Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors von Tsimberidou, Apostolia M, Beer, Philip A, Cartwright, Carrie A, Haymaker, Cara, Vo, Henry H, Kiany, Simin, Cecil, Alexander R L, Dow, James, Haque, Kemal, Silva, Franck A, Coe, Lucy, Berryman, Helen, Bone, Elisabeth A, Nogueras-Gonzalez, Graciela M, Vining, David, McElwaine-Johnn, Hilary, Wistuba, Ignacio I

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Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs von Needham, Lindsey A, Davidson, Alan H, Bawden, Lindsay J, Belfield, Andrew, Bone, Elisabeth A, Brotherton, Deborah H, Bryant, Sam, Charlton, Michael H, Clark, Vanessa L, Davies, Stephen J, Donald, Alastair, Day, Francesca A, Krige, David, Legris, Valérie, McDermott, Joanne, McGovern, Yvonne, Owen, Jo, Patel, Sanjay R, Pintat, Stéphane, Testar, Richard J, Wells, Graham M A, Moffat, David, Drummond, Alan H

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CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells von Krige, David, Needham, Lindsey A, Bawden, Lindsay J, Flores, Nicolas, Farmer, Hannah, Miles, Lauren E C, Stone, Erica, Callaghan, Juliana, Chandler, Stephen, Clark, Vanessa L, Kirwin-Jones, Patricia, Legris, Valérie, Owen, Jo, Patel, Thakor, Wood, Steve, Box, Gary, Laber, David, Odedra, Rajesh, Wright, Annette, Wood, L Michael, Eccles, Suzanne A, Bone, Elisabeth A, Ayscough, Andrew, Drummond, Alan H

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Phase I/II Clinical Study of Tosedostat, an Inhibitor of Aminopeptidases, in Patients With Acute Myeloid Leukemia and Myelodysplasia von Bob Löwenberg, Gareth Morgan, Gert J. Ossenkoppele, Alan K. Burnett, Pierre Zachée, Ulrich Dührsen, Daan Dierickx, Carsten Müller-Tidow, Pieter Sonneveld, Utz Krug, Elisabeth Bone, Nicolas Flores, Alison F. Richardson, Leon Hooftman, Chris Jenkins, Sonja Zweegman, Faith Davies

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Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice von Sledge, George W., Qulali, Mona, Goulet, Robert, Bone, Elisabeth A., Fife, Rose

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Preclinical and Clinical Studies of MMP Inhibitors in Cancer von DRUMMOND, ALAN H., BECKETT, PAUL, BROWN, PETER D., BONE, ELISABETH A., DAVIDSON, ALAN H., GALLOWAY, W. ALAN, GEARING, ANDY J.H., HUXLEY, PHIL, LABER, DAVID, MCCOURT, MATTHEW, WHITTAKER, MARK, WOOD, L. MICHAEL, WRIGHT, ANNETTE

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Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase... von Moffat, David, Patel, Sanjay, Day, Francesca, Belfield, Andrew, Donald, Alastair, Rowlands, Martin, Wibawa, Judata, Brotherton, Deborah, Stimson, Lindsay, Clark, Vanessa, Owen, Jo, Bawden, Lindsay, Box, Gary, Bone, Elisabeth, Mortenson, Paul, Hardcastle, Anthea, van Meurs, Sandra, Eccles, Suzanne, Raynaud, Florence, Aherne, Wynne

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Matrix metalloproteinases degrade myelin basic protein von Chandler, Stephen, Coates, Rachael, Gearing, Andrew, Lury, Jon, Wells, Graham, Bone, Elisabeth

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A vasopressin-like peptide in the mammalian sympathetic nervous system von Hanley, Michael R, Benton, Hilary P, Lightman, Stafford L, Todd, Kathryn, Bone, Elisabeth A, Fretten, Pamela, Palmer, Susan, Kirk, Christopher J, Michell, Robert H

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The synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase von Bone, Elisabeth A, Davidson, Alan H, Lewis, Christopher N, Todd, Richard S

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The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice von LOW, J. A, JOHNSON, M. D, BONE, E. A, DICKSON, R. B

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Compounds comprising tricyclic heterocyclic compounds von Silva, Franck Alexandre, Shuttleworth, Stephen Joseph, Cecil, Alexander Richard Liam, Bone, Elisabeth Ann

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DETECTION OF HISTONE MODIFICATION IN CELL-FREE NUCLEOSOMES von Drummond, Alan Hastings, Needham, Lindsey Ann, BAWDEN, Lindsay Jane, Bone, Elisabeth Ann

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Detection of histone modification in cell-free nucleosomes von Drummond, Alan Hastings, Bawden, Lindsay Jane, Needham, Lindsey Ann, Bone, Elisabeth Ann

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Inhibition of Matrix Metalloproteinases: An examination of the S1′ pocket von Miller, Andrew, Askew, Marion, Beckett, R.Paul, Bellamy, Claire L., Bone, Elisabeth A., Coates, Rachael E., Davidson, Alan H., Drummond, Alan H., Huxley, Philip, Martin, Fionna M., Saroglou, Lydia, Thompson, Alison J., van Dijk, Sonja E., Whittaker, Mark

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Thyroglobulin gene activation by thyrotropin and cAMP in hormonally depleted FRTL-5 thyroid cells von Bone, Elisabeth, Kohn, Leonard D., Chomczynski, Piotr

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Characterization of cholecystokinin receptors in toad retina von Bone, Elisabeth A., Rosenzweig, Steven A.

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The design and biological evaluation of a series of 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase inhibitors related to dihydromevinolin von Bone, Elisabeth A., Cunningham, Emer M., Davidson, Alan H., Galloway, W.Alan, Lewis, Christopher N., Morrice, Elizabeth M., Reeve, Maxwell M., Todd, Richard S., White, Ingrid M.

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Strontium ions induce production of thromboxane B 2 and secretion of 5-hydroxytryptamine in washed human platelets von Best, Leonard C., Bone, Elisabeth A., Graham, R., Russell, G.

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Lanthanum stimulates the accumulation of cyclic AMP and inhibits secretion and thromboxane B 2 formation in human platelets von Best, Leonard C., Bone, Elisabeth A., Jones, Peter B.B., Graham, R., Russell, G.

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