Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour act... von Wilson, Wyndham H, Prof, O'Connor, Owen A, Prof, Czuczman, Myron S, Prof, LaCasce, Ann S, MD, Gerecitano, John F, MD, Leonard, John P, Prof, Tulpule, Anil, MD, Dunleavy, Kieron, MD, Xiong, Hao, PhD, Chiu, Yi-Lin, PhD, Cui, Yue, PhD, Busman, Todd, MS, Elmore, Steven W, PhD, Rosenberg, Saul H, PhD, Krivoshik, Andrew P, MD, Enschede, Sari H, MD, Humerickhouse, Rod A, MD

Volltext

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines von Zhang, H, Guttikonda, S, Roberts, L, Uziel, T, Semizarov, D, Elmore, S W, Leverson, J D, Lam, L T

Volltext

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor von Tse, Christin, Shoemaker, Alexander R, Adickes, Jessica, Anderson, Mark G, Chen, Jun, Jin, Sha, Johnson, Eric F, Marsh, Kennan C, Mitten, Michael J, Nimmer, Paul, Roberts, Lisa, Tahir, Stephen K, Xiao, Yu, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen, Rosenberg, Saul H, Elmore, Steven W

Volltext

Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition von Griggs, Lauren A., Hassan, Nadiah T., Malik, Roshni S., Griffin, Brian P., Martinez, Brittany A., Elmore, Lynne W., Lemmon, Christopher A.

Volltext

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor von Xiao, Yu, Nimmer, Paul, Sheppard, George S, Bruncko, Milan, Hessler, Paul, Lu, Xin, Roberts-Rapp, Lisa, Pappano, William N, Elmore, Steven W, Souers, Andrew J, Leverson, Joel D, Phillips, Darren C

Volltext

Extensins: Self-Assembly, Crosslinking, and the Role of Peroxidases von Mishler-Elmore, John W., Zhou, Yadi, Sukul, Abhijit, Oblak, Mercedes, Tan, Li, Faik, Ahmed, Held, Michael A.

Volltext

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins von Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

Volltext

Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites von Sachs, Patrick C, Francis, Michael P, Zhao, Min, Brumelle, Jenni, Rao, Raj R, Elmore, Lynne W, Holt, Shawn E

Volltext

Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study von Alhareeri, Areej A., Archer, Kellie J., Fu, Han, Lyon, Debra E., Elswick, R. K., Kelly, Debra L., Starkweather, Angela R., Elmore, Lynne W., Bokhari, Yahya A., Jackson-Cook, Colleen K.

Volltext

Soybean Sowing Date: The Vegetative, Reproductive, and Agronomic Impacts von Bastidas, A.M, Setiyono, T.D, Dobermann, A, Cassman, K.G, Elmore, R.W, Graef, G.L, Specht, J.E

Volltext

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737 von TAHIR, Stephen K, XIUFEN YANG, ROSENBERG, Saul H, TSE, Christin, ANDERSON, Mark G, MORGAN-LAPPE, Susan E, SARTHY, Aparna V, JUN CHEN, WARNER, Robert B, NG, Shi-Chung, FESIK, Stephen W, ELMORE, Steve W

Volltext

Class III Peroxidases PRX01, PRX44, and PRX73 Control Root Hair Growth in Arabidopsis thaliana von Marzol, Eliana, Borassi, Cecilia, Carignani Sardoy, Mariana, Ranocha, Philippe, Aptekmann, Ariel A, Bringas, Mauro, Pennington, Janice, Paez-Valencia, Julio, Martínez Pacheco, Javier, Rodríguez-Garcia, Diana R, Rondón Guerrero, Yossmayer Del Carmen, Peralta, Juan Manuel, Fleming, Margaret, Mishler-Elmore, John W, Mangano, Silvina, Blanco-Herrera, Francisca, Bedinger, Patricia A, Dunand, Christophe, Capece, Luciana, Nadra, Alejandro D, Held, Michael, Otegui, Marisa S, Estevez, José M

Volltext

Bcl-2 family proteins are essential for platelet survival von Zhang, H, Nimmer, P M, Tahir, S K, Chen, J, Fryer, R M, Hahn, K R, Iciek, L A, Morgan, S J, Nasarre, M C, Nelson, R, Preusser, L C, Reinhart, G A, Smith, M L, Rosenberg, S H, Elmore, S W, Tse, C

Volltext

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models von SHOEMAKER, Alex R, MITTEN, Michael J, BAUCH, Joy, MARSH, Kennan, TAHIR, Steven K, XIUFENYANG, TSE, Christin, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, ADICKES, Jessica, ACKLER, Scott, REFICI, Marion, FERGUSON, Debra, OLEKSIJEW, Anatol, O'CONNOR, Jacqueline M, BAOLE WANG, FROST, David J

Volltext

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets von Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W

Volltext

Adriamycin-induced Senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction von Elmore, Lynne W, Rehder, Catherine W, Di, Xu, McChesney, Patricia A, Jackson-Cook, Colleen K, Gewirtz, David A, Holt, Shawn E

Volltext

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin von Sankala, Heidi M, Hait, Nitai C, Paugh, Steven W, Shida, Dai, Lépine, Sandrine, Elmore, Lynne W, Dent, Paul, Milstien, Sheldon, Spiegel, Sarah

Volltext

Posttranscriptional regulation of cellulose synthase genes by small RNAs derived from cellulose synthase antisense transcripts von Nething, Daniel B., Sukul, Abhijit, Mishler‐Elmore, John W., Held, Michael A.

Volltext

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo von Ackler, Scott, Mitten, Michael J., Foster, Kelly, Oleksijew, Anatol, Refici, Marion, Tahir, Stephen K., Xiao, Yu, Tse, Christin, Frost, David J., Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W., Shoemaker, Alexander R.

Volltext

Evasion of a Single-Step, Chemotherapy-Induced Senescence in Breast Cancer Cells: Implications for Treatment Response von ELMORE, Lynne W, XU DI, DUMUR, Catherine, HOLT, Shawn E, GEWIRTZ, David A

Volltext