Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model von Young, Wendy B., Mordenti, Joyce, Torkelson, Steven, Shrader, William D., Kolesnikov, Aleksandr, Rai, Roopa, Liu, Liang, Hu, Huiyong, Leahy, Ellen M., Green, Michael J., Sprengeler, Paul A., Katz, Bradley A., Yu, Christine, Janc, James W., Elrod, Kyle C., Marzec, Ulla M., Hanson, Stephen R.

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Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep von ELROD, K. C, MOORE, W. R, ABRAHAM, W. M, TANAKA, R. D

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High-Throughput Screening of Enzyme Inhibitors: Simultaneous Determination of Tight-Binding Inhibition Constants and Enzyme Concentration von Kuzmič, Petr, Elrod, Kyle C, Cregar, Lynne M, Sideris, Steve, Rai, Roopa, Janc, James W

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Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor von Selwood, Trevor, Elrod, Kyle C, Schechter, Norman M

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Small molecule inhibitors of plasma kallikrein von Young, Wendy B., Rai, Roopa, Shrader, William D., Burgess-Henry, Jana, Hu, Huiyong, Elrod, Kyle C., Sprengeler, Paul A., Katz, Bradley A., Sukbuntherng, Juthamas, Mordenti, Joyce

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RBC-Specific CD47 Pruning Confers Protection and Underlies the Transient Anemia in Patients Treated with Anti-CD47 Antibody 5F9 von Chen, James Y, McKenna, Kelly Marie, Choi, Timothy S, Duan, Jiaqi, Brown, Lynette, Stewart, Jennifer J, Sompalli, Kavitha, Vyas, Paresh, Schrier, Stanley, Majeti, Ravindra, Weissman, Irving L, Elrod, Kyle, Chao, Mark Ping, Takimoto, Chris H, Liu, Jie, Volkmer, Jens-Peter

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A Novel Approach to Serine Protease Inhibition:  Kinetic Characterization of Inhibitors Whose Potencies and Selectivities Are Dramatically Enhanced by Zinc(II) von Janc, James W, Clark, James M, Warne, Robert L, Elrod, Kyle C, Katz, Bradley A, Moore, William R

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High-Throughput Screening of Enzyme Inhibitors: Automatic Determination of Tight-Binding Inhibition Constants von Kuzmič, Petr, Sideris, Steve, Cregar, Lynne M., Elrod, Kyle C., Rice, Kenneth D., Janc, James W.

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Emerging therapeutic targets in asthma: the rationale for mast cell tryptase inhibition von Elrod, Kyle C, Numerof, Robert P

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Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease von Dhanak, Dashyant, Burton, George, Christmann, Lisa T, Darcy, Michael G, Elrod, Kyle C, Kaura, Arun, Keenan, Richard M, Link, John O, Peishoff, Catherine E, Shah, Dinubhai H

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Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor von Ho, Joseph D., Meltser, Yana, Buggy, Joseph J., Palmer, James T., Elrod, Kyle C., Chan, Hedy, Mortara, Kyle D., Somoza, John R.

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A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site von Katz, Bradley A, Elrod, Kyle, Luong, Christine, Rice, Mark J, Mackman, Richard L, Sprengeler, Paul A, Spencer, Jeffrey, Hataye, Jason, Janc, James, Link, John, Litvak, Joane, Rai, Roopa, Rice, Ken, Sideris, Steve, Verner, Erik, Young, Wendy

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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors von Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.

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Optimization of a screening lead for factor VIIa/TF von Young, Wendy B, Kolesnikov, Aleksandr, Rai, Roopa, Sprengeler, Paul A, Leahy, Ellen M, Shrader, William D, Sangalang, Joan, Burgess-Henry, Jana, Spencer, Jeff, Elrod, Kyle, Cregar, Lynne

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Neutrophil Myeloperoxidase Is a Potent and Selective Inhibitor of Mast Cell Tryptase von Cregar, Lynne, Elrod, Kyle C., Putnam, Daun, Moore, William R.

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Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation von Young, Wendy B., Sprengeler, Paul, Shrader, William D., Li, Yong, Rai, Roopa, Verner, Erik, Jenkins, Thomas, Fatheree, Paul, Kolesnikov, Aleksandr, Janc, James W., Cregar, Lynne, Elrod, Kyle, Katz, Brad

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Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors von Katz, Bradley A, Spencer, Jeffrey R, Elrod, Kyle, Luong, Christine, Mackman, Richard L, Rice, Mark, Sprengeler, Paul A, Allen, Darin, Janc, James

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Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease von Sperandio, David, Gangloff, Anthony R., Litvak, Joane, Goldsmith, Richard, Hataye, Jason M., Wang, Vivian R., Shelton, Emma J., Elrod, Kyle, Janc, James W., Clark, James M., Rice, Ken, Weinheimer, Steve, Yeung, Kap-Sun, Meanwell, Nicholas A., Hernandez, Dennis, Staab, Andrew J., Venables, Brian L., Spencer, Jeffrey R.

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Neutral inhibitors of the serine protease factor Xa von SHRADER, William D, YOUNG, Wendy B, SPRENGELER, Paul A, SANGALANG, Joan C, ELROD, Kyle, CARR, Grant

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Development of potent and selective factor Xa inhibitors von RAI, Roopa, KOLESNIKOV, Aleksandr, ALLEN, Darin, CHEN, Xi, KATZ, Bradley A, LUONG, Christine, ELROD, Kyle, CREGAR, Lynne, YONG LI, YOUNG, Wendy B, LEAHY, Ellen, SPRENGELER, Paul A, VERNER, Erik, SHRADER, William D, BURGESS-HENRY, Jana, SANGALANG, Joan C

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