Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo von Dowdle, William E., Nyfeler, Beat, Nagel, Jane, Elling, Robert A., Liu, Shanming, Triantafellow, Ellen, Menon, Suchithra, Wang, Zuncai, Honda, Ayako, Pardee, Gwynn, Cantwell, John, Luu, Catherine, Cornella-Taracido, Ivan, Harrington, Edmund, Fekkes, Peter, Lei, Hong, Fang, Qing, Digan, Mary Ellen, Burdick, Debra, Powers, Andrew F., Helliwell, Stephen B., D’Aquin, Simon, Bastien, Julie, Wang, Henry, Wiederschain, Dmitri, Kuerth, Jenny, Bergman, Philip, Schwalb, David, Thomas, Jason, Ugwonali, Savuth, Harbinski, Fred, Tallarico, John, Wilson, Christopher J., Myer, Vic E., Porter, Jeffery A., Bussiere, Dirksen E., Finan, Peter M., Labow, Mark A., Mao, Xiaohong, Hamann, Lawrence G., Manning, Brendan D., Valdez, Reginald A., Nicholson, Thomas, Schirle, Markus, Knapp, Mark S., Keaney, Erin P., Murphy, Leon O.

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Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism von Dovala, Dustin, Rath, Christopher M., Hu, Qijun, Sawyer, William S., Shia, Steven, Elling, Robert A., Knapp, Mark S., Metzger, Louis E.

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Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies von Di Luccio, Eric, Elling, Robert A, Wilson, David K

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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery von Erlanson, Daniel A., Arndt, Joseph W., Cancilla, Mark T., Cao, Kathy, Elling, Robert A., English, Nicki, Friedman, Jessica, Hansen, Stig K., Hession, Cathy, Joseph, Ingrid, Kumaravel, Gnanasambandam, Lee, Wen-Cherng, Lind, Ken E., McDowell, Robert S., Miatkowski, Konrad, Nguyen, Christine, Nguyen, Thinh B., Park, Sophia, Pathan, Nuzhat, Penny, David M., Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Simmons, Robert L., Tangonan, Bradley T., Yang, Wenjin, Sun, Lihong

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Discovery of a potent and selective Aurora kinase inhibitor von Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

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Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors von Barsanti, Paul A, Aversa, Robert J, Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

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Structure-Guided Engineering of Xylitol Dehydrogenase Cosubstrate Specificity von Ehrensberger, Andreas H., Elling, Robert A., Wilson, David K.

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Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands von Elling, Robert A., Fucini, Raymond V., Romanowski, Michael J.

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Structure of Toxoplasma gondii LDH1:  Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use von Kavanagh, Kathryn L, Elling, Robert A, Wilson, David K

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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors von Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin

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2-Aminobenzimidazoles as potent Aurora kinase inhibitors von Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors von Fucini, Raymond V., Hanan, Emily J., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Barr, Kenneth J., Zhu, Jiang, Yoburn, Joshua C., Liu, Yang, Fahr, Bruce T., Fan, Junfa, Lu, Yafan, Pham, Phuongly, Choong, Ingrid C., VanderPorten, Erica C., Bui, Minna, Purkey, Hans E., Evanchik, Marc J., Yang, Wenjin

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Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors von Lu, Yipin, Knapp, Mark, Crawford, Kenneth, Warne, Robert, Elling, Robert, Yan, Kelly, Doyle, Michael, Pardee, Gwynn, Zhang, Li, Ma, Sylvia, Mamo, Mulugeta, Ornelas, Elizabeth, Pan, Yue, Bussiere, Dirksen, Jansen, Johanna, Zaror, Isabel, Lai, Albert, Barsanti, Paul, Sim, Janet

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Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes von Bonazzi, Simone, Gray, Audrey, Thomsen, Noel M., Biag, Jonathan, Labbe-Giguere, Nancy, Keaney, Erin P., Malik, Hasnain A., Sun, Yingchuan, Nunez, Jill, Karki, Rajeshri G., Knapp, Mark, Elling, Robert, Fuller, John, Pardee, Gwynn, Craig, Lucas, Capre, Ketthsy, Salas, Sarah, Gorde, Aakruti, Liang, Guiqing, Lubicka, Danuta, McTighe, Stephanie M., Goold, Carleton, Liu, Shanming, Deng, Lin, Hong, Jin, Fekete, Alexander, Stadelmann, Pascal, Frieauff, Wilfried, Elhajouji, Azeddine, Bauer, Daniel, Lerchner, Andreas, Radetich, Branko, Furet, Pascal, Piizzi, Grazia, Burdette, Doug, Wilson, Christopher J., Peukert, Stefan, Hamann, Lawrence G., Murphy, Leon O., Curtis, Daniel

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Mouse Aurora A: Expression in Escherichia coli and purification von Elling, Robert A., Tangonan, Bradley T., Penny, David M., Smith, Jeremy T., Vincent, Diana E., Hansen, Stig K., O’Brien, Tom, Romanowski, Michael J.

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Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy von Dixon, Seth, Robins, Lori, Elling, Robert A., Liu, Ruiwu, Lam, Kit S., Wilson, David K., Kurth, Mark J.

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Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition von Fu, Jiping, Tjandra, Meiliana, Becker, Christopher, Bednarczyk, Dallas, Capparelli, Michael, Elling, Robert, Hanna, Imad, Fujimoto, Roger, Furegati, Markus, Karur, Subramanian, Kasprzyk, Theresa, Knapp, Mark, Leung, Kwan, Li, Xiaolin, Lu, Peichao, Mergo, Wosenu, Miault, Charlotte, Ng, Simon, Parker, David, Peng, Yunshan, Roggo, Silvio, Rivkin, Alexey, Simmons, Robert L, Wang, Michael, Wiedmann, Brigitte, Weiss, Andrew H, Xiao, Linda, Xie, Lili, Xu, Wenjian, Yifru, Aregahegn, Yang, Shengtian, Zhou, Bo, Sweeney, Zachary K

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Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model von Han, Wooseok, Menezes, Daniel L., Xu, Yongjin, Knapp, Mark S., Elling, Robert, Burger, Matthew T., Ni, Zhi-Jie, Smith, Aaron, Lan, Jiong, Williams, Teresa E., Verhagen, Joelle, Huh, Kay, Merritt, Hanne, Chan, John, Kaufman, Susan, Voliva, Charles F., Pecchi, Sabina

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Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme von Elling, Robert A., Fucini, Raymond V., Hanan, Emily J., Barr, Kenneth J., Zhu, Jiang, Paulvannan, Kumar, Yang, Wenjin, Romanowski, Michael J.

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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors von Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

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