Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets von Van Aller, Glenn S., Graves, Alan P., Elkins, Patricia A., Bonnette, William G., McDevitt, Patrick J., Zappacosta, Francesca, Annan, Roland S., Dean, Tony W., Su, Dai-Shi, Carpenter, Christopher L., Mohammad, Helai P., Kruger, Ryan G.

Volltext

Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases von Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

Volltext

CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma von Carlson, Heather A, Smith, Richard D, Damm-Ganamet, Kelly L, Stuckey, Jeanne A, Ahmed, Aqeel, Convery, Maire A, Somers, Donald O, Kranz, Michael, Elkins, Patricia A, Cui, Guanglei, Peishoff, Catherine E, Lambert, Millard H, Dunbar, James B

Volltext

Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase von Elkins, Patricia A., Ho, Yen Sen, Smith, Ward W., Janson, Cheryl A., D'Alessio, Karla J., McQueney, Michael S., Cummings, Maxwell D., Romanic, Anne M.

Volltext

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin von Knight, Steven D, Adams, Nicholas D, Burgess, Joelle L, Chaudhari, Amita M, Darcy, Michael G, Donatelli, Carla A, Luengo, Juan I, Newlander, Ken A, Parrish, Cynthia A, Ridgers, Lance H, Sarpong, Martha A, Schmidt, Stanley J, Van Aller, Glenn S, Carson, Jeffrey D, Diamond, Melody A, Elkins, Patricia A, Gardiner, Christine M, Garver, Eric, Gilbert, Seth A, Gontarek, Richard R, Jackson, Jeffrey R, Kershner, Kevin L, Luo, Lusong, Raha, Kaushik, Sherk, Christian S, Sung, Chiu-Mei, Sutton, David, Tummino, Peter J, Wegrzyn, Ronald J, Auger, Kurt R, Dhanak, Dashyant

Volltext

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure von Cadilla, Rodolfo, Deaton, David N., Do, Young, Elkins, Patricia A., Ennulat, Daniela, Guss, Jeffrey H., Holt, Jason, Jeune, Michael R., King, Andrew G., Klapwijk, Jan C., Kramer, H. Fritz, Kramer, Nicholas J., Laffan, Susan B., Masuria, Paresh I., McDougal, Alan V., Mortenson, Paul N., Musetti, Caterina, Peckham, Gregory E., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Rendina, Alan R., Sati, Girish, Saxty, Gordon, Shearer, Barry G., Shewchuk, Lisa M., Sneddon, Helen F., Stewart, Eugene L., Stuart, J. Darren, Thomas, Dean N., Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tiahshun, Youngman, Mark A.

Volltext

Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase von Elkins, Patricia A, Watts, Joseph M, Zalacain, Magdalena, van Thiel, Adam, Vitazka, Patrik R, Redlak, Maria, Andraos-Selim, Cecile, Rastinejad, Fraydoon, Holmes, Walter M

Volltext

Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK von Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F

Volltext

Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity von Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

Volltext

2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity von Lin, Hong, Yamashita, Dennis S., Zeng, Jin, Xie, Ren, Wang, Wenyong, Nidarmarthy, Sirishkumar, Luengo, Juan I., Rhodes, Nelson, Knick, Victoria B., Choudhry, Anthony E., Lai, Zhihong, Minthorn, Elisabeth A., Strum, Susan L., Wood, Edgar R., Elkins, Patricia A., Concha, Nestor O., Heerding, Dirk A.

Volltext

Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor von Kossiakoff, Anthony A, Elkins, Patricia A, Christinger, Hans W, Sandowski, Yael, Sakal, Edna, Gertler, Arieh, de Vos, Abraham M

Volltext

Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) von Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn, Carson, Jeff D., Elkins, Patricia A., Diamond, Melody, Gardiner, Christine M., Garver, Eric, Luo, Lusong, Raha, Kaushik, Sung, Chiu-Mei, Tummino, Peter J., Auger, Kurt R., Dhanak, Dashyant

Volltext

Insights into catalysis by a knotted TrmD tRNA methyltransferase von Elkins, Patricia A, Watts, Joseph M, Zalacain, Magdalena, van Thiel, Adam, Vitazka, Patrik R, Redlak, Maria, Andraos-Selim, Cecile, Rastinejad, Fraydoon, Holmes, Walter M

Volltext

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin von Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant

Volltext

Crystallization and characterization of colicin E1 channel-forming polypeptides von Elkins, Patricia A., Song, Ho Yeong, Cramer, William A., Stauffacher, Cynthia V.

Volltext

Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor von Christinger, Hans W., Elkins, Patricia A., Sandowski, Yael, Sakal, Edna, Gertler, Arieh, Kossiakoff, Anthony A., De Vos, Abraham M.

Volltext

In-feed supplementation of trans-cinnamaldehyde reduces layer-chicken egg-borne transmission of Salmonella enterica serovar enteritidis von Upadhyaya, Indu, Upadhyay, Abhinav, Kollanoor-Johny, Anup, Mooyottu, Shankumar, Baskaran, Sangeetha A, Yin, Hsin-Bai, Schreiber, David T, Khan, Mazhar I, Darre, Michael J, Curtis, Patricia A, Venkitanarayanan, Kumar

Volltext

Antimicrobial Resistance Laboratory Network's multisite evaluation of the ThermoFisher Sensititre GN7F broth microdilution panel for antimicrobial susceptibility testing von Bhatnagar, Amelia S, Machado, María-José, Patterson, Logan, Anderson, Karen, Abelman, Rebecca L, Bateman, Allen, Biggs, Angela, Bumpus-White, Porscha, Craft, Bradley, Howard, Mondraya, LaVoie, Stephen P, Lonsway, David, Sabour, Sarah, Schneider, Annah, Snippes-Vagnone, Paula, Tran, Michael, Torpey, David, Valley, Ann, Elkins, Christopher A, Karlsson, Maria, Brown, Allison C

Volltext

Immunization with the Haemophilus ducreyi Hemoglobin Receptor HgbA with Adjuvant Monophosphoryl Lipid A Protects Swine from a Homologous but Not a Heterologous Challenge von Fusco, William G, Afonina, Galyna, Nepluev, Igor, Cholon, Deborah M, Choudhary, Neelima, Routh, Patricia A, Almond, Glenn W, Orndorff, Paul E, Staats, Herman, Hobbs, Marcia M, Leduc, Isabelle, Elkins, Christopher

Volltext

Experimental Infection of Chimpanzees with Hepatitis C Virus of Genotype 5a: Genetic Analysis of the Virus and Generation of a Standardized Challenge Pool von Bukh, Jens, Apgar, Carl L., Engle, Ronald, Govindarajan, Sugantha, Hegerich, Patricia A., Tellier, Raymond, Wong, Doris C., Elkins, Randy, Kew, Michael C.

Volltext