina, Luis, Patel, Nandini, Richter, Daniel, Roberts, Erika, Autry, Christopher, Ung, Ethan, Felix, Vajdos, Vetelino, Beth, Wessel, Matthew, Whalen, Pamela, Xu, Huiping, Yao, Lili

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The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells von BARBACCI, E. Gabriella, PUSTILNIK, Leslie R, KATH, John C, ZHENGYU LIU, MOYER, James D, ROSSI, Ann Marie K, EMERSON, Erling, MILLER, Penny E, BOSCOE, Brian P, COX, Eric D, IWATA, Kenneth K, JANI, Jitesh P, PROVONCHA, Kathleen

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Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587) von DIONNE, C. A, CAMORATTO, A. M, GEORGE, D, ISAACS, J. T, JANI, J. P, EMERSON, E, NEFF, N, VAUGHT, J. L, MURAKATA, C, DJAKIEW, D, LAMB, J, BOVA, S

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Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy1 von BEEBE, Jean S, JANI, Jitesh P, ATHERTON, Jim, HILLERMAN, Steve, SODERSTROM, Cathy, KOU KOU, GANT, Tom, NOE, Mark C, FOSTER, Barb, RASTINEJAD, Farzan, MARX, Matthew A, SCHAEFFER, Tracey, KNAUTH, Elisabeth, WHALEN, Pamela M, ROBERTS, W. Gregory, GOODWIN, Peter, HIGDON, Carla, ROSSI, Ann Marie, EMERSON, Erling, FINKELSTEIN, Martin, FLOYD, Eugenia, HARRIMAN, Shawn

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COMBINATION OF MDM2 INHIBITOR AND BRAF INHIBITOR AND THEIR USE von ZUBROWSKI, MATTHEW, HALILOVIC, ENSAR, EMERSON, ERLING, WANG, HUI-QIN

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Biochemical characterization of a mitomycin C‐resistant human bladder cancer cell line von Singh, Shivendra V., Scalamogna, Domenic, Xia, Hong, O'Toole, Stacy, Roy, Deodutta, Emerson, Erling O., Gupta, Vicram, Zaren, Howard A.

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Mechanism of cross‐resistance to cisplatin in a mitomycin C‐resistant human bladder cancer cell line von Singh, Shivendra V., Xu, Bing H., Jani, Jitesh P., Emerson, Erling O., Backes, Mary G., Rihn, Christopher, Scalamogna, Domenic, Stemmler, Nancy, Specht, Susan, Blanock, Kurt, Katoh, Arthur, Gupta, Vicram

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Characterization of a human bladder cancer cell line selected for resistance to BMY 25067, a novel analogue of mitomycin C von Singh, Shivendra V., Xu, Bing H., Gupta, Vicram, Emerson, Erling O., Zaren, Howard A., Jani, Jitesh P.

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Modulation of cisplatin sensitivity and accumulation by interferon α‐2A in human squamous carcinoma cell lines von Gupta, Vicram, Jani, Jitesh P., Emerson, Erling O., Xu, Bing H., Scalamogna, Domenic, Xia, Hong, Katoh, Arthur, Zaren, Howard A., Singh, Shivendra V.

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Combination of Mdm2 inhibitor and BRAF inhibitor and their use von ZUBROWSKI, MATTHEW, HALILOVIC, ENSAR, EMERSON, ERLING, WANG, HUI-QIN

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