The development of imatinib as a therapeutic agent for chronic myeloid leukemia von Deininger, Michael, Buchdunger, Elisabeth, Druker, Brian J.

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug von Capdeville, Renaud, Buchdunger, Elisabeth, Zimmermann, Juerg, Matter, Alex

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Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib von Day, Elizabeth, Waters, Beatrice, Spiegel, Katrin, Alnadaf, Tanja, Manley, Paul W., Buchdunger, Elisabeth, Walker, Christoph, Jarai, Gabor

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Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia von Druker, Brian J, Talpaz, Moshe, Resta, Debra J, Peng, Bin, Buchdunger, Elisabeth, Ford, John M, Lydon, Nicholas B, Kantarjian, Hagop, Capdeville, Renaud, Ohno-Jones, Sayuri, Sawyers, Charles L

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Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro von HOUGHTON, Peter J, GERMAIN, Glen S, HARWOOD, Franklin C, SCHUETZ, John D, STEWART, Clinton F, BUCHDUNGER, Elisabeth, TRAXLER, Peter

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The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy von WARSHAMANA-GREENE, G. Sakuntala, LITZ, Julie, BUCHDUNGER, Elisabeth, GARCIA-ECHEVERRIA, Carlos, HOFMANN, Francesco, KRYSTAL, Geoffrey W

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The Selective Tyrosine Kinase Inhibitor STI571 Inhibits Small Cell Lung Cancer Growth von KRYSTAL, G. W, HONSAWEK, S, LITZ, J, BUCHDUNGER, E

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Tyrosine kinase inhibitors: From rational design to clinical trials von Traxler, Peter, Bold, Guido, Buchdunger, Elisabeth, Caravatti, Giorgio, Furet, Pascal, Manley, Paul, O'Reilly, Terence, Wood, Jeanette, Zimmermann, Juerg

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells von Druker, Brian J., Tamura, Shu, Buchdunger, Elisabeth, Ohno, Sayuri, Segal, Gerald M., Fanning, Shane, Zimmermann, Jürg, Lydon, Nicholas B.

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Analysis of the Structural Basis of Specificity of Inhibition of the Abl Kinase by STI571 von Corbin, Amie S, Buchdunger, Elisabeth, Pascal, Furet, Druker, Brian J

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STI571 Enhances the Therapeutic Index of Epothilone B by a Tumor-selective Increase of Drug Uptake von PIETRAS, Kristian, STUMM, Michael, HUBERT, Martine, BUCHDUNGER, Elisabeth, RUBIN, Kristofer, HELDIN, Carl-Henrik, MCSHEEHY, Paul, WARTMANN, Markus, ÖSTMAN, Arne

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Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors:  4-(Phenylamino)pyrazolo[3,4-d]pyrimidines von Traxler, Peter, Bold, Guido, Frei, Joerg, Lang, Marc, Lydon, Nicholas, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Mueller, Marcel, Furet, Pascal

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New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis von Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W, Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert, Ferrari, Stefano, Furet, Pascal, Hofmann, Francesco, Martiny-Baron, Georg, Mestan, Jürgen, Rösel, Johannes, Sills, Matthew, Stover, David, Acemoglu, Figan, Boss, Eugen, Emmenegger, René, Lässer, Laurent, Masso, Elvira, Roth, Rosemarie, Schlachter, Christian, Vetterli, Werner, Wyss, Dominique, Wood, Jeanette M

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Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives von Zimmermann, Jürg, Buchdunger, Elisabeth, Mett, Helmut, Meyer, Thomas, Lydon, Nicholas B.

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The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I an... von Warshamana-Greene, G Sakuntala, Litz, Julie, Buchdunger, Elisabeth, Hofmann, Francesco, García-Echeverría, Carlos, Krystal, Geoffrey W

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Optimization for the Blockade of Epidermal Growth Factor Receptor Signaling for Therapy of Human Pancreatic Carcinoma von SOLORZANO, Carmen C, BAKER, Cheryl H, TSAN, Rachel, TRAXLER, Peter, COHEN, Pamela, BUCHDUNGER, Elisabeth, KILLION, Jerry J, FIDLER, Isaiah J

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Oral imatinib mesylate (STI571/Gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholes... von LEPPÄNEN, Olli, RUTANEN, Juha, BERGQVIST, David, ALITALO, Kari, HELDIN, Carl-Henrik, ÖSTMAN, Arne, YLÄ-HERTTUALA, Seppo, HILTUNEN, Mikko O, RISSANEN, Tuomas T, TURUNEN, Mikko P, SJÖBLOM, Tobias, BRÜGGEN, Josef, BÄCKSTRÖM, Gudrun, CARLSSON, Marianne, BUCHDUNGER, Elisabeth

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Pharmacology of imatinib (STI571) von Buchdunger, Elisabeth, O'Reilley, Terence, Wood, Jeanette

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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing von Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H

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Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia von Hu, Yiguo, Liu, Yuhua, Pelletier, Shawn, Buchdunger, Elisabeth, Warmuth, Markus, Fabbro, Doriano, Hallek, Michael, Van Etten, Richard A, Li, Shaoguang

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